Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 18977196

GI number: 18977196

Start: 802087

End: 803559

Strand: Direct

Name: norM [H]

Synonym: PF0824

Alternate gene names: 18977196

Gene position: 802087-803559 (Clockwise)

Preceding gene: 18977195

Following gene: 18977205

Centisome position: 42.03

GC content: 45.42

Gene sequence:

>1473_bases
GTGTTATTGAGGAGCACCACTGACGTGGTAAAAATGGAGCGCGGAAAGATTCAAGCGATGCGAGAGCAAATCCTTAATGG
TCCAATAGAAAAGACTCTCATCAAGTTAGCGTATCCTTTAATCATTAGCAACCTTGTTCAGGTTCTATACAACATAACAG
ACACATTTTGGCTTGGAAAGCTTGGGAGAGAAGCTCTAGCTGCTCCTGGGACAAGTTGGCCAATAATCGGGACACTAATG
GCTCTTGGTATGGGGTTTGCAACAGCTGGCTTCGCCTTCATTGGGCAGTATATAGGGGCTGGAGAGTACGAGAGGGCCAA
CCGCTCCGCTGGAGCCCTTTACTCTCTCATGCTTCTTTTTTCAACCCTAACTGCCGCTATAAGTCTTGCTATTCTTCCAT
ATGCTCTTCACTTCATGAAAGTCACTCCAAACGTTTATCCCTATGCAAAGGCCTACGCTACAGTTGTTTTTGCTGGGGTT
CCGTTTTCCTTCACTTTCATAGCCTTTTCAGCTCTAATGAGAGCTGCTGGCGATACAAAAACCCCAGTGAAGATAAGCAT
GCTTACAGTCTTCATGAACATAATCCTTGATCCACTCCTTATATTTGGCATTGGACCCTTCCCAAAGTGGGGGGTTGCTG
GGGCCGCGATAGCTACAGTTCTCTCAAATGCTACTGGAGCTCTTATAGGAGCTTGGCTCTTGACACGTGGAAAACTTGGC
CTTCACCTAACGAGAGAGACCCTCAAGCCAGATTTCCACTTCTACTCGAGGATATTTCGCGTTGGCCTACCAGCAGCAGT
TGGGCAATCAGCGAATAGCTTTGGCTTTGTTTTTCTCACTAGAATTATTTATGGTTATGGGGATGTGGCTTACGCTGCTT
ACACAATAACCACTCGTCTTGTGAACTTTCTAACGAGCATAGCTCGAGGAATAAGCATGGCAATGGGAACCATGGTGGCT
CAGAATATAGGGGCAGAGAAATATGGGAGGGCAAAGAAGATAGCTGAGAGGGCAATGATAACTAACTTCATGATAGCCTC
TCTAGCTGTGCTCATAATTGGGATCTTTAGGGTTCCGATTTTCAGGGTATTCTTGGATGATCCAGAGGTTATTGCCCAGA
GTGAATACGTGCTCAAATACTTCCTGACTTCAGTTCCATTCTTCAACGGAATATTTGTCGTTGTAACGATGACTTTCAGC
TCTGCGGGCCACACAAAGAAGAGAATGATTTTAGATATGCTCCGTCTTTGGGGCTTTAGGATACCTCTAAGCTACATTTT
CGGGTACGTTCCGGGAATTAATCTATTAGGAGTTTGGATACCGCTTGCAGAGCTTTTTGGAATGACTCCAAAGGGCGTGT
TCTTTGGCATGGGCATGAGCAACTTTTTAGCGGCAACAATAGCGCTCATGTGGTTCATGAAGGGTACGTGGATGAAAAGA
ATAATAGAAGAGGATATCAGGAAAGGGTCTTGA

Upstream 100 bases:

>100_bases
ATGAAAGACACTGCAGGAATGTGGCTTGGAATGGGATTAAGTAACGTTATAGGAGCTCTTATAGGCTTGGCTTGGTTCCT
CAAGGGAAGCTGGTTAAGGG

Downstream 100 bases:

