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The map label for this gene is hisZ [H]

Identifier: 18978029

GI number: 18978029

Start: 1543003

End: 1543884

Strand: Direct

Name: hisZ [H]

Synonym: PF1657

Alternate gene names: 18978029

Gene position: 1543003-1543884 (Clockwise)

Preceding gene: 18978027

Following gene: 18978030

Centisome position: 80.86

GC content: 38.21

Gene sequence:

>882_bases
ATGTGGGCTAAGAGAAGCATGGAGGAGTATATTAAAATTGCTGAAATTGCAAACAAGCTTCGCTCGATTTTTCAACTCTG
GGGATATAAAGAAGTGGTATTTCCAATTATCGAGGAATACTCACCTGAAATTAGAAAAGGAACAAAATTTGCCTATAATA
ACTTGTTCTATCTAATCTCCCCAGACGTCACATCAAGAATAATAAAACAGTTCAAAGACGGAAATGCAAAGGTATTCTAC
ATAGCAGAGGTCCTAAATGGTGATGTTAAGGGAGAATGGCAGGCTGGAATAGAGTTCATTGGAGGAAAAGGTCTGGGAAT
GTATCTTGAAGCTCTTTCGATAGCAATAACATCCCTAGAAAGTCTTGGAATTACAGAATTCTACATCGACATTGGAAGCA
TTGAGGTTTGGAAAGAACTAAGCGGAGAATACTGGCCCAAAATAAAAGAAGCCCTAATAAAGCGAAACTTTGAGATAATA
GAAAATATTCCAATTCCCAAGGACAAAAAAGACAAGATGTGGGAGTTATTTAATTTTAGGGGAAGAAGAAGTGGAATAGA
AAAATTAGACACTATAGTTGATTCCATAGAGGATCCAAGGGTGTTTATAGACCTAGGAACTGTTCGTCCACTTCCCTACT
ATACCGACATAATATTCGAAATATACTCTCCCCAGGTAGGAAAACCAATAGGGGGAGGAGGAGAATATGAGGTTAGAGGA
AAGCAGGCGATTGGCTTCGTTTTCTACTTAAATAGGTTGCTAAGTCTTTACAGACCGAAAGATAGGGCAAGAAAAGTTAT
TTCTGAAATAGATCCTAAGAAAGCATATTCCACAGCTAGAGAAATGGTGAGACTAGGAATTCCAGTGGAGGTGAGGTTAT
GA

Upstream 100 bases:

>100_bases
AAGTCTAAGTGGTTTTGACCATGCTAGCCTTTGCATACCTACACCTTCATCATCATTGATCTCTATTCTCTCTTCACTTG
GTTAGTTGGAGGTGTTTTCT

Downstream 100 bases:

>100_bases
GGTTTGTTTTACCAAAGGGAAGGCTTTACCAAGATTCGATAAAAGTACTAGAACTCGCTGGAATAAAAGTTCCAAAGAGA
GACGAAAGAGCTCTAATCTG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MWAKRSMEEYIKIAEIANKLRSIFQLWGYKEVVFPIIEEYSPEIRKGTKFAYNNLFYLISPDVTSRIIKQFKDGNAKVFY
IAEVLNGDVKGEWQAGIEFIGGKGLGMYLEALSIAITSLESLGITEFYIDIGSIEVWKELSGEYWPKIKEALIKRNFEII
ENIPIPKDKKDKMWELFNFRGRRSGIEKLDTIVDSIEDPRVFIDLGTVRPLPYYTDIIFEIYSPQVGKPIGGGGEYEVRG
KQAIGFVFYLNRLLSLYRPKDRARKVISEIDPKKAYSTAREMVRLGIPVEVRL

Sequences:

>Translated_293_residues
MWAKRSMEEYIKIAEIANKLRSIFQLWGYKEVVFPIIEEYSPEIRKGTKFAYNNLFYLISPDVTSRIIKQFKDGNAKVFY
IAEVLNGDVKGEWQAGIEFIGGKGLGMYLEALSIAITSLESLGITEFYIDIGSIEVWKELSGEYWPKIKEALIKRNFEII
ENIPIPKDKKDKMWELFNFRGRRSGIEKLDTIVDSIEDPRVFIDLGTVRPLPYYTDIIFEIYSPQVGKPIGGGGEYEVRG
KQAIGFVFYLNRLLSLYRPKDRARKVISEIDPKKAYSTAREMVRLGIPVEVRL
>Mature_293_residues
MWAKRSMEEYIKIAEIANKLRSIFQLWGYKEVVFPIIEEYSPEIRKGTKFAYNNLFYLISPDVTSRIIKQFKDGNAKVFY
IAEVLNGDVKGEWQAGIEFIGGKGLGMYLEALSIAITSLESLGITEFYIDIGSIEVWKELSGEYWPKIKEALIKRNFEII
ENIPIPKDKKDKMWELFNFRGRRSGIEKLDTIVDSIEDPRVFIDLGTVRPLPYYTDIIFEIYSPQVGKPIGGGGEYEVRG
KQAIGFVFYLNRLLSLYRPKDRARKVISEIDPKKAYSTAREMVRLGIPVEVRL

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004517
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 33821; Mature: 33821

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWAKRSMEEYIKIAEIANKLRSIFQLWGYKEVVFPIIEEYSPEIRKGTKFAYNNLFYLIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCEEECCEEEEEC
PDVTSRIIKQFKDGNAKVFYIAEVLNGDVKGEWQAGIEFIGGKGLGMYLEALSIAITSLE
CCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHHCHHEECCCCHHHHHHHHHHHHHHHH
SLGITEFYIDIGSIEVWKELSGEYWPKIKEALIKRNFEIIENIPIPKDKKDKMWELFNFR
HCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCC
GRRSGIEKLDTIVDSIEDPRVFIDLGTVRPLPYYTDIIFEIYSPQVGKPIGGGGEYEVRG
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECC
KQAIGFVFYLNRLLSLYRPKDRARKVISEIDPKKAYSTAREMVRLGIPVEVRL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure
MWAKRSMEEYIKIAEIANKLRSIFQLWGYKEVVFPIIEEYSPEIRKGTKFAYNNLFYLIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCEEECCEEEEEC
PDVTSRIIKQFKDGNAKVFYIAEVLNGDVKGEWQAGIEFIGGKGLGMYLEALSIAITSLE
CCHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHHCHHEECCCCHHHHHHHHHHHHHHHH
SLGITEFYIDIGSIEVWKELSGEYWPKIKEALIKRNFEIIENIPIPKDKKDKMWELFNFR
HCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCC
GRRSGIEKLDTIVDSIEDPRVFIDLGTVRPLPYYTDIIFEIYSPQVGKPIGGGGEYEVRG
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECC
KQAIGFVFYLNRLLSLYRPKDRARKVISEIDPKKAYSTAREMVRLGIPVEVRL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA