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The map label for this gene is yxlA [H]

Identifier: 18977708

GI number: 18977708

Start: 1256605

End: 1257858

Strand: Reverse

Name: yxlA [H]

Synonym: PF1336

Alternate gene names: 18977708

Gene position: 1257858-1256605 (Counterclockwise)

Preceding gene: 18977709

Following gene: 18977707

Centisome position: 65.92

GC content: 44.82

Gene sequence:

>1254_bases
ATGTATGATATTAAACCTGTTAAGGAGAGAATATTCGACTTCTGGAGCAACTTTTCAATATGGTTTGGCGCTGATTTTGG
AATAGCAGTAATATGGGCCGGAGCACTGTTAACCCCATATCTCTCGCTTAAAGAGGCCCTCCTTGTTATAATCCTTGGCC
ACCTCCTGGGAAATGCAGTAATGAGCTTAATAGCTGTAGAGGGGCAAAGAACAGGACTTCCAACCATGGTTCTCTCGAGG
GCTCCCTTAGGTGGTAAAGGTTCAGTTCTACCGTCTATCTTGAACTATCTCCAGCTCATAGGATGGACAGCGATAATGTT
GATAGTGGGTGGAAAGGCCTTAGATGTAATATTCCCAGGGACTTACAGGTTATGGATATTGATACTGGGTATATTGGTTA
CACTGTGGACCCTTTCTGGACCTGAGAGATGGAGATGGCTTGAAAAGCTTTCAGTAGTCCTCCTGGGAATATTGAGCGTT
TGGCTTCTCTATGTGATATTCTCCAAATACTCATTCTCAGAACTTTGGAACAGGCCAGGAGAGGGAGGGTTGCCATTGTT
AATAGCCCTCGACCTTGTAATAGCGATGCCCCTAAGCTGGGCTCCAACGATAGCAGATTATTCAAGAATGGCGAAGAGTG
AGAGAGATGCAGCCTGGGGAACTTACCTCGGCCACTTAGCCGGTTCAGCCTTCTGTTACTTCCTGGGAGCCTTGAGCAAC
ATAGCTGTTAAGCAACCAGATCCAATAAGCATAATAGCCACTTACGGCCTTGGAATTCCAGCTATGCTAATGGTCCTTGT
CTCAACATTGAACACAACCTTCATGGACATATATTCTGCAGCAATAACGTGGAAGAATATAAACCCGAGAGCAAACGCAA
AAACCCAGGTAATATTGGTTGGTGTCCTGGGAACTCTGCTAGCCTTAGTGTTCCCAGTAGATAAGTACGAGTCCTTCCTT
CTGCTAATAGGAGGAGCATTCGTCCCATTAGCTGCAATAATGATAACGGACTTCTTCCTTGTAAATAAGGGAAGGTATGA
AGTTGAGTCACTCCTCGAAGATAGGAAAGTCAAGGTAAGAGGAATAATCAGTTGGCTAATTGGGTTCCTCCTCTACCTGG
GACTCACAATGGAGGCCTTAATTGGAGTGAAAGTACCAGTCTTAAGCGATTTAGGCAACTCAATAGGAGCAAGCATTCCA
GTCTTTTTGATCTCTGCCATAATATATTACCTCCTTGAGAGGTGGGGAGAATGA

Upstream 100 bases:

>100_bases
AAGCACGGAGAATTTGAGAAAGAGAGGGCAAGAGAAGTGTTTAAAGAGGTTTCAAAGTTCGAGTTGATATTCTGGGATAT
AGCCTATGGAGGTGAAGGGA

Downstream 100 bases:

>100_bases
TTAGCGTCGGGGAGGCCTTAGCTAAGGTTAGGGAAAGAAAGCCCCTAGTCCACAACATTACAAACTTCGTAGTTATGAAC
ACCACAGCGAACGCTCTCCT

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MYDIKPVKERIFDFWSNFSIWFGADFGIAVIWAGALLTPYLSLKEALLVIILGHLLGNAVMSLIAVEGQRTGLPTMVLSR
APLGGKGSVLPSILNYLQLIGWTAIMLIVGGKALDVIFPGTYRLWILILGILVTLWTLSGPERWRWLEKLSVVLLGILSV
WLLYVIFSKYSFSELWNRPGEGGLPLLIALDLVIAMPLSWAPTIADYSRMAKSERDAAWGTYLGHLAGSAFCYFLGALSN
IAVKQPDPISIIATYGLGIPAMLMVLVSTLNTTFMDIYSAAITWKNINPRANAKTQVILVGVLGTLLALVFPVDKYESFL
LLIGGAFVPLAAIMITDFFLVNKGRYEVESLLEDRKVKVRGIISWLIGFLLYLGLTMEALIGVKVPVLSDLGNSIGASIP
VFLISAIIYYLLERWGE

Sequences:

>Translated_417_residues
MYDIKPVKERIFDFWSNFSIWFGADFGIAVIWAGALLTPYLSLKEALLVIILGHLLGNAVMSLIAVEGQRTGLPTMVLSR
APLGGKGSVLPSILNYLQLIGWTAIMLIVGGKALDVIFPGTYRLWILILGILVTLWTLSGPERWRWLEKLSVVLLGILSV
WLLYVIFSKYSFSELWNRPGEGGLPLLIALDLVIAMPLSWAPTIADYSRMAKSERDAAWGTYLGHLAGSAFCYFLGALSN
IAVKQPDPISIIATYGLGIPAMLMVLVSTLNTTFMDIYSAAITWKNINPRANAKTQVILVGVLGTLLALVFPVDKYESFL
LLIGGAFVPLAAIMITDFFLVNKGRYEVESLLEDRKVKVRGIISWLIGFLLYLGLTMEALIGVKVPVLSDLGNSIGASIP
VFLISAIIYYLLERWGE
>Mature_417_residues
MYDIKPVKERIFDFWSNFSIWFGADFGIAVIWAGALLTPYLSLKEALLVIILGHLLGNAVMSLIAVEGQRTGLPTMVLSR
APLGGKGSVLPSILNYLQLIGWTAIMLIVGGKALDVIFPGTYRLWILILGILVTLWTLSGPERWRWLEKLSVVLLGILSV
WLLYVIFSKYSFSELWNRPGEGGLPLLIALDLVIAMPLSWAPTIADYSRMAKSERDAAWGTYLGHLAGSAFCYFLGALSN
IAVKQPDPISIIATYGLGIPAMLMVLVSTLNTTFMDIYSAAITWKNINPRANAKTQVILVGVLGTLLALVFPVDKYESFL
LLIGGAFVPLAAIMITDFFLVNKGRYEVESLLEDRKVKVRGIISWLIGFLLYLGLTMEALIGVKVPVLSDLGNSIGASIP
VFLISAIIYYLLERWGE

Specific function: Required For Cytosine Transport Into The Cell. [C]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=349, Percent_Identity=27.2206303724928, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 45864; Mature: 45864

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDIKPVKERIFDFWSNFSIWFGADFGIAVIWAGALLTPYLSLKEALLVIILGHLLGNAV
CCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSLIAVEGQRTGLPTMVLSRAPLGGKGSVLPSILNYLQLIGWTAIMLIVGGKALDVIFPG
HHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
TYRLWILILGILVTLWTLSGPERWRWLEKLSVVLLGILSVWLLYVIFSKYSFSELWNRPG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
EGGLPLLIALDLVIAMPLSWAPTIADYSRMAKSERDAAWGTYLGHLAGSAFCYFLGALSN
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IAVKQPDPISIIATYGLGIPAMLMVLVSTLNTTFMDIYSAAITWKNINPRANAKTQVILV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHEEHH
GVLGTLLALVFPVDKYESFLLLIGGAFVPLAAIMITDFFLVNKGRYEVESLLEDRKVKVR
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
GIISWLIGFLLYLGLTMEALIGVKVPVLSDLGNSIGASIPVFLISAIIYYLLERWGE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYDIKPVKERIFDFWSNFSIWFGADFGIAVIWAGALLTPYLSLKEALLVIILGHLLGNAV
CCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSLIAVEGQRTGLPTMVLSRAPLGGKGSVLPSILNYLQLIGWTAIMLIVGGKALDVIFPG
HHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
TYRLWILILGILVTLWTLSGPERWRWLEKLSVVLLGILSVWLLYVIFSKYSFSELWNRPG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
EGGLPLLIALDLVIAMPLSWAPTIADYSRMAKSERDAAWGTYLGHLAGSAFCYFLGALSN
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IAVKQPDPISIIATYGLGIPAMLMVLVSTLNTTFMDIYSAAITWKNINPRANAKTQVILV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHEEHH
GVLGTLLALVFPVDKYESFLLLIGGAFVPLAAIMITDFFLVNKGRYEVESLLEDRKVKVR
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
GIISWLIGFLLYLGLTMEALIGVKVPVLSDLGNSIGASIPVFLISAIIYYLLERWGE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377 [H]