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The map label for this gene is mpg1 [H]

Identifier: 18977240

GI number: 18977240

Start: 841620

End: 842861

Strand: Direct

Name: mpg1 [H]

Synonym: PF0868

Alternate gene names: 18977240

Gene position: 841620-842861 (Clockwise)

Preceding gene: 18977238

Following gene: 18977241

Centisome position: 44.1

GC content: 42.51

Gene sequence:

>1242_bases
ATGAAAGCTGTTATTCTTGCTGGAGGTTTTGGAACTAGATTAAGGCCTATTTCATCAACAAGGCCAAAACCTATGGTTCC
TGTACTCGGGAAGCCAAATCTTCAGTACATTCTTGAAGCCCTAGAAAAAGTCAGCGAGATAGATGAGATAATACTCTCCG
TTCACTATATGAGAGGAGAAATAAGAGAGTTCATTCAAGAGAGGATGGTTGATTATCCTAAGGACATTAGATTCGTAAAT
GACCCAATGCCTTTGGAAACTGGTGGAGCATTAAAGAACGTTGAGGATTACGTGAGCGACGACTTCCTAGTAATATATGG
CGATGTGTTTACGAACTTTGATTATTCAGAACTGATTAAGGCTCACAAAGAGAACGACGGTCTCATAACAGTCGCCCTAA
CGAAGGTTTATGACCCAGAGAGGTTTGGTGTGGTCATCGTAGATGAAGAAGGAAAGATTATTGACTTCGAGGAGAAGCCA
AGGAAACCCAAGACCAACTTGGTTGATGCTGGAATATACATGGTTAACAAGGAAGTCCTCAAGGAGATTCCCAAAAACAA
GGAGGTTTACTTTGAGAGGGAGATCCTTCCAAAGTTCGTCAGCCAAGGACTAGTCTACGGATACAGGATGCCAAAGGAAT
ACTACTGGATTGATCTTGGAACGCCTGAAGACCTATTCTATGCCCACCAAATTGCTCTCGATCAGCTTTCAAGGGAAAAT
GGCTACATGATCTTGGGAGAAAATGTTGAAATTCCAGAGGATGTCGAAGTCCAGGGCCCAGTTTACATTGATAACAATGC
AAAGATTGGCCACGGAGTTAAGATTAAGGCCTACACTTACATTGGGCCAAACACCATCATTGAAGATAAGGCTTATATAA
AGAGGTCTATCCTCCTGGGAAGCGACATAATAAAGGAGAGAGCAGAGCTCAAGGATACAATCCTGGGAGAGGGAGTTGTT
GTTGGGAAGAATGTAATCATAAAGGAGAATGCAGTGGTTGGGGATTATGCAAGGATTAACGACAATCTTGTAATCTATGG
AGCAAAGATCTTACCATGGAAGAAAGTTGAGGAGTATGAAGCTTACATAAGAATAAAGCTAGATCCGACAAAAGTCAGGC
CAGAACTAACCCCTGAGAGGTGTCCACTTGGCCTCCCAGAGTGTATATACAAGAAGTTCAAGGCAATTGCTGGTGAAAAG
CCACCTTGTGACGAATGTATAGAGAACCAATGGCTCTTCTGA

Upstream 100 bases:

>100_bases
CGTAAAGATTTGTTATTATGACAATAATTTTGAGCAAAAATTAACCACATTTGAGTAAAATTTTATAAAAAAGAAGAGCT
AAATTACAAATGGTGATATC

Downstream 100 bases:

>100_bases
TTTCTTCTCTTTTTTCTTAAAATTTAAAAACAACTTGCCATCTTTTGTTTGGGGGTTAAGATGTTAAGAACACATTATTC
TAACGAGATTACTGAGGAGC

Product: NDP-sugar synthase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYILEALEKVSEIDEIILSVHYMRGEIREFIQERMVDYPKDIRFVN
DPMPLETGGALKNVEDYVSDDFLVIYGDVFTNFDYSELIKAHKENDGLITVALTKVYDPERFGVVIVDEEGKIIDFEEKP
RKPKTNLVDAGIYMVNKEVLKEIPKNKEVYFEREILPKFVSQGLVYGYRMPKEYYWIDLGTPEDLFYAHQIALDQLSREN
GYMILGENVEIPEDVEVQGPVYIDNNAKIGHGVKIKAYTYIGPNTIIEDKAYIKRSILLGSDIIKERAELKDTILGEGVV
VGKNVIIKENAVVGDYARINDNLVIYGAKILPWKKVEEYEAYIRIKLDPTKVRPELTPERCPLGLPECIYKKFKAIAGEK
PPCDECIENQWLF

Sequences:

>Translated_413_residues
MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYILEALEKVSEIDEIILSVHYMRGEIREFIQERMVDYPKDIRFVN
DPMPLETGGALKNVEDYVSDDFLVIYGDVFTNFDYSELIKAHKENDGLITVALTKVYDPERFGVVIVDEEGKIIDFEEKP
RKPKTNLVDAGIYMVNKEVLKEIPKNKEVYFEREILPKFVSQGLVYGYRMPKEYYWIDLGTPEDLFYAHQIALDQLSREN
GYMILGENVEIPEDVEVQGPVYIDNNAKIGHGVKIKAYTYIGPNTIIEDKAYIKRSILLGSDIIKERAELKDTILGEGVV
VGKNVIIKENAVVGDYARINDNLVIYGAKILPWKKVEEYEAYIRIKLDPTKVRPELTPERCPLGLPECIYKKFKAIAGEK
PPCDECIENQWLF
>Mature_413_residues
MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYILEALEKVSEIDEIILSVHYMRGEIREFIQERMVDYPKDIRFVN
DPMPLETGGALKNVEDYVSDDFLVIYGDVFTNFDYSELIKAHKENDGLITVALTKVYDPERFGVVIVDEEGKIIDFEEKP
RKPKTNLVDAGIYMVNKEVLKEIPKNKEVYFEREILPKFVSQGLVYGYRMPKEYYWIDLGTPEDLFYAHQIALDQLSREN
GYMILGENVEIPEDVEVQGPVYIDNNAKIGHGVKIKAYTYIGPNTIIEDKAYIKRSILLGSDIIKERAELKDTILGEGVV
VGKNVIIKENAVVGDYARINDNLVIYGAKILPWKKVEEYEAYIRIKLDPTKVRPELTPERCPLGLPECIYKKFKAIAGEK
PPCDECIENQWLF

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=366, Percent_Identity=30.327868852459, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI11761619, Length=389, Percent_Identity=28.5347043701799, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI31881779, Length=359, Percent_Identity=23.6768802228412, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI45447090, Length=359, Percent_Identity=23.6768802228412, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788351, Length=261, Percent_Identity=28.735632183908, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789837, Length=386, Percent_Identity=25.1295336787565, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790224, Length=250, Percent_Identity=26, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=360, Percent_Identity=31.3888888888889, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509979, Length=334, Percent_Identity=27.8443113772455, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17509981, Length=321, Percent_Identity=26.791277258567, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320148, Length=364, Percent_Identity=33.5164835164835, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6320417, Length=402, Percent_Identity=21.3930348258706, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355443, Length=358, Percent_Identity=32.9608938547486, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24644084, Length=358, Percent_Identity=32.9608938547486, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24653912, Length=366, Percent_Identity=23.4972677595628, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 47221; Mature: 47221

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYILEALEKVSEIDEIILSVHYMRGE
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IREFIQERMVDYPKDIRFVNDPMPLETGGALKNVEDYVSDDFLVIYGDVFTNFDYSELIK
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCCHHHHHH
AHKENDGLITVALTKVYDPERFGVVIVDEEGKIIDFEEKPRKPKTNLVDAGIYMVNKEVL
HHCCCCCEEEEEEEEECCCCCCCEEEECCCCCEECCCCCCCCCCCCEEECHHEEECHHHH
KEIPKNKEVYFEREILPKFVSQGLVYGYRMPKEYYWIDLGTPEDLFYAHQIALDQLSREN
HHCCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
GYMILGENVEIPEDVEVQGPVYIDNNAKIGHGVKIKAYTYIGPNTIIEDKAYIKRSILLG
CEEEECCCCCCCCCCEECCCEEECCCCCCCCCEEEEEEEEECCCCEECCHHHHHHHHHHC
SDIIKERAELKDTILGEGVVVGKNVIIKENAVVGDYARINDNLVIYGAKILPWKKVEEYE
HHHHHHHHHHHHHHHCCCEEECCEEEEECCCEECCCEEECCCEEEEEEEECCCHHHCCEE
AYIRIKLDPTKVRPELTPERCPLGLPECIYKKFKAIAGEKPPCDECIENQWLF
EEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYILEALEKVSEIDEIILSVHYMRGE
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IREFIQERMVDYPKDIRFVNDPMPLETGGALKNVEDYVSDDFLVIYGDVFTNFDYSELIK
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCCHHHHHH
AHKENDGLITVALTKVYDPERFGVVIVDEEGKIIDFEEKPRKPKTNLVDAGIYMVNKEVL
HHCCCCCEEEEEEEEECCCCCCCEEEECCCCCEECCCCCCCCCCCCEEECHHEEECHHHH
KEIPKNKEVYFEREILPKFVSQGLVYGYRMPKEYYWIDLGTPEDLFYAHQIALDQLSREN
HHCCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
GYMILGENVEIPEDVEVQGPVYIDNNAKIGHGVKIKAYTYIGPNTIIEDKAYIKRSILLG
CEEEECCCCCCCCCCEECCCEEECCCCCCCCCEEEEEEEEECCCCEECCHHHHHHHHHHC
SDIIKERAELKDTILGEGVVVGKNVIIKENAVVGDYARINDNLVIYGAKILPWKKVEEYE
HHHHHHHHHHHHHHHCCCEEECCEEEEECCCEECCCEEECCCEEEEEEEECCCHHHCCEE
AYIRIKLDPTKVRPELTPERCPLGLPECIYKKFKAIAGEKPPCDECIENQWLF
EEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]