Click here to switch to the map view.

The map label for this gene is srp54 [H]

Identifier: 18978103

GI number: 18978103

Start: 1608359

End: 1609690

Strand: Direct

Name: srp54 [H]

Synonym: PF1731

Alternate gene names: 18978103

Gene position: 1608359-1609690 (Clockwise)

Preceding gene: 18978102

Following gene: 18978104

Centisome position: 84.28

GC content: 39.71

Gene sequence:

>1332_bases
ATGGTTCTAGATAACCTAGGGAAAGCACTTGCCAACACTCTAAAGAAGATAGCCAGAGCCAGCAGTGTGGATGAAGCTTT
AATCAAAGAGTTAGTTAGGGATATCCAGAGAGCTCTAATTCAAGCTGACGTAAACGTTAGACTAGTTCTTCAACTTACAA
GAGAAATACAGAGAAGAGCACTGGAAGAGAAGCCTCCTGCAGGAATATCTAAGAAAGAACACATTATAAAAATAGTCTAT
GAAGAGTTAACAAAATTCCTCGGAACAGAAGCAAAGCCAATAGAAATCAAGGAGAAACCAACAATTTTGTTAATGGTTGG
AATTCAGGGAAGTGGAAAAACTACAACGGTTGCAAAACTTGCGAGATACTTCCAAAAAAGAGGATATAAGGTCGGAGTTG
TATGTTCAGATACCTGGAGACCTGGGGCTTATCACCAGCTTAGGCAACTTCTAGATCGTTACCACATAGAAGTGTTTGGA
AATCCTCAAGAAAAAGATGCCATAAAGTTAGCAAAAGAAGGAGTTGATTACTTCAAATCTAAAGGAGTAGACATAATAAT
AGTGGATACCGCGGGAAGGCACAAAGAAGACAAGGCGTTAATTGAAGAGATGAAGCAAATAAGCAACGTAATACATCCTC
ATGAGGTTATACTTGTAATTGATGGAACAATAGGACAACAAGCATACAACCAGGCCTTAGCCTTTAAAGAAGCAACACCG
ATTGGCTCCATAATAGTCACAAAGCTCGATGGATCTGCCAAGGGAGGAGGAGCCCTTTCTGCAGTTGCCGCAACAGGGGC
TCCAATAAAATTCATAGGTACGGGAGAAAAGATAGATGATATCGAGCCCTTTGACCCACCGAGATTTGTTTCAAGACTCT
TGGGACTTGGAGATATTCAAGGATTGCTGGAAAAATTTAAGGAGTTAGAGAAAGAAGTTGAAATAAAAGAGGAAGACATT
GAAAGATTCTTAAGGGGTAAATTTACACTTAAGGACATGTATGCTCAGCTTGAAGCGATGAGAAAAATGGGGCCCCTAAA
ACAAATACTGAGAATGATTCCCGGGCTGGGATATTCCCTTCCCGATGACGTGATCTCAATCGGAGAAGAGAGGCTAAAGA
AATTCAAAGTAATAATGGATTCAATGACAGAGGAAGAACTGCTAAATCCCGAGATAATAAACTATTCCAGGATCAAGAGA
ATTGCAAGAGGATCAGGAACATCTACAAAGGATGTAAAAGAACTTTTAGATCAATATAGGCAGATGAAAAAGTTATTTAA
GAGCATGAACAAGAGACAATTGAGCAGACTTGCCAGGAGGTTTGGTATGTAA

Upstream 100 bases:

>100_bases
AAGATGTTTGATGAAATTAAGATAATTGACGCAACTAAAAGTGTAGAAGAGGTCCATAGGGAAATAATAAGTTCGATAAA
AGAAATCTGGGGGAAAAACT

Downstream 100 bases:

>100_bases
TGGAAGCATTCATTCTAGTAATAACATATCCTGGAAAGGAAAAAGAGGTATATGAGGCACTAAAGGCTAGGCCAGAAGTG
AAGGAGATATACAGAGTTTA

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54 [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVLDNLGKALANTLKKIARASSVDEALIKELVRDIQRALIQADVNVRLVLQLTREIQRRALEEKPPAGISKKEHIIKIVY
EELTKFLGTEAKPIEIKEKPTILLMVGIQGSGKTTTVAKLARYFQKRGYKVGVVCSDTWRPGAYHQLRQLLDRYHIEVFG
NPQEKDAIKLAKEGVDYFKSKGVDIIIVDTAGRHKEDKALIEEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATP
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGTGEKIDDIEPFDPPRFVSRLLGLGDIQGLLEKFKELEKEVEIKEEDI
ERFLRGKFTLKDMYAQLEAMRKMGPLKQILRMIPGLGYSLPDDVISIGEERLKKFKVIMDSMTEEELLNPEIINYSRIKR
IARGSGTSTKDVKELLDQYRQMKKLFKSMNKRQLSRLARRFGM

