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The map label for this gene is thrC [H]

Identifier: 18977427

GI number: 18977427

Start: 1009071

End: 1010255

Strand: Direct

Name: thrC [H]

Synonym: PF1055

Alternate gene names: 18977427

Gene position: 1009071-1010255 (Clockwise)

Preceding gene: 18977426

Following gene: 18977428

Centisome position: 52.88

GC content: 41.86

Gene sequence:

>1185_bases
ATGGTGCTGAAATGTGTAGTCTGTGGGAGAGAGTATCCTGAAGACGAAGTTAGGTATAGGTGTGAGTGTGGAGGTCTATT
AGAGGTTGTTATCGATCTAGATAAAGTTGATACTTCCATTTTTAACGGTAAGGAGATAAAGCTGTGGAAATATGAAAGCT
GGCTACCCGTAAAGAAGAGAGTTAGTCTGGAAGAAGGTGGAACTCCCCTATATAGGTTATTAAATCTTGAAAGTGATCTT
GGAGTAAAAGAGCTCTATGCAAAAAACGAGGGTGCGAATCCAACAGGTTCATTTAAAGACCGCGGAATGACGGTTGGAGT
CTCGAAGGCTCTTGAGCTAGGAATGGATAAAGTCATATGTGCATCTACGGGAAATACTTCAGCATCACTTGCTGCTTATG
CTGCAAAAGCAGGAATAAAAGCATATGTCCTAATCCCAAGTGGGAAGATAGCGTTAGGAAAGCTTGCTCAAGCAATAATC
TATGGGGCTAGGGTTGTACCAATCAAGGGGAACTTTGACGATGCTCTAAGAGTAGTCGTGGAGACAAGCAAAGAACTTGG
GATATACATGTTAAATTCAATAAACCCATTCAGGCTCGAAGGACAAAAGACAATAGCGTATGAGATATATGACCAACTTG
GAAAAGTTCCAGACAACGTTATTCTCCCAGTTGGAAATGCAGGAAACATTTCTGCAATATGGAAGGGGTTTAAGGAGATG
TATGAGGCTGGCGTAATAGATGAACTTCCCAGGATGATAGGAATTCAAGCAGAAGGAGCATCCCCATTAGCGAAGGCTTG
GAAAGAGAAAAGAAAATTCCAACCCGAAGAGAGTCCAGAAACCATTGCATCGGCCATAAGAATAGGAAACCCCGCAAATT
GGATAAAGGCATGGAGGGCTGTTGAAGAATCTGGGGGACTATTTGAGAGCGTAAGTGATGAGGAAATACTAAGAGCTCAG
AAACTTCTAGCGTCTAGGGAAGGACTATTTGTTGAACCTGCTTCTGCAGCATCTTTAGCTGGCTTAATTAAGCTCCTTGA
AAGTGGTGAAATAAGCAGGAATGAGAGTTACGTTTTAATCACAACTGGACATGGGCTAAAAGATCCAAATATCGTCATAA
AGAACTTCCAAGTTCCAGAACCTATAGACCCAACTTTAGAAGCTTTTAAGGAGGTGATTGAATGA

Upstream 100 bases:

>100_bases
GGGAGAACCTCAAAGAAATAGGGAAGGCTATGAAGGAGGCGTTTGAAAGTTTTGGAATTGAGGCTGAATACTGGGTGACA
AAGGTTGGTAGGGGTGCAAA

Downstream 100 bases:

>100_bases
AAGCAGCCGTTTTAGGAGCAACTGGACTCGTAGGAAGGACTTTCGTGAAATTACTCAGCGGACACCCATGGTTTAAAGTC
AGTAAGCTTGTAGCATCTGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MVLKCVVCGREYPEDEVRYRCECGGLLEVVIDLDKVDTSIFNGKEIKLWKYESWLPVKKRVSLEEGGTPLYRLLNLESDL
GVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVICASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAII
YGARVVPIKGNFDDALRVVVETSKELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNVILPVGNAGNISAIWKGFKEM
YEAGVIDELPRMIGIQAEGASPLAKAWKEKRKFQPEESPETIASAIRIGNPANWIKAWRAVEESGGLFESVSDEEILRAQ
KLLASREGLFVEPASAASLAGLIKLLESGEISRNESYVLITTGHGLKDPNIVIKNFQVPEPIDPTLEAFKEVIE

Sequences:

>Translated_394_residues
MVLKCVVCGREYPEDEVRYRCECGGLLEVVIDLDKVDTSIFNGKEIKLWKYESWLPVKKRVSLEEGGTPLYRLLNLESDL
GVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVICASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAII
YGARVVPIKGNFDDALRVVVETSKELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNVILPVGNAGNISAIWKGFKEM
YEAGVIDELPRMIGIQAEGASPLAKAWKEKRKFQPEESPETIASAIRIGNPANWIKAWRAVEESGGLFESVSDEEILRAQ
KLLASREGLFVEPASAASLAGLIKLLESGEISRNESYVLITTGHGLKDPNIVIKNFQVPEPIDPTLEAFKEVIE
>Mature_394_residues
MVLKCVVCGREYPEDEVRYRCECGGLLEVVIDLDKVDTSIFNGKEIKLWKYESWLPVKKRVSLEEGGTPLYRLLNLESDL
GVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVICASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAII
YGARVVPIKGNFDDALRVVVETSKELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNVILPVGNAGNISAIWKGFKEM
YEAGVIDELPRMIGIQAEGASPLAKAWKEKRKFQPEESPETIASAIRIGNPANWIKAWRAVEESGGLFESVSDEEILRAQ
KLLASREGLFVEPASAASLAGLIKLLESGEISRNESYVLITTGHGLKDPNIVIKNFQVPEPIDPTLEAFKEVIE

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=274, Percent_Identity=28.8321167883212, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786185, Length=302, Percent_Identity=26.158940397351, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790207, Length=318, Percent_Identity=27.3584905660377, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789505, Length=251, Percent_Identity=29.4820717131474, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 43053; Mature: 43053

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKCVVCGREYPEDEVRYRCECGGLLEVVIDLDKVDTSIFNGKEIKLWKYESWLPVKKR
CEEEEEECCCCCCHHHHEEEECCCCEEEEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHH
VSLEEGGTPLYRLLNLESDLGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVIC
CCCCCCCCHHHHEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEE
ASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAIIYGARVVPIKGNFDDALRVVV
ECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
ETSKELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNVILPVGNAGNISAIWKGFKEM
HCCCCCCEEEECCCCCEEECCCEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
YEAGVIDELPRMIGIQAEGASPLAKAWKEKRKFQPEESPETIASAIRIGNPANWIKAWRA
HHCCCHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
VEESGGLFESVSDEEILRAQKLLASREGLFVEPASAASLAGLIKLLESGEISRNESYVLI
HHHCCCCHHCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCEEEE
TTGHGLKDPNIVIKNFQVPEPIDPTLEAFKEVIE
ECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MVLKCVVCGREYPEDEVRYRCECGGLLEVVIDLDKVDTSIFNGKEIKLWKYESWLPVKKR
CEEEEEECCCCCCHHHHEEEECCCCEEEEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHH
VSLEEGGTPLYRLLNLESDLGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVIC
CCCCCCCCHHHHEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEE
ASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAIIYGARVVPIKGNFDDALRVVV
ECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
ETSKELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNVILPVGNAGNISAIWKGFKEM
HCCCCCCEEEECCCCCEEECCCEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
YEAGVIDELPRMIGIQAEGASPLAKAWKEKRKFQPEESPETIASAIRIGNPANWIKAWRA
HHCCCHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
VEESGGLFESVSDEEILRAQKLLASREGLFVEPASAASLAGLIKLLESGEISRNESYVLI
HHHCCCCHHCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCEEEE
TTGHGLKDPNIVIKNFQVPEPIDPTLEAFKEVIE
ECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]