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The map label for this gene is aspC

Identifier: 18977241

GI number: 18977241

Start: 842922

End: 844238

Strand: Direct

Name: aspC

Synonym: PF0869

Alternate gene names: 18977241

Gene position: 842922-844238 (Clockwise)

Preceding gene: 18977240

Following gene: 18977246

Centisome position: 44.17

GC content: 39.86

Gene sequence:

>1317_bases
ATGTTAAGAACACATTATTCTAACGAGATTACTGAGGAGCTTAATGGTAAAAGAGTAAAAGTTGCAGGATGGGTTCAAGA
AGTAAAAGACCTCGGTGGAATAAAATTTGTGTGGATTAGGGACAGAGAAGGGATTGTTCAAATAACTGCACCAAAAAAGA
AAGTCAGTGAGGAGATATTCAAACTTATTCCAAAGCTTAACAGTGAGGATGTAGTAGTTGTTGAAGGCATCGTGAACTTC
ACTCCAAAAGCAAAGCTTGGATTTGAGATAATTCCAGAGAAGTTTGAGATACTTAACAGAACCCAGACTCCCCTTCCCTT
AGATCCAACAGGGAAAGTAAAAGCCGAGCTTGATACCAGGCTTGACAATAGGTTTATTGATCTTAGAAATCCAAAGGTAA
TGGCAATCTTCAAAATAAGGTCTAATGTGTTCAGGGCAATAAGAGAGTTCTTCTATAATGAAGGATTTATAGAAATACAC
ACTCCAAAAATTATAGCAACGGCCACTGAAGGTGGAACGGAATTATTCCCAATTAAGTATTTTGAGAACGATGCATTCCT
TGCTCAATCACCTCAGCTGTACAAGCAGATCATGATGGCCACTGGGCTGGATAAAGTTTTTGAAACAGCTCCCATCTTTA
GGGCTGAGGAGCACAATACGACCAGACATCTAAACGAGGCTTGGAGTATAGATGCAGAGATAGCGTTCATTGAAAATGAA
GAGGAAGTAATGGATGTTCTTGAAAACTTAGTTGTTTATGCAATCAACTATGTGAGAGAGCACAATGAGAGGGAGCTAAA
GATTCTTGAATTCGAGCTTGAAGAACCGAAGCAACCATTTCCTAGGGTAACATACGATAAAGCCCTTGAAATTTTGTCTG
ACTTAGGAAAAGAAATTCCATGGGGGGAAGACATAGATACCGAGGGAGAGAAATTACTTGGGAAGTACATGAGCGAAAAT
GAAGGGGTAGAGCTTTACTTCATCTACAAATACCCAAGCGAGGCGAAGCCTTTCTATATTATGAAATATGATGAAAAGCC
AGAGATATGTAGGGCTTTTGATCTCGAATACAGGGGAATAGAGATAAGTTCAGGAGGGCAGAGAGAGCACAGATATGAGG
TGTTGCTAGAGCAGATAAAAGAGAAGGGACTAAACCCAGAAAGCTTTGAGTTTTACTTGAAAGCCTTCAAATATGGAATG
CCCCCTCATGGTGGATTTGGACTTGGAGCTGAGAGGTTAATAATGAGAATGCTGAATATAGGAAATATAAGGGAGGTAAT
TCTATTCCCCAGGGACAGAAAGAGGTTAATTCCCTGA

Upstream 100 bases:

>100_bases
ACCTTGTGACGAATGTATAGAGAACCAATGGCTCTTCTGATTTCTTCTCTTTTTTCTTAAAATTTAAAAACAACTTGCCA
TCTTTTGTTTGGGGGTTAAG

Downstream 100 bases:

>100_bases
CTATTCTTTCCCTTTATGCTCGCACCACTCCATGTTTTCCCATTTTCCATGCATCTCTCCAGGTATGTGGCCCGTATCTG
CAACGGCCTCATTTAGGTCG

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLRTHYSNEITEELNGKRVKVAGWVQEVKDLGGIKFVWIRDREGIVQITAPKKKVSEEIFKLIPKLNSEDVVVVEGIVNF
TPKAKLGFEIIPEKFEILNRTQTPLPLDPTGKVKAELDTRLDNRFIDLRNPKVMAIFKIRSNVFRAIREFFYNEGFIEIH
TPKIIATATEGGTELFPIKYFENDAFLAQSPQLYKQIMMATGLDKVFETAPIFRAEEHNTTRHLNEAWSIDAEIAFIENE
EEVMDVLENLVVYAINYVREHNERELKILEFELEEPKQPFPRVTYDKALEILSDLGKEIPWGEDIDTEGEKLLGKYMSEN
EGVELYFIYKYPSEAKPFYIMKYDEKPEICRAFDLEYRGIEISSGGQREHRYEVLLEQIKEKGLNPESFEFYLKAFKYGM
PPHGGFGLGAERLIMRMLNIGNIREVILFPRDRKRLIP

Sequences:

>Translated_438_residues
MLRTHYSNEITEELNGKRVKVAGWVQEVKDLGGIKFVWIRDREGIVQITAPKKKVSEEIFKLIPKLNSEDVVVVEGIVNF
TPKAKLGFEIIPEKFEILNRTQTPLPLDPTGKVKAELDTRLDNRFIDLRNPKVMAIFKIRSNVFRAIREFFYNEGFIEIH
TPKIIATATEGGTELFPIKYFENDAFLAQSPQLYKQIMMATGLDKVFETAPIFRAEEHNTTRHLNEAWSIDAEIAFIENE
EEVMDVLENLVVYAINYVREHNERELKILEFELEEPKQPFPRVTYDKALEILSDLGKEIPWGEDIDTEGEKLLGKYMSEN
EGVELYFIYKYPSEAKPFYIMKYDEKPEICRAFDLEYRGIEISSGGQREHRYEVLLEQIKEKGLNPESFEFYLKAFKYGM
PPHGGFGLGAERLIMRMLNIGNIREVILFPRDRKRLIP
>Mature_438_residues
MLRTHYSNEITEELNGKRVKVAGWVQEVKDLGGIKFVWIRDREGIVQITAPKKKVSEEIFKLIPKLNSEDVVVVEGIVNF
TPKAKLGFEIIPEKFEILNRTQTPLPLDPTGKVKAELDTRLDNRFIDLRNPKVMAIFKIRSNVFRAIREFFYNEGFIEIH
TPKIIATATEGGTELFPIKYFENDAFLAQSPQLYKQIMMATGLDKVFETAPIFRAEEHNTTRHLNEAWSIDAEIAFIENE
EEVMDVLENLVVYAINYVREHNERELKILEFELEEPKQPFPRVTYDKALEILSDLGKEIPWGEDIDTEGEKLLGKYMSEN
EGVELYFIYKYPSEAKPFYIMKYDEKPEICRAFDLEYRGIEISSGGQREHRYEVLLEQIKEKGLNPESFEFYLKAFKYGM
PPHGGFGLGAERLIMRMLNIGNIREVILFPRDRKRLIP

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI45439306, Length=445, Percent_Identity=35.7303370786517, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI4758762, Length=447, Percent_Identity=31.5436241610738, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI226491502, Length=453, Percent_Identity=30.4635761589404, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI40789249, Length=310, Percent_Identity=28.7096774193548, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI194272210, Length=482, Percent_Identity=25.5186721991701, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI5031815, Length=482, Percent_Identity=25.5186721991701, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1787161, Length=448, Percent_Identity=29.4642857142857, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788173, Length=259, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1790571, Length=480, Percent_Identity=27.5, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789256, Length=473, Percent_Identity=26.0042283298097, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87082379, Length=320, Percent_Identity=26.5625, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551876, Length=452, Percent_Identity=33.8495575221239, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71984122, Length=436, Percent_Identity=30.2752293577982, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17556372, Length=413, Percent_Identity=27.8450363196126, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32566633, Length=336, Percent_Identity=27.9761904761905, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994340, Length=471, Percent_Identity=27.1762208067941, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17535925, Length=471, Percent_Identity=27.1762208067941, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17535927, Length=471, Percent_Identity=27.1762208067941, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323011, Length=453, Percent_Identity=37.0860927152318, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6321807, Length=439, Percent_Identity=28.7015945330296, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6319872, Length=469, Percent_Identity=26.865671641791, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320242, Length=472, Percent_Identity=26.6949152542373, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325153, Length=253, Percent_Identity=32.4110671936759, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17136276, Length=460, Percent_Identity=34.7826086956522, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI19921528, Length=439, Percent_Identity=30.751708428246, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI19922416, Length=456, Percent_Identity=25.8771929824561, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24640851, Length=487, Percent_Identity=27.7207392197125, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640849, Length=487, Percent_Identity=27.7207392197125, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24584738, Length=300, Percent_Identity=29, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYD_PYRFU (Q8U2G6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578598.1
- ProteinModelPortal:   Q8U2G6
- SMR:   Q8U2G6
- EnsemblBacteria:   EBPYRT00000005798
- GeneID:   1468729
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0869
- NMPDR:   fig|186497.1.peg.900
- GeneTree:   EBGT00050000022464
- HOGENOM:   HBG745843
- OMA:   ASAFPRD
- ProtClustDB:   PRK05159
- BRENDA:   6.1.1.12
- GO:   GO:0005737
- HAMAP:   MF_00044_A
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020780
- InterPro:   IPR004523
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00458

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 51017; Mature: 51017

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTHYSNEITEELNGKRVKVAGWVQEVKDLGGIKFVWIRDREGIVQITAPKKKVSEEIF
CCCCCCCCHHHHHHCCCEEEEHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHH
KLIPKLNSEDVVVVEGIVNFTPKAKLGFEIIPEKFEILNRTQTPLPLDPTGKVKAELDTR
HHHCCCCCCCEEEEEECCCCCCCCCCCCEECCHHHHHHCCCCCCCCCCCCCCEEHHHHHH
LDNRFIDLRNPKVMAIFKIRSNVFRAIREFFYNEGFIEIHTPKIIATATEGGTELFPIKY
HCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCEEEEEEE
FENDAFLAQSPQLYKQIMMATGLDKVFETAPIFRAEEHNTTRHLNEAWSIDAEIAFIENE
ECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCEECCCCCHHHHHHHHHCCCEEEEEECCH
EEVMDVLENLVVYAINYVREHNERELKILEFELEEPKQPFPRVTYDKALEILSDLGKEIP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
WGEDIDTEGEKLLGKYMSENEGVELYFIYKYPSEAKPFYIMKYDEKPEICRAFDLEYRGI
CCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCEECCE
EISSGGQREHRYEVLLEQIKEKGLNPESFEFYLKAFKYGMPPHGGFGLGAERLIMRMLNI
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
GNIREVILFPRDRKRLIP
CCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLRTHYSNEITEELNGKRVKVAGWVQEVKDLGGIKFVWIRDREGIVQITAPKKKVSEEIF
CCCCCCCCHHHHHHCCCEEEEHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHH
KLIPKLNSEDVVVVEGIVNFTPKAKLGFEIIPEKFEILNRTQTPLPLDPTGKVKAELDTR
HHHCCCCCCCEEEEEECCCCCCCCCCCCEECCHHHHHHCCCCCCCCCCCCCCEEHHHHHH
LDNRFIDLRNPKVMAIFKIRSNVFRAIREFFYNEGFIEIHTPKIIATATEGGTELFPIKY
HCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCEEEEEEE
FENDAFLAQSPQLYKQIMMATGLDKVFETAPIFRAEEHNTTRHLNEAWSIDAEIAFIENE
ECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCEECCCCCHHHHHHHHHCCCEEEEEECCH
EEVMDVLENLVVYAINYVREHNERELKILEFELEEPKQPFPRVTYDKALEILSDLGKEIP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
WGEDIDTEGEKLLGKYMSENEGVELYFIYKYPSEAKPFYIMKYDEKPEICRAFDLEYRGI
CCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCEECCE
EISSGGQREHRYEVLLEQIKEKGLNPESFEFYLKAFKYGMPPHGGFGLGAERLIMRMLNI
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
GNIREVILFPRDRKRLIP
CCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA