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The map label for this gene is wecC [H]

Identifier: 18977137

GI number: 18977137

Start: 757388

End: 758677

Strand: Reverse

Name: wecC [H]

Synonym: PF0765

Alternate gene names: 18977137

Gene position: 758677-757388 (Counterclockwise)

Preceding gene: 18977138

Following gene: 18977136

Centisome position: 39.76

GC content: 47.13

Gene sequence:

>1290_bases
GTGACGATAGCGGTTTATGGACTAGGTAAGATGGGGCTTCCCCTAGCTGCAGTCTTCGCCGACCATGGAGCTAACGTCAT
CGGCGTCGACATAAACGAGAGAGTTGTTGAGATGGTAAACAAGGGTGAAAACCACGTTAAAGAGGAACCTGGGTTGGATG
AGCTTGTTAGGAGGAACGTTGAAGAGGGAAGATTAAGGGCCACGACTGACGGTGTTTGGGCCGCAAAGAGTGCCGACGTC
ATGATAATATTGGTTCCAACGTTGGCCGATGATAGGGGAAACCTGAAGCTTGAACCCGTCTACGATGTTGCCAATAAGAT
TGCAAAGGGCTTGGAAAAAGGCGATATAGTAATAACTGAAGCAACTATGCCCCCAGGAACCACGGAGAGCCTTATTCCGA
TACTTGAGAAGTCTGGTCTAAAGCTTGGTGAGTTCGGATTAGCCCACGCTCCAGAGAGGACAATGACCGGAACCGCGATT
AGGGACATTACAGGCCAGTATCCTAAGATAGTTGGAGCGAGCGATGAGAGAACGTTAGAGGCAGTTATCGGATTATACGA
GACGATAAACAGAAAGGGAGTCATTCCAATGAGCTCTATAAAGGCCGCAGAAGCGGTGAAGGTGTTCGAAGGAGTATACA
GGGACGTCAACATAGCATTGGCTAATGAACTTGCATTGTGGTGCGAAGAACATGGGTTAGACGCCTTAGAAATATTCAAC
GCAGCCAACACTCAGCCTTATTGCCATCTACACATGCCAGGAGCCGGGGTTGGGGGGCATTGTATCCCAGTCTATCCCTG
GTTCGTGATAAGCTTGGCTAAAAAGACGAATCCCAGACTGATAAAGACCGCCAGAGAGATAAACGATTCTATGCCCCACC
ACATTGTTGAATTAACAATAAGAGGGCTGAATGAAGTTGGGAAACCATTGAAAGGTAGCAACGTGCTCGTCCTAGGACTA
ACCTTTAGAGGAGGTGTAAGAGAGTTTACGAAGAGCCCTGCAATAGATGTTATAAAGGAGCTCAAGGAATGGGGAGCCAG
AGTCTTTACATACGATCCCCTATGCAATGAGGAAGATGCGAAACGTTTTGGAGCGGAGTGGAAAGAGGACTTCAAGGATG
TAGATGCCATAGTCATAGTTACCGACCACAAGGAGTTCAAGGACTTAAACCTGGAAGAGATAGCAAAGCAGGTAAGAAAC
AGAGTAATCGTTGATGGAAGGAATATTCTAGATCCCAGGAAGGCTGAAAAGCTAGGATTCGTGTATTTAAGGGTTGGGAG
AGTGTTTTAA

Upstream 100 bases:

>100_bases
TTTGGAGAGCTCAAAAAGAGATGAGGTCTTGGAGGTGGAATAATTGAAGCTCCTGGGATTAAGTAGGGAAGAGGTTAAAC
AGGCCTTAAGGGATGGGAAG

Downstream 100 bases:

>100_bases
TAGCATAGCCTTCTCCCTTTTCATATTTGTTAAATATTCGAATCGTGTTTATTATAATCATGATCCGAAAATTTGTGAAC
AGGAAAAGGGAGCTTGAAGT

Product: NDP-sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTIAVYGLGKMGLPLAAVFADHGANVIGVDINERVVEMVNKGENHVKEEPGLDELVRRNVEEGRLRATTDGVWAAKSADV
MIILVPTLADDRGNLKLEPVYDVANKIAKGLEKGDIVITEATMPPGTTESLIPILEKSGLKLGEFGLAHAPERTMTGTAI
RDITGQYPKIVGASDERTLEAVIGLYETINRKGVIPMSSIKAAEAVKVFEGVYRDVNIALANELALWCEEHGLDALEIFN
AANTQPYCHLHMPGAGVGGHCIPVYPWFVISLAKKTNPRLIKTAREINDSMPHHIVELTIRGLNEVGKPLKGSNVLVLGL
TFRGGVREFTKSPAIDVIKELKEWGARVFTYDPLCNEEDAKRFGAEWKEDFKDVDAIVIVTDHKEFKDLNLEEIAKQVRN
RVIVDGRNILDPRKAEKLGFVYLRVGRVF

Sequences:

>Translated_429_residues
MTIAVYGLGKMGLPLAAVFADHGANVIGVDINERVVEMVNKGENHVKEEPGLDELVRRNVEEGRLRATTDGVWAAKSADV
MIILVPTLADDRGNLKLEPVYDVANKIAKGLEKGDIVITEATMPPGTTESLIPILEKSGLKLGEFGLAHAPERTMTGTAI
RDITGQYPKIVGASDERTLEAVIGLYETINRKGVIPMSSIKAAEAVKVFEGVYRDVNIALANELALWCEEHGLDALEIFN
AANTQPYCHLHMPGAGVGGHCIPVYPWFVISLAKKTNPRLIKTAREINDSMPHHIVELTIRGLNEVGKPLKGSNVLVLGL
TFRGGVREFTKSPAIDVIKELKEWGARVFTