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The map label for this gene is tmk

Identifier: 18978102

GI number: 18978102

Start: 1607740

End: 1608372

Strand: Direct

Name: tmk

Synonym: PF1730

Alternate gene names: 18978102

Gene position: 1607740-1608372 (Clockwise)

Preceding gene: 33359571

Following gene: 18978103

Centisome position: 84.25

GC content: 39.34

Gene sequence:

>633_bases
ATGAAGAGAGGGCTCTTCATAGTCCTCGAAGGGATAGATGGCTCTGGCAAAACAACACAGGCAAGACTACTAGCAAGATG
GTTTGAGGACAATGGATTCAAAGTCGTACTCACAAAAGAACCTACCGACACAGAGTTTGGAAAGATCATTAGAAAGCTAG
TGTTAGAAGGAAGCATAATAGATGGGGGTAGAATAAGCCTAGAGGCTGAAGCTTTGCTCTTTGCAGCAGACAGGGCCGAA
CATGTGAAAAAGATAATAGAACCAGCCCTTAGAGAGGGGAAAGTAGTAATTTCAGATAGATACTTTTATTCCTCTCTAGC
ATACCAATGGGCGAGGGGATTAAACCTGGAGTGGTTAATAGAGATAAACAAATTTGCCCCGCATCCAGATATAGCAATTC
TCCTTGACATACCTCCAAGGGAAGGCATAAAAAGGATCAAAAAAAGAAGTTCACAGACGGAATTCGACAAGTTATTTAAG
TTGCAAGAGAAAGTAAGAGAGAATTATATAAAACTTGCCAAGATGTTTGATGAAATTAAGATAATTGACGCAACTAAAAG
TGTAGAAGAGGTCCATAGGGAAATAATAAGTTCGATAAAAGAAATCTGGGGGAAAAACTATGGTTCTAGATAA

Upstream 100 bases:

>100_bases
TGGAATAGCTGAAGTCTATAAAGACAATGAAGTGAAGGAGTTCGATAGCTTATGGAAGCTACTTGATCACTTGGCTAAAT
TTTAATGCTTGGTGAAAATA

Downstream 100 bases:

>100_bases
CCTAGGGAAAGCACTTGCCAACACTCTAAAGAAGATAGCCAGAGCCAGCAGTGTGGATGAAGCTTTAATCAAAGAGTTAG
TTAGGGATATCCAGAGAGCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKRGLFIVLEGIDGSGKTTQARLLARWFEDNGFKVVLTKEPTDTEFGKIIRKLVLEGSIIDGGRISLEAEALLFAADRAE
HVKKIIEPALREGKVVISDRYFYSSLAYQWARGLNLEWLIEINKFAPHPDIAILLDIPPREGIKRIKKRSSQTEFDKLFK
LQEKVRENYIKLAKMFDEIKIIDATKSVEEVHREIISSIKEIWGKNYGSR

Sequences:

>Translated_210_residues
MKRGLFIVLEGIDGSGKTTQARLLARWFEDNGFKVVLTKEPTDTEFGKIIRKLVLEGSIIDGGRISLEAEALLFAADRAE
HVKKIIEPALREGKVVISDRYFYSSLAYQWARGLNLEWLIEINKFAPHPDIAILLDIPPREGIKRIKKRSSQTEFDKLFK
LQEKVRENYIKLAKMFDEIKIIDATKSVEEVHREIISSIKEIWGKNYGSR
>Mature_210_residues
MKRGLFIVLEGIDGSGKTTQARLLARWFEDNGFKVVLTKEPTDTEFGKIIRKLVLEGSIIDGGRISLEAEALLFAADRAE
HVKKIIEPALREGKVVISDRYFYSSLAYQWARGLNLEWLIEINKFAPHPDIAILLDIPPREGIKRIKKRSSQTEFDKLFK
LQEKVRENYIKLAKMFDEIKIIDATKSVEEVHREIISSIKEIWGKNYGSR

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=197, Percent_Identity=30.4568527918782, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17535647, Length=156, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322517, Length=201, Percent_Identity=33.8308457711443, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573735, Length=209, Percent_Identity=31.1004784688995, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PYRFU (Q8U071)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579459.1
- ProteinModelPortal:   Q8U071
- SMR:   Q8U071
- EnsemblBacteria:   EBPYRT00000004139
- GeneID:   1469607
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1730
- NMPDR:   fig|186497.1.peg.1778
- GeneTree:   EBGT00050000022466
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK00698
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24160; Mature: 24160

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGLFIVLEGIDGSGKTTQARLLARWFEDNGFKVVLTKEPTDTEFGKIIRKLVLEGSII
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCC
DGGRISLEAEALLFAADRAEHVKKIIEPALREGKVVISDRYFYSSLAYQWARGLNLEWLI
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEEEE
EINKFAPHPDIAILLDIPPREGIKRIKKRSSQTEFDKLFKLQEKVRENYIKLAKMFDEIK
EECCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIDATKSVEEVHREIISSIKEIWGKNYGSR
EEHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRGLFIVLEGIDGSGKTTQARLLARWFEDNGFKVVLTKEPTDTEFGKIIRKLVLEGSII
CCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCC
DGGRISLEAEALLFAADRAEHVKKIIEPALREGKVVISDRYFYSSLAYQWARGLNLEWLI
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEEEE
EINKFAPHPDIAILLDIPPREGIKRIKKRSSQTEFDKLFKLQEKVRENYIKLAKMFDEIK
EECCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIDATKSVEEVHREIISSIKEIWGKNYGSR
EEHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA