Click here to switch to the map view.

The map label for this gene is coaD

Identifier: 18977456

GI number: 18977456

Start: 1033428

End: 1033910

Strand: Reverse

Name: coaD

Synonym: PF1084

Alternate gene names: 18977456

Gene position: 1033910-1033428 (Counterclockwise)

Preceding gene: 33359537

Following gene: 18977455

Centisome position: 54.18

GC content: 41.61

Gene sequence:

>483_bases
ATGAAAAAGAAGTACAAAAAAGTTGTCGTTGGTGGAACTTTCGATAGGCTTCACCTGGGCCACAAGGCCCTCTTGAGGAA
AGCATTTGAAGTTGGTGAGATAGTCTACATAGGCTTAACATCAGATGAGATGATTAAGGAAAAACAATACTCCGAGAGAA
TTCTCCCCTATGAGAAAAGGCTCCTCGACCTCATCAAGTTCTTGGAGGTGAACAAATACAGGAACTATAGGATAATGAAG
ATTCACAATGCTATTGGATTTACAACTAAAATTAAGAGTTTAGAGGCTATAGTTGTTAGTGAGGAAACTTACAAGGGGGC
TGTTCTCGTGAATAAGGCGAGGGAAGAGTTGGGCTTAAGGCCTTTGGACATAGTTGTCATTCCAATAATAAGGAGTAGAC
TCGGGTGTAAGATAAGCTCTTCCCTCATAAGGGCAGGACTTATAGACCCATTTGGCAACCCAATTAGGAGGGAAGAGAAG
TGA

Upstream 100 bases:

>100_bases
CTCTCTGAATGAGCCAAATATGGCCACACTATTTGGGTAAAAGAAGTACCTCATTTCAACCCCCGAGAAGTTTTTATTTA
ATCAAGATAAAAGGGTAGCG

Downstream 100 bases:

>100_bases
GGGCAGTAGTTGTTGGAGCTGGGCTTGGTGGCCTTCTTGCTGGGGCATTTTTGGCGAGGAATGGACATGAAATCATTGTC
CTAGAGAAGTCAGCCATGAT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKKKYKKVVVGGTFDRLHLGHKALLRKAFEVGEIVYIGLTSDEMIKEKQYSERILPYEKRLLDLIKFLEVNKYRNYRIMK
IHNAIGFTTKIKSLEAIVVSEETYKGAVLVNKAREELGLRPLDIVVIPIIRSRLGCKISSSLIRAGLIDPFGNPIRREEK

Sequences:

>Translated_160_residues
MKKKYKKVVVGGTFDRLHLGHKALLRKAFEVGEIVYIGLTSDEMIKEKQYSERILPYEKRLLDLIKFLEVNKYRNYRIMK
IHNAIGFTTKIKSLEAIVVSEETYKGAVLVNKAREELGLRPLDIVVIPIIRSRLGCKISSSLIRAGLIDPFGNPIRREEK
>Mature_160_residues
MKKKYKKVVVGGTFDRLHLGHKALLRKAFEVGEIVYIGLTSDEMIKEKQYSERILPYEKRLLDLIKFLEVNKYRNYRIMK
IHNAIGFTTKIKSLEAIVVSEETYKGAVLVNKAREELGLRPLDIVVIPIIRSRLGCKISSSLIRAGLIDPFGNPIRREEK

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG1019

COG function: function code R; Predicted nucleotidyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic CoaD family

Homologues:

Organism=Homo sapiens, GI205277394, Length=161, Percent_Identity=32.2981366459627, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI110227605, Length=161, Percent_Identity=32.2981366459627, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI110227603, Length=161, Percent_Identity=32.2981366459627, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI110227601, Length=161, Percent_Identity=32.2981366459627, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25143409, Length=125, Percent_Identity=44, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321716, Length=148, Percent_Identity=35.1351351351351, Blast_Score=86, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24658602, Length=164, Percent_Identity=39.6341463414634, Blast_Score=93, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_PYRFU (Q8U1X0)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578813.1
- ProteinModelPortal:   Q8U1X0
- SMR:   Q8U1X0
- EnsemblBacteria:   EBPYRT00000005731
- GeneID:   1468950
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1084
- NMPDR:   fig|186497.1.peg.1121
- GeneTree:   EBGT00050000023071
- HOGENOM:   HBG593121
- OMA:   ISTTRIR
- ProtClustDB:   PRK00777
- BRENDA:   2.7.7.3
- GO:   GO:0005737
- HAMAP:   MF_00647
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 18428; Mature: 18428

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS01190 RIBOSOMAL_L36E

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKYKKVVVGGTFDRLHLGHKALLRKAFEVGEIVYIGLTSDEMIKEKQYSERILPYEKR
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHH
LLDLIKFLEVNKYRNYRIMKIHNAIGFTTKIKSLEAIVVSEETYKGAVLVNKAREELGLR
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHEEEEEECCCCCCCEEEEHHHHHHCCC
PLDIVVIPIIRSRLGCKISSSLIRAGLIDPFGNPIRREEK
CHHHEEEHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKKYKKVVVGGTFDRLHLGHKALLRKAFEVGEIVYIGLTSDEMIKEKQYSERILPYEKR
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHH
LLDLIKFLEVNKYRNYRIMKIHNAIGFTTKIKSLEAIVVSEETYKGAVLVNKAREELGLR
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHEEEEEECCCCCCCEEEEHHHHHHCCC
PLDIVVIPIIRSRLGCKISSSLIRAGLIDPFGNPIRREEK
CHHHEEEHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA