Click here to switch to the map view.

The map label for this gene is pmrA [H]

Identifier: 18977353

GI number: 18977353

Start: 937611

End: 938864

Strand: Direct

Name: pmrA [H]

Synonym: PF0981

Alternate gene names: 18977353

Gene position: 937611-938864 (Clockwise)

Preceding gene: 18977352

Following gene: 18977357

Centisome position: 49.13

GC content: 38.52

Gene sequence:

>1254_bases
GTGAACAGAGAAAAGGCAATAGTGATTCAAGGATTGCGAGGGAGAGTGGGAAAAGTTAAGAGGAGGTCAACGGCGAGAAG
AAACATGATATTTCTTGCTATAGCAATGTTCTTTGCTAATATATCTTGGGGAATAGCTTTTCCGTACCTAGGTGTTTATA
TGAGGATTATTGGAGGGAGCGTATTCCTTGTTGGACTTTTGAGCGTGATATTTAACATTACCTCCACAGTGTTTCAATAT
CCTTTTGGATATCTTTCAGATAGAACTGGAAAAAGAAAACCCTTCATAGCCCTGGGAATTTTATCCTCTGGAGGAACTTA
TGCATTAATAGCATTCATATCTAGTCCAATCCTCTTACTAGGATTAAGAGGACTTCAAGGGGCTTTAAGTGCTTCCCTTT
CTCCAGCTCATTCTGCTCTAATTTCTGAACTTGCTACAAGGGTAGGCTCGGCTTTTGGGTTTTTTAACTTTGTTGAAAAC
CTTGGATATATGGTAGGGAACTTTCTTGGAGGCTTTATTGTCCAATATCTTGACATTAAAAGTGCATTCTTCATAGCTTC
AGCTTTTTCTCTACTTTCCATATTATTCCTCCTTCCAATTAGGGAAAGGGTAAGCAATAGAAAAAGCGTTCAGGGTTTGA
TAATAGTGCAAGAAGGAAGAGAGTCAGAAAAAGTTGAGATGAAAAGAATGGCCTTCAAAAGATTAATGAGGGGAAAACTA
GGGCTGTTTTATATTTCGGTATTCTTGGCTATGATAGCATCAGGGGAAGTTTACTCTACAATCTCCGTATATTTTGAAGA
GAAATTTGGGGAAAATTTCGTTGGCATATTTTTTGGTATTGATTCTCTTGCTGCAGCTTTAAGCTCCTTGGTAATTGGTA
GGCTTATTGATAGATGGGGAGCTGAGGTTTTCTATAAGTTGTCTCTAATTGGGTATACTTTTACCTTTCTAGGCTACGCT
TTTGTCAATGATCCGATAACAATGGGAATAGTTTCAGTCTTTTCAGGAATAAAATGGGCCATGTTCATAAGCTCAGTTTC
CACATATGTTGCTAAAAAAGTTCCTTCAAGTGAAAGAGGACAAGGGATGGGGCTGCTAAACACTATGATGAGCTTAGGAT
GGGTTTTGGGTCCTCTCATTGGAGGATATCTTGCTGATATAAGTTTTAGAATAATGCTGTATTCAACGGTAGTTCCATTG
TTGTTAGCCTTTACAATTGTATCAATACCTTATCCGCGGCATCCCTCTGAATGA

Upstream 100 bases:

>100_bases
CCCCCACTCGATTAACTTTTAGTTTTCGATGAACTTATAAGCTTTACTCCTTCTACATCTCACAGCTTAACGATGAGAAG
AAAATCTAAAGGTGGTGAAA

Downstream 100 bases:

>100_bases
GTACCCTGCCAATAGACTTCGGCAATACAACAAGATCGCCAGCCTTGAAGGGCCCATATTCTCTCAAATTTTCATCCAAT
ATTTTGGGAATATCAACTCT

Product: efflux transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNREKAIVIQGLRGRVGKVKRRSTARRNMIFLAIAMFFANISWGIAFPYLGVYMRIIGGSVFLVGLLSVIFNITSTVFQY
PFGYLSDRTGKRKPFIALGILSSGGTYALIAFISSPILLLGLRGLQGALSASLSPAHSALISELATRVGSAFGFFNFVEN
LGYMVGNFLGGFIVQYLDIKSAFFIASAFSLLSILFLLPIRERVSNRKSVQGLIIVQEGRESEKVEMKRMAFKRLMRGKL
GLFYISVFLAMIASGEVYSTISVYFEEKFGENFVGIFFGIDSLAAALSSLVIGRLIDRWGAEVFYKLSLIGYTFTFLGYA
FVNDPITMGIVSVFSGIKWAMFISSVSTYVAKKVPSSERGQGMGLLNTMMSLGWVLGPLIGGYLADISFRIMLYSTVVPL
LLAFTIVSIPYPRHPSE

Sequences:

>Translated_417_residues
MNREKAIVIQGLRGRVGKVKRRSTARRNMIFLAIAMFFANISWGIAFPYLGVYMRIIGGSVFLVGLLSVIFNITSTVFQY
PFGYLSDRTGKRKPFIALGILSSGGTYALIAFISSPILLLGLRGLQGALSASLSPAHSALISELATRVGSAFGFFNFVEN
LGYMVGNFLGGFIVQYLDIKSAFFIASAFSLLSILFLLPIRERVSNRKSVQGLIIVQEGRESEKVEMKRMAFKRLMRGKL
GLFYISVFLAMIASGEVYSTISVYFEEKFGENFVGIFFGIDSLAAALSSLVIGRLIDRWGAEVFYKLSLIGYTFTFLGYA
FVNDPITMGIVSVFSGIKWAMFISSVSTYVAKKVPSSERGQGMGLLNTMMSLGWVLGPLIGGYLADISFRIMLYSTVVPL
LLAFTIVSIPYPRHPSE
>Mature_417_residues
MNREKAIVIQGLRGRVGKVKRRSTARRNMIFLAIAMFFANISWGIAFPYLGVYMRIIGGSVFLVGLLSVIFNITSTVFQY
PFGYLSDRTGKRKPFIALGILSSGGTYALIAFISSPILLLGLRGLQGALSASLSPAHSALISELATRVGSAFGFFNFVEN
LGYMVGNFLGGFIVQYLDIKSAFFIASAFSLLSILFLLPIRERVSNRKSVQGLIIVQEGRESEKVEMKRMAFKRLMRGKL
GLFYISVFLAMIASGEVYSTISVYFEEKFGENFVGIFFGIDSLAAALSSLVIGRLIDRWGAEVFYKLSLIGYTFTFLGYA
FVNDPITMGIVSVFSGIKWAMFISSVSTYVAKKVPSSERGQGMGLLNTMMSLGWVLGPLIGGYLADISFRIMLYSTVVPL
LLAFTIVSIPYPRHPSE

Specific function: Efflux pump for various substrates [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=388, Percent_Identity=23.4536082474227, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45908; Mature: 45908

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREKAIVIQGLRGRVGKVKRRSTARRNMIFLAIAMFFANISWGIAFPYLGVYMRIIGGS
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLVGLLSVIFNITSTVFQYPFGYLSDRTGKRKPFIALGILSSGGTYALIAFISSPILLL
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHHHH
GLRGLQGALSASLSPAHSALISELATRVGSAFGFFNFVENLGYMVGNFLGGFIVQYLDIK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAFFIASAFSLLSILFLLPIRERVSNRKSVQGLIIVQEGRESEKVEMKRMAFKRLMRGKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCH
GLFYISVFLAMIASGEVYSTISVYFEEKFGENFVGIFFGIDSLAAALSSLVIGRLIDRWG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVFYKLSLIGYTFTFLGYAFVNDPITMGIVSVFSGIKWAMFISSVSTYVAKKVPSSERG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGMGLLNTMMSLGWVLGPLIGGYLADISFRIMLYSTVVPLLLAFTIVSIPYPRHPSE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNREKAIVIQGLRGRVGKVKRRSTARRNMIFLAIAMFFANISWGIAFPYLGVYMRIIGGS
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLVGLLSVIFNITSTVFQYPFGYLSDRTGKRKPFIALGILSSGGTYALIAFISSPILLL
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHHHH
GLRGLQGALSASLSPAHSALISELATRVGSAFGFFNFVENLGYMVGNFLGGFIVQYLDIK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAFFIASAFSLLSILFLLPIRERVSNRKSVQGLIIVQEGRESEKVEMKRMAFKRLMRGKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCH
GLFYISVFLAMIASGEVYSTISVYFEEKFGENFVGIFFGIDSLAAALSSLVIGRLIDRWG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVFYKLSLIGYTFTFLGYAFVNDPITMGIVSVFSGIKWAMFISSVSTYVAKKVPSSERG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGMGLLNTMMSLGWVLGPLIGGYLADISFRIMLYSTVVPLLLAFTIVSIPYPRHPSE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]