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The map label for this gene is 18977941

Identifier: 18977941

GI number: 18977941

Start: 1465890

End: 1466684

Strand: Reverse

Name: 18977941

Synonym: PF1569

Alternate gene names: NA

Gene position: 1466684-1465890 (Counterclockwise)

Preceding gene: 18977942

Following gene: 18977940

Centisome position: 76.86

GC content: 39.62

Gene sequence:

>795_bases
ATGAGGAGAATTTTTGTTCAAAATAGAGAATTAGTAGTACCTGGAACGCTATTGGCCCAAGGGCCTTATAAAAATGGGAG
AGGAACTTTCAAAGAAGGTTCAAGGATATACTCAACGGTAATAGGACTTGTAGACATAAAGGGAAACACAATCAGAGTTA
TCCCCTTAGAGGGGCCCTATATACCTGAAGTTGGGGATAATGTACTTGGGAAAATTGTCGACGTTAAATTCTCAAGCTGG
ACCGTTGACATAGGTTCTCCCTATTCTGCAACTTTGAAAATTCAGGACTATACAGATGAAAAAATAGACCTCCTGAGGAC
AGATCTAAGGAAATTCTTTGATATAGGGGATATTATTTACGCCAAGGTAAAGGGAATTAATGAGGTCAATAACATAGAGC
TAACGACAAAGGGCATGCCATTTAATGGGGGGCCTCTTAGGGGAGGACAAATAATCAAGATTACATCATCAAAGGTTCCA
AGAGTAATAGGAAAGGGAGGATCAATGATTAATATGATCAAAAAGCTAACTCAGAGCAGAATTATAGTTGGCCAAAACGG
CTGGATTTGGATAAGTAGTAAAAATCCTGAGCTAGAGAAGCTCGCCATAGAGGCAATACTCAAGATAGAGCGAGAAAGCC
ACACAAGAGGGTTGACTGATAGAATAAAAAATATGCTTCTTTCAAAATTGCAAGAATTAAAGGAACGGGGAGTTATAGAA
GAAATTCCCTCCCTAGAGGAGGAAACACAGGAAGAAACGGTGATGGAAAATGATGTTGAAGCCAGAGGGCCTTAA

Upstream 100 bases:

>100_bases
TAATTGAAATCCCAGGTGGAGTTGAGGAGGAGTTTTACGAGAAGCTAAATGCCCTTACAAAGAGCAGTGCTCAAACTAAA
CTAATAGAGAGGAAGGGGTT

Downstream 100 bases:

>100_bases
ACTAATTGATGAGAATGGTAGAAGGCTTGATGGTAGAAAAAAGTATGAGCTCAGGCCTATTAAAATGAAAGTCGGTGTCT
TAAAGAATGCAAATGGGTCT

Product: exosome complex RNA-binding protein Rrp4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRRIFVQNRELVVPGTLLAQGPYKNGRGTFKEGSRIYSTVIGLVDIKGNTIRVIPLEGPYIPEVGDNVLGKIVDVKFSSW
TVDIGSPYSATLKIQDYTDEKIDLLRTDLRKFFDIGDIIYAKVKGINEVNNIELTTKGMPFNGGPLRGGQIIKITSSKVP
RVIGKGGSMINMIKKLTQSRIIVGQNGWIWISSKNPELEKLAIEAILKIERESHTRGLTDRIKNMLLSKLQELKERGVIE
EIPSLEEETQEETVMENDVEARGP

Sequences:

>Translated_264_residues
MRRIFVQNRELVVPGTLLAQGPYKNGRGTFKEGSRIYSTVIGLVDIKGNTIRVIPLEGPYIPEVGDNVLGKIVDVKFSSW
TVDIGSPYSATLKIQDYTDEKIDLLRTDLRKFFDIGDIIYAKVKGINEVNNIELTTKGMPFNGGPLRGGQIIKITSSKVP
RVIGKGGSMINMIKKLTQSRIIVGQNGWIWISSKNPELEKLAIEAILKIERESHTRGLTDRIKNMLLSKLQELKERGVIE
EIPSLEEETQEETVMENDVEARGP
>Mature_264_residues
MRRIFVQNRELVVPGTLLAQGPYKNGRGTFKEGSRIYSTVIGLVDIKGNTIRVIPLEGPYIPEVGDNVLGKIVDVKFSSW
TVDIGSPYSATLKIQDYTDEKIDLLRTDLRKFFDIGDIIYAKVKGINEVNNIELTTKGMPFNGGPLRGGQIIKITSSKVP
RVIGKGGSMINMIKKLTQSRIIVGQNGWIWISSKNPELEKLAIEAILKIERESHTRGLTDRIKNMLLSKLQELKERGVIE
EIPSLEEETQEETVMENDVEARGP

Specific function: Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential)

COG id: COG1097

COG function: function code J; RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI19923403, Length=228, Percent_Identity=27.1929824561404, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321860, Length=191, Percent_Identity=29.3193717277487, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24762324, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECR1_PYRFU (Q8U0L8)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579298.1
- ProteinModelPortal:   Q8U0L8
- SMR:   Q8U0L8
- EnsemblBacteria:   EBPYRT00000004495
- GeneID:   1469445
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1569
- NMPDR:   fig|186497.1.peg.1616
- GeneTree:   EBGT00050000022799
- HOGENOM:   HBG392276
- OMA:   GQNGRIW
- ProtClustDB:   PRK04163
- GO:   GO:0005737
- HAMAP:   MF_00623
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR004044
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00322
- SMART:   SM00316

Pfam domain/function: PF07650 KH_2; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 29535; Mature: 29535

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50084 KH_TYPE_1; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIFVQNRELVVPGTLLAQGPYKNGRGTFKEGSRIYSTVIGLVDIKGNTIRVIPLEGPY
CCEEEECCCEEEECCCEEECCCCCCCCCCCCCCHHHHHHHEEEEEECCCEEEEEECCCCC
IPEVGDNVLGKIVDVKFSSWTVDIGSPYSATLKIQDYTDEKIDLLRTDLRKFFDIGDIIY
CCCCCHHHHHHEEEEEECEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AKVKGINEVNNIELTTKGMPFNGGPLRGGQIIKITSSKVPRVIGKGGSMINMIKKLTQSR
HHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHHCE
IIVGQNGWIWISSKNPELEKLAIEAILKIERESHTRGLTDRIKNMLLSKLQELKERGVIE
EEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHH
EIPSLEEETQEETVMENDVEARGP
HCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRRIFVQNRELVVPGTLLAQGPYKNGRGTFKEGSRIYSTVIGLVDIKGNTIRVIPLEGPY
CCEEEECCCEEEECCCEEECCCCCCCCCCCCCCHHHHHHHEEEEEECCCEEEEEECCCCC
IPEVGDNVLGKIVDVKFSSWTVDIGSPYSATLKIQDYTDEKIDLLRTDLRKFFDIGDIIY
CCCCCHHHHHHEEEEEECEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AKVKGINEVNNIELTTKGMPFNGGPLRGGQIIKITSSKVPRVIGKGGSMINMIKKLTQSR
HHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHHCE
IIVGQNGWIWISSKNPELEKLAIEAILKIERESHTRGLTDRIKNMLLSKLQELKERGVIE
EEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHH
EIPSLEEETQEETVMENDVEARGP
HCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA