Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 18977766

GI number: 18977766

Start: 1308192

End: 1309112

Strand: Reverse

Name: serA [H]

Synonym: PF1394

Alternate gene names: 18977766

Gene position: 1309112-1308192 (Counterclockwise)

Preceding gene: 18977767

Following gene: 18977764

Centisome position: 68.6

GC content: 40.17

Gene sequence:

>921_bases
GTGAAGGTGCTTGTAGCTGCCCCTCTTCATGAAAAGGCTCTAAATATACTAAAAGATGCTGGTTTTGAAGTTATTTACGA
GGAGTATCCGGAGGAAAATAGGCTTTTAGAATTAGTTAGAGATGTTGAAGCTATTATAGTTAGAAGTAAGCCAAAGATTA
CAAGAAAGGTAATAGAAAATGCTCCAAAATTAAAGGTAATTGCAAGAGCTGGAGTTGGATTGGATAACATAGATGTTGAA
GCTGCTAAAGAGAAAGGCATTGAAGTTGTTAATGCTCCAGCAGCCAGTTCTAGAAGTGTTGCAGAGTTGGCTGTTGGGTT
GATGTTTGCAGTTGCTAGGAAGATAGCTTATGCTGATAGAAAGATGAGGGAAGGAAAGTGGGCGAAGAAGGAGTGTATGG
GTATAGAACTTGAAGGAAAAACCCTTGGAATAATTGGATTTGGAAGAATTGGCTATCAAGTTGCGAAGATTGCAAGAGCT
TTAGGCATGAAATTGTTACTTTATGACCCCTACCCTAACGAAGAGAGAGCTAAAGAAGTCGGTGGAAAGTTTGTGGATCT
AGAAACACTGCTAAAGGAGAGCGATATAGTCACAATTCATGTTCCATTAATTCCGGAAACATATCACCTCATTAACGAAG
AGAGACTTAGGCTTATGAAGAGAACAGCTATTTTAATAAACACTTCGAGAGGGGCTGTAGTCGATACACAGGCCCTAATT
AAAGCTCTTGAAGAGGGATGGATTGCGGGTGCAGGGTTAGATGTATTTGAAGAAGAGCCTCTTCCAGAAAACCATCCACT
AACGAAATTTGACAATGTTGTTCTAACACCTCACATAGGAGCCTCAACTTACGAAGCCCAGGAGAGAGCGGGAGTAGAAG
TAGCGGAAAAAATTGTAGAAATACTAAAGAAGAGCTCTTAA

Upstream 100 bases:

>100_bases
TTTGGAACCAAATTATCACAAAAATTGGAGATATTGCCGATAGGGCTGAAGATGCTTCAGACCATATAATGCTTATGGCC
GTTAAAAGGAGGTGATAATG

Downstream 100 bases:

>100_bases
TCTCCTATAGATCCTTTCTAATCTCTTTTTTGGAACTCTTGCTTTTTTGGCAAGCTCCTCTATCTTCCAATTAAGGAAGT
CTTCAGGCTTCGTTATACCT

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKVLVAAPLHEKALNILKDAGFEVIYEEYPEENRLLELVRDVEAIIVRSKPKITRKVIENAPKLKVIARAGVGLDNIDVE
AAKEKGIEVVNAPAASSRSVAELAVGLMFAVARKIAYADRKMREGKWAKKECMGIELEGKTLGIIGFGRIGYQVAKIARA
LGMKLLLYDPYPNEERAKEVGGKFVDLETLLKESDIVTIHVPLIPETYHLINEERLRLMKRTAILINTSRGAVVDTQALI
KALEEGWIAGAGLDVFEEEPLPENHPLTKFDNVVLTPHIGASTYEAQERAGVEVAEKIVEILKKSS

Sequences:

>Translated_306_residues
MKVLVAAPLHEKALNILKDAGFEVIYEEYPEENRLLELVRDVEAIIVRSKPKITRKVIENAPKLKVIARAGVGLDNIDVE
AAKEKGIEVVNAPAASSRSVAELAVGLMFAVARKIAYADRKMREGKWAKKECMGIELEGKTLGIIGFGRIGYQVAKIARA
LGMKLLLYDPYPNEERAKEVGGKFVDLETLLKESDIVTIHVPLIPETYHLINEERLRLMKRTAILINTSRGAVVDTQALI
KALEEGWIAGAGLDVFEEEPLPENHPLTKFDNVVLTPHIGASTYEAQERAGVEVAEKIVEILKKSS
>Mature_306_residues
MKVLVAAPLHEKALNILKDAGFEVIYEEYPEENRLLELVRDVEAIIVRSKPKITRKVIENAPKLKVIARAGVGLDNIDVE
AAKEKGIEVVNAPAASSRSVAELAVGLMFAVARKIAYADRKMREGKWAKKECMGIELEGKTLGIIGFGRIGYQVAKIARA
LGMKLLLYDPYPNEERAKEVGGKFVDLETLLKESDIVTIHVPLIPETYHLINEERLRLMKRTAILINTSRGAVVDTQALI
KALEEGWIAGAGLDVFEEEPLPENHPLTKFDNVVLTPHIGASTYEAQERAGVEVAEKIVEILKKSS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=305, Percent_Identity=43.2786885245902, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=37.0229007633588, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=37.0229007633588, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=35.546875, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=35.3383458646617, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=35.3383458646617, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=35.3383458646617, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1789279, Length=317, Percent_Identity=40.0630914826498, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=39.0041493775934, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082289, Length=263, Percent_Identity=36.1216730038023, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788660, Length=260, Percent_Identity=33.8461538461538, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87081824, Length=167, Percent_Identity=31.1377245508982, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=41.6666666666667, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25147481, Length=237, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=38.3116883116883, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320925, Length=308, Percent_Identity=37.6623376623377, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=228, Percent_Identity=37.719298245614, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324964, Length=305, Percent_Identity=31.8032786885246, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324980, Length=183, Percent_Identity=34.4262295081967, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=28.0575539568345, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=284, Percent_Identity=25, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=40.7894736842105, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28574286, Length=294, Percent_Identity=37.0748299319728, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=36.9230769230769, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=36.9230769230769, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=36.9230769230769, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=36.9230769230769, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=29.6774193548387, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=35.3697749196142, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=36.9230769230769, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45552429, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28574284, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24585514, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28574282, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI45551003, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33823; Mature: 33823

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVAAPLHEKALNILKDAGFEVIYEEYPEENRLLELVRDVEAIIVRSKPKITRKVIEN
CEEEEECCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
APKLKVIARAGVGLDNIDVEAAKEKGIEVVNAPAASSRSVAELAVGLMFAVARKIAYADR
CCCEEEEEECCCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KMREGKWAKKECMGIELEGKTLGIIGFGRIGYQVAKIARALGMKLLLYDPYPNEERAKEV
HHHCCCCHHHHHCCEEECCCEEEEEEECHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GGKFVDLETLLKESDIVTIHVPLIPETYHLINEERLRLMKRTAILINTSRGAVVDTQALI
CCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEECHHHHH
KALEEGWIAGAGLDVFEEEPLPENHPLTKFDNVVLTPHIGASTYEAQERAGVEVAEKIVE
HHHHHCCEECCCCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHCCHHHHHHHHH
ILKKSS
HHHCCC
>Mature Secondary Structure
MKVLVAAPLHEKALNILKDAGFEVIYEEYPEENRLLELVRDVEAIIVRSKPKITRKVIEN
CEEEEECCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
APKLKVIARAGVGLDNIDVEAAKEKGIEVVNAPAASSRSVAELAVGLMFAVARKIAYADR
CCCEEEEEECCCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KMREGKWAKKECMGIELEGKTLGIIGFGRIGYQVAKIARALGMKLLLYDPYPNEERAKEV
HHHCCCCHHHHHCCEEECCCEEEEEEECHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GGKFVDLETLLKESDIVTIHVPLIPETYHLINEERLRLMKRTAILINTSRGAVVDTQALI
CCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEECHHHHH
KALEEGWIAGAGLDVFEEEPLPENHPLTKFDNVVLTPHIGASTYEAQERAGVEVAEKIVE
HHHHHCCEECCCCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHCCHHHHHHHHH
ILKKSS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]