>100_bases
GAACAAAGGCCAGGAGATCTGTGAGCTCCCTGGCTCTTGTCTCTGGAGAAGCGCCCATATGACCACTCTTCGTCTCAACT
CTTAGATAAACCGGGGCACC

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLLRSTTDVVKMERGKIQAMREQILNGPIEKTLIKLAYPLIISNLVQVLYNITDTFWLGKLGREALAAPGTSWPIIGTLM
ALGMGFATAGFAFIGQYIGAGEYERANRSAGALYSLMLLFSTLTAAISLAILPYALHFMKVTPNVYPYAKAYATVVFAGV
PFSFTFIAFSALMRAAGDTKTPVKISMLTVFMNIILDPLLIFGIGPFPKWGVAGAAIATVLSNATGALIGAWLLTRGKLG
LHLTRETLKPDFHFYSRIFRVGLPAAVGQSANSFGFVFLTRIIYGYGDVAYAAYTITTRLVNFLTSIARGISMAMGTMVA
QNIGAEKYGRAKKIAERAMITNFMIASLAVLIIGIFRVPIFRVFLDDPEVIAQSEYVLKYFLTSVPFFNGIFVVVTMTFS
SAGHTKKRMILDMLRLWGFRIPLSYIFGYVPGINLLGVWIPLAELFGMTPKGVFFGMGMSNFLAATIALMWFMKGTWMKR
IIEEDIRKGS

Sequences:

>Translated_490_residues
MLLRSTTDVVKMERGKIQAMREQILNGPIEKTLIKLAYPLIISNLVQVLYNITDTFWLGKLGREALAAPGTSWPIIGTLM
ALGMGFATAGFAFIGQYIGAGEYERANRSAGALYSLMLLFSTLTAAISLAILPYALHFMKVTPNVYPYAKAYATVVFAGV
PFSFTFIAFSALMRAAGDTKTPVKISMLTVFMNIILDPLLIFGIGPFPKWGVAGAAIATVLSNATGALIGAWLLTRGKLG
LHLTRETLKPDFHFYSRIFRVGLPAAVGQSANSFGFVFLTRIIYGYGDVAYAAYTITTRLVNFLTSIARGISMAMGTMVA
QNIGAEKYGRAKKIAERAMITNFMIASLAVLIIGIFRVPIFRVFLDDPEVIAQSEYVLKYFLTSVPFFNGIFVVVTMTFS
SAGHTKKRMILDMLRLWGFRIPLSYIFGYVPGINLLGVWIPLAELFGMTPKGVFFGMGMSNFLAATIALMWFMKGTWMKR
IIEEDIRKGS
>Mature_490_residues
MLLRSTTDVVKMERGKIQAMREQILNGPIEKTLIKLAYPLIISNLVQVLYNITDTFWLGKLGREALAAPGTSWPIIGTLM
ALGMGFATAGFAFIGQYIGAGEYERANRSAGALYSLMLLFSTLTAAISLAILPYALHFMKVTPNVYPYAKAYATVVFAGV
PFSFTFIAFSALMRAAGDTKTPVKISMLTVFMNIILDPLLIFGIGPFPKWGVAGAAIATVLSNATGALIGAWLLTRGKLG
LHLTRETLKPDFHFYSRIFRVGLPAAVGQSANSFGFVFLTRIIYGYGDVAYAAYTITTRLVNFLTSIARGISMAMGTMVA
QNIGAEKYGRAKKIAERAMITNFMIASLAVLIIGIFRVPIFRVFLDDPEVIAQSEYVLKYFLTSVPFFNGIFVVVTMTFS
SAGHTKKRMILDMLRLWGFRIPLSYIFGYVPGINLLGVWIPLAELFGMTPKGVFFGMGMSNFLAATIALMWFMKGTWMKR
IIEEDIRKGS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=458, Percent_Identity=21.8340611353712, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 53895; Mature: 53895

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCC
>Mature Secondary Structure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HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]