Click here to switch to the map view.

The map label for this gene is top6A [H]

Identifier: 18977950

GI number: 18977950

Start: 1473914

End: 1475062

Strand: Reverse

Name: top6A [H]

Synonym: PF1578

Alternate gene names: 18977950

Gene position: 1475062-1473914 (Counterclockwise)

Preceding gene: 18977951

Following gene: 18977949

Centisome position: 77.3

GC content: 41.78

Gene sequence:

>1149_bases
TTGAAGTTGAAGAGGGGGAAGCCTAAAGAAAAATTCTCATATGATCCTCAAAAGGTATTAAAAAAGCTTGAGGATCTTGC
TTATAAGATACTAGAGGAGGTTAAAGCAGGCAAGAATCCATACTTCGATGTTCCAACAAGGGGGTTAAGTAATGTCTACT
TTGATGAAGAGGCCAGATTGATTAAGCTAGGAGATAAGCTATCAAGGAGATACTTCCTCAACGTTGCCCATGCAAGGAAG
TTTATGCAGACGTTGATCTTGATGGCCTATGTAAAAAGGTTAGTTTCAGAAGGGAAACATGCGAGCTTAAGAGAAGCCTA
TTATGCGAACAAGCACACTATTCCGGGTACTCATGAAAATACATTTGAAGATCAGAGTGAAAGCGATCCAATTATAGAGG
ATCTCGAGAGAATGCTTGGAGTACTCAGAGAGGAGATGCACATCACTGCAGATAGACGTGGATATGTTTATGGAGATATT
GTAATTAAGGATGGGGAAGATGAATTTAACGCATCAAAGCTTGGAATGGGTGGTTGGGCAGTTCCTGGGACTGTAGAGCA
CATTCAGTTCCCAGAGATAAACGTTGATTATGTTCTAGTTGTTGAGACTGCAGCAATGGCTGATAGATTGATAGAAGAAA
AGTATCCAAAGAGGGAAAGAGCACTGATAATTGCGACCCAGGGACAGGCTTCAAGGGGTGTAAGAAGGCTAATTCACAGG
CTTCACTATGAAGAGGGGTTGCCGATAATTGTCTTCACGGATGGAGATCCCTACGGTTGGTACATATATTCAACAATAAA
GCAGGGATCCATAAACTTAGCTTATCTCAGCGAAAAGCTAGCAACTCCAGATGCAAAATTCGTTGGAATGACTATGGATG
ACATAAAAGAATACGGCCTTGAGCATGTTACAGAGAAGCTCAAAGGAATACCTCCAGACAAGAAAGGAGGACCAACTGGA
GACTACAAGAGGTTAATTGAGGAACTCAACTATCCATGGTTCCAAAACAAGGAGTGGCAGAGACAATTAAAGCTTGCTCT
TAAGTGGGGAGTGAGAATAGAGCAACAGGCATTGGCAAACAAATCTCTAGAGTTTGTCGCAAAGGAGTATCTGCCTGAGA
AAATTAGAGAAGGTAAACTGCTACCGTGA

Upstream 100 bases:

>100_bases
CTTCACATTTTAACTGGCGAGCCTGAGGAGAAAATCAAGGAATATTTCCTTAGGTTGATAGAAAGCAAAATCACCGTTGC
ACAAGAGGGGGTGAGCGAAG

Downstream 100 bases:

>100_bases
TGGAGTATGCCAACGACTGAAGAGCTTATAGCAAGAATAAACAAAATACTCGATGACATAGCGATAGATACCCCTGGGTT
ATTTGAAGATTTTGATGTTC

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARK
FMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDI
VIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHR
LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTG
DYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP

Sequences:

>Translated_382_residues
MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARK
FMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDI
VIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHR
LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTG
DYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP
>Mature_382_residues
MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARK
FMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDI
VIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHR
LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTG
DYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=367, Percent_Identity=24.2506811989101, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI38201680, Length=304, Percent_Identity=25.6578947368421, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45552753, Length=364, Percent_Identity=23.6263736263736, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 44073; Mature: 44073

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARL
CCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHH
IKLGDKLSRRYFLNVAHARKFMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCC
TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDIVIKDGEDEFNASKLGMGGWA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHCCCCCCC
VPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHR
CCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGL
HHHHCCCEEEEEECCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCCEECCCHHHHHHHHH
EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
KSLEFVAKEYLPEKIREGKLLP
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARL
CCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHH
IKLGDKLSRRYFLNVAHARKFMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCC
TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDIVIKDGEDEFNASKLGMGGWA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHCCCCCCC
VPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHR
CCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGL
HHHHCCCEEEEEECCCCCCEEEEEEECCCCEEHHHHHHHHCCCCCCEECCCHHHHHHHHH
EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
KSLEFVAKEYLPEKIREGKLLP
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]