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The map label for this gene is adk

Identifier: 18977417

GI number: 18977417

Start: 997903

End: 998565

Strand: Direct

Name: adk

Synonym: PF1045

Alternate gene names: 18977417

Gene position: 997903-998565 (Clockwise)

Preceding gene: 18977415

Following gene: 18977418

Centisome position: 52.29

GC content: 40.57

Gene sequence:

>663_bases
GTGAACATTCTAATATTTGGTCCCCCAGGGAGCGGAAAATCAACCCAGGCAAGAAGAATTGTAGAAAGATATGGATTAAC
TTACATTTCCTCTGGAGACTTAATAAGAAAAGAAATTGCAGAAGGAACACCTCTCGGACGAGAAATGCAGGCTTATCTTG
CCAGAGGAGATCTAATTCCTGACACCATAGTGAACACTTTAATAATCTCAAAGCTCAGGAGGGTTAGAAAGGATTTTATA
ATGGATGGCTATCCTAGAACTCCCGAGCAGGTGATAGCACTAGAAAATTATCTCTATGACCATGGGATAAAAATAGATGT
GGCCATAGACATATACGTCTCCCTAGAGGAGAGTATTAGAAGAGTATCTGGAAGAAGGATATGTCCCAAGTGCGGAGCGG
TTTATCATGTCGAATTCAATCCTCCCAAGATACCTGGGAGATGTGATGTATGTGGGGCGGAGCTAGTTCAGAGAGAAGAT
GATAGACCGGAAGTTGTTGAAAAACGATATAGGATTTATATGAAAAATATGGAGCCCATAATCAAGTTTTATCAGAAGCA
GAGGATCTACGTAAAAATAAACGGACATGGAAATATTGACGAAGTATGGGAGAGAATAAGGCCTCTATTAGATTACATCC
GCAATAGGGAGGCGATGATTTGA

Upstream 100 bases:

>100_bases
TATCCACTAGCCCTAACGAATCCAGTCATTAGCTTGGGCATGGCATTCACCAATTAATTTTTGTAGGTTGTAGTATAAAT
CACTAACTGGTGATCCCAAG

Downstream 100 bases:

>100_bases
CTCCGGAAAATCTGATCGATGATGAAGTCCAGCCCGAATGAGCCGAGGTGATAGTATGCTAAGATTTGAAATAAAGGACA
GGGATGCTGCTGGAAGGATT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MNILIFGPPGSGKSTQARRIVERYGLTYISSGDLIRKEIAEGTPLGREMQAYLARGDLIPDTIVNTLIISKLRRVRKDFI
MDGYPRTPEQVIALENYLYDHGIKIDVAIDIYVSLEESIRRVSGRRICPKCGAVYHVEFNPPKIPGRCDVCGAELVQRED
DRPEVVEKRYRIYMKNMEPIIKFYQKQRIYVKINGHGNIDEVWERIRPLLDYIRNREAMI

Sequences:

>Translated_220_residues
MNILIFGPPGSGKSTQARRIVERYGLTYISSGDLIRKEIAEGTPLGREMQAYLARGDLIPDTIVNTLIISKLRRVRKDFI
MDGYPRTPEQVIALENYLYDHGIKIDVAIDIYVSLEESIRRVSGRRICPKCGAVYHVEFNPPKIPGRCDVCGAELVQRED
DRPEVVEKRYRIYMKNMEPIIKFYQKQRIYVKINGHGNIDEVWERIRPLLDYIRNREAMI
>Mature_220_residues
MNILIFGPPGSGKSTQARRIVERYGLTYISSGDLIRKEIAEGTPLGREMQAYLARGDLIPDTIVNTLIISKLRRVRKDFI
MDGYPRTPEQVIALENYLYDHGIKIDVAIDIYVSLEESIRRVSGRRICPKCGAVYHVEFNPPKIPGRCDVCGAELVQRED
DRPEVVEKRYRIYMKNMEPIIKFYQKQRIYVKINGHGNIDEVWERIRPLLDYIRNREAMI

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=211, Percent_Identity=36.4928909952607, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=35.1219512195122, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=35.1219512195122, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI310110345, Length=223, Percent_Identity=34.5291479820628, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI53832003, Length=223, Percent_Identity=34.5291479820628, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI8051579, Length=223, Percent_Identity=34.5291479820628, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI53832001, Length=223, Percent_Identity=34.5291479820628, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=31.6279069767442, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706497, Length=216, Percent_Identity=26.3888888888889, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI22749187, Length=207, Percent_Identity=25.1207729468599, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=36.405529953917, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=33.0188679245283, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17537943, Length=207, Percent_Identity=31.4009661835749, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=218, Percent_Identity=27.9816513761468, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=37.1980676328502, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=36.2244897959184, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=218, Percent_Identity=22.4770642201835, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI22026816, Length=217, Percent_Identity=34.1013824884793, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI17737899, Length=213, Percent_Identity=36.6197183098592, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645822, Length=213, Percent_Identity=36.6197183098592, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24663208, Length=214, Percent_Identity=28.9719626168224, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647141, Length=214, Percent_Identity=28.9719626168224, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PYRFU (Q8U207)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578774.1
- ProteinModelPortal:   Q8U207
- SMR:   Q8U207
- EnsemblBacteria:   EBPYRT00000005056
- GeneID:   1468911
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1045
- NMPDR:   fig|186497.1.peg.1082
- GeneTree:   EBGT00050000023191
- HOGENOM:   HBG630208
- OMA:   MEPIIKF
- ProtClustDB:   PRK00279
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25543; Mature: 25543

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIFGPPGSGKSTQARRIVERYGLTYISSGDLIRKEIAEGTPLGREMQAYLARGDLIP
CEEEEECCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
DTIVNTLIISKLRRVRKDFIMDGYPRTPEQVIALENYLYDHGIKIDVAIDIYVSLEESIR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHH
RVSGRRICPKCGAVYHVEFNPPKIPGRCDVCGAELVQREDDRPEVVEKRYRIYMKNMEPI
HHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IKFYQKQRIYVKINGHGNIDEVWERIRPLLDYIRNREAMI
HHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNILIFGPPGSGKSTQARRIVERYGLTYISSGDLIRKEIAEGTPLGREMQAYLARGDLIP
CEEEEECCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCH
DTIVNTLIISKLRRVRKDFIMDGYPRTPEQVIALENYLYDHGIKIDVAIDIYVSLEESIR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHH
RVSGRRICPKCGAVYHVEFNPPKIPGRCDVCGAELVQREDDRPEVVEKRYRIYMKNMEPI
HHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IKFYQKQRIYVKINGHGNIDEVWERIRPLLDYIRNREAMI
HHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA