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The map label for this gene is cysO [H]

Identifier: 18978230

GI number: 18978230

Start: 1715594

End: 1716448

Strand: Direct

Name: cysO [H]

Synonym: PF1858

Alternate gene names: 18978230

Gene position: 1715594-1716448 (Clockwise)

Preceding gene: 18978229

Following gene: 18978234

Centisome position: 89.9

GC content: 39.42

Gene sequence:

>855_bases
ATGTTTTTTGCCAAGCTTGAGTTCTTTAATCCATTCAGTAGAAGCATCAAAGACAGGCCAGTCTACAACATGATAATGAA
AGCAATTGAAAGCGGAGAAATCGATGGAACAGATACTTTATATGAGGCAACATCTGGGAACGTTGGAATTGCTCTTGCGG
CATTGTCTGCAGTACTTGGACTTAAATTCAGAGCTTATGTCCCAAAACCCACTCCAAAAATAACTGAAATTCTAATCAAA
ATGTTTGGAGCAGAAGTAATCAGGACAAAATTCGAGACTATTGATCCAGAGTTCATAAATTTTGTAAAAGAAGAGGCCAA
GAAAGACAAAGCAGTGAATTTAAATCAGTTTGAGAACGATGCAAATTTCGAAGCCCACTACTATGGAACTGCCAAAGAAC
TTGATGAACAACTCAAAAGCATAAAAAAGAAGCCTGAAGTAATAATAGCTGGAGTGGGAACCTCTGGACATATAGCGGCC
CTTTCAAAATATTTCAAAGAAAAGTATGGGACTAAGATCATAGGAGTTGTACCTGCAGAGGGAGAAAAAATTCCAGGGAT
AAAGAGAATAGAAACGAAACCAAAATGGTTCTTCCAGGTAAAAGTTGACAAAGTCGTTGAGATCACAACAAGGGAAGCTG
TTGAGGGGGCCTTACGAGTAGCTCGAACAGATGGCTTAATAATAGGGCTGAGCTCAGGAGCTGTAGTTAAAGCTTATGAA
AAAATAAATCCCAAGGGAACTACAGTATTGATCTTTCCCGATGACGGGTTTAAGTATGTCGAGATCTTTCAAGCTTTTCT
ACAAGAAGCTCAAGATACGACCTCCTCTCAAACTGCTCGACACCAATCTCCCTAA

Upstream 100 bases:

>100_bases
CCTTATATTGGTGATCAAAAGATGAACGTATTTTCAAGTACCTTAGAGCTATTCGAAAAGTACAAACCAACTCCACTAGT
GAAGCTAGGAATAGGGAGGG

Downstream 100 bases:

>100_bases
GGATTGCCTCTAGCTTTTCCACTGCCTGCGGGATTTCTTCCTCATTTTTTACAAGAGTTTCAATCTCAACAAATTTACCT
AACCCTTCAACATCGTCTAA

Product: cysteine synthase

Products: NA

Alternate protein names: Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MFFAKLEFFNPFSRSIKDRPVYNMIMKAIESGEIDGTDTLYEATSGNVGIALAALSAVLGLKFRAYVPKPTPKITEILIK
MFGAEVIRTKFETIDPEFINFVKEEAKKDKAVNLNQFENDANFEAHYYGTAKELDEQLKSIKKKPEVIIAGVGTSGHIAA
LSKYFKEKYGTKIIGVVPAEGEKIPGIKRIETKPKWFFQVKVDKVVEITTREAVEGALRVARTDGLIIGLSSGAVVKAYE
KINPKGTTVLIFPDDGFKYVEIFQAFLQEAQDTTSSQTARHQSP

Sequences:

>Translated_284_residues
MFFAKLEFFNPFSRSIKDRPVYNMIMKAIESGEIDGTDTLYEATSGNVGIALAALSAVLGLKFRAYVPKPTPKITEILIK
MFGAEVIRTKFETIDPEFINFVKEEAKKDKAVNLNQFENDANFEAHYYGTAKELDEQLKSIKKKPEVIIAGVGTSGHIAA
LSKYFKEKYGTKIIGVVPAEGEKIPGIKRIETKPKWFFQVKVDKVVEITTREAVEGALRVARTDGLIIGLSSGAVVKAYE
KINPKGTTVLIFPDDGFKYVEIFQAFLQEAQDTTSSQTARHQSP
>Mature_284_residues
MFFAKLEFFNPFSRSIKDRPVYNMIMKAIESGEIDGTDTLYEATSGNVGIALAALSAVLGLKFRAYVPKPTPKITEILIK
MFGAEVIRTKFETIDPEFINFVKEEAKKDKAVNLNQFENDANFEAHYYGTAKELDEQLKSIKKKPEVIIAGVGTSGHIAA
LSKYFKEKYGTKIIGVVPAEGEKIPGIKRIETKPKWFFQVKVDKVVEITTREAVEGALRVARTDGLIIGLSSGAVVKAYE
KINPKGTTVLIFPDDGFKYVEIFQAFLQEAQDTTSSQTARHQSP

Specific function: Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=287, Percent_Identity=31.7073170731707, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI295821200, Length=287, Percent_Identity=31.7073170731707, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4557415, Length=287, Percent_Identity=31.7073170731707, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI2367138, Length=264, Percent_Identity=33.7121212121212, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788754, Length=284, Percent_Identity=33.4507042253521, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562970, Length=295, Percent_Identity=32.2033898305085, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32566674, Length=251, Percent_Identity=33.0677290836653, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17535051, Length=248, Percent_Identity=32.258064516129, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115535073, Length=280, Percent_Identity=30.3571428571429, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561720, Length=249, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25147552, Length=265, Percent_Identity=27.5471698113208, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534315, Length=285, Percent_Identity=27.3684210526316, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=291, Percent_Identity=32.3024054982818, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321449, Length=316, Percent_Identity=29.1139240506329, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643623, Length=182, Percent_Identity=35.1648351648352, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129101, Length=182, Percent_Identity=35.1648351648352, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.22; =2.5.1.47; =2.5.1.65 [H]

Molecular weight: Translated: 31585; Mature: 31585

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFAKLEFFNPFSRSIKDRPVYNMIMKAIESGEIDGTDTLYEATSGNVGIALAALSAVLG
CCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHC
LKFRAYVPKPTPKITEILIKMFGAEVIRTKFETIDPEFINFVKEEAKKDKAVNLNQFEND
CHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCC
ANFEAHYYGTAKELDEQLKSIKKKPEVIIAGVGTSGHIAALSKYFKEKYGTKIIGVVPAE
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCC
GEKIPGIKRIETKPKWFFQVKVDKVVEITTREAVEGALRVARTDGLIIGLSSGAVVKAYE
CCCCCCCCEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHH
KINPKGTTVLIFPDDGFKYVEIFQAFLQEAQDTTSSQTARHQSP
HCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MFFAKLEFFNPFSRSIKDRPVYNMIMKAIESGEIDGTDTLYEATSGNVGIALAALSAVLG
CCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHC
LKFRAYVPKPTPKITEILIKMFGAEVIRTKFETIDPEFINFVKEEAKKDKAVNLNQFEND
CHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCC
ANFEAHYYGTAKELDEQLKSIKKKPEVIIAGVGTSGHIAALSKYFKEKYGTKIIGVVPAE
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCC
GEKIPGIKRIETKPKWFFQVKVDKVVEITTREAVEGALRVARTDGLIIGLSSGAVVKAYE
CCCCCCCCEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHH
KINPKGTTVLIFPDDGFKYVEIFQAFLQEAQDTTSSQTARHQSP
HCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966; 12644499 [H]