Sequences:

>Translated_443_residues
MVLDNLGKALANTLKKIARASSVDEALIKELVRDIQRALIQADVNVRLVLQLTREIQRRALEEKPPAGISKKEHIIKIVY
EELTKFLGTEAKPIEIKEKPTILLMVGIQGSGKTTTVAKLARYFQKRGYKVGVVCSDTWRPGAYHQLRQLLDRYHIEVFG
NPQEKDAIKLAKEGVDYFKSKGVDIIIVDTAGRHKEDKALIEEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATP
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGTGEKIDDIEPFDPPRFVSRLLGLGDIQGLLEKFKELEKEVEIKEEDI
ERFLRGKFTLKDMYAQLEAMRKMGPLKQILRMIPGLGYSLPDDVISIGEERLKKFKVIMDSMTEEELLNPEIINYSRIKR
IARGSGTSTKDVKELLDQYRQMKKLFKSMNKRQLSRLARRFGM
>Mature_443_residues
MVLDNLGKALANTLKKIARASSVDEALIKELVRDIQRALIQADVNVRLVLQLTREIQRRALEEKPPAGISKKEHIIKIVY
EELTKFLGTEAKPIEIKEKPTILLMVGIQGSGKTTTVAKLARYFQKRGYKVGVVCSDTWRPGAYHQLRQLLDRYHIEVFG
NPQEKDAIKLAKEGVDYFKSKGVDIIIVDTAGRHKEDKALIEEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATP
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGTGEKIDDIEPFDPPRFVSRLLGLGDIQGLLEKFKELEKEVEIKEEDI
ERFLRGKFTLKDMYAQLEAMRKMGPLKQILRMIPGLGYSLPDDVISIGEERLKKFKVIMDSMTEEELLNPEIINYSRIKR
IARGSGTSTKDVKELLDQYRQMKKLFKSMNKRQLSRLARRFGM

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=440, Percent_Identity=45, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI226371618, Length=387, Percent_Identity=47.0284237726098, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=57.5342465753425, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI295424842, Length=314, Percent_Identity=25.4777070063694, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=314, Percent_Identity=25.4777070063694, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788963, Length=429, Percent_Identity=35.6643356643357, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1789874, Length=268, Percent_Identity=35.8208955223881, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=41.0958904109589, Blast_Score=357, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=30.2325581395349, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=449, Percent_Identity=42.3162583518931, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6320498, Length=323, Percent_Identity=26.0061919504644, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=43.1818181818182, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=27.7272727272727, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49880; Mature: 49880

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLDNLGKALANTLKKIARASSVDEALIKELVRDIQRALIQADVNVRLVLQLTREIQRRA
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LEEKPPAGISKKEHIIKIVYEELTKFLGTEAKPIEIKEKPTILLMVGIQGSGKTTTVAKL
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCHHHHHHH
ARYFQKRGYKVGVVCSDTWRPGAYHQLRQLLDRYHIEVFGNPQEKDAIKLAKEGVDYFKS
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHH
KGVDIIIVDTAGRHKEDKALIEEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATP
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGTGEKIDDIEPFDPPRFVSRLLGLGDIQ
CCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCHHHH
GLLEKFKELEKEVEIKEEDIERFLRGKFTLKDMYAQLEAMRKMGPLKQILRMIPGLGYSL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
PDDVISIGEERLKKFKVIMDSMTEEELLNPEIINYSRIKRIARGSGTSTKDVKELLDQYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
QMKKLFKSMNKRQLSRLARRFGM
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLDNLGKALANTLKKIARASSVDEALIKELVRDIQRALIQADVNVRLVLQLTREIQRRA
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LEEKPPAGISKKEHIIKIVYEELTKFLGTEAKPIEIKEKPTILLMVGIQGSGKTTTVAKL
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCHHHHHHH
ARYFQKRGYKVGVVCSDTWRPGAYHQLRQLLDRYHIEVFGNPQEKDAIKLAKEGVDYFKS
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHH
KGVDIIIVDTAGRHKEDKALIEEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATP
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGTGEKIDDIEPFDPPRFVSRLLGLGDIQ
CCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCHHHH
GLLEKFKELEKEVEIKEEDIERFLRGKFTLKDMYAQLEAMRKMGPLKQILRMIPGLGYSL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
PDDVISIGEERLKKFKVIMDSMTEEELLNPEIINYSRIKRIARGSGTSTKDVKELLDQYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
QMKKLFKSMNKRQLSRLARRFGM
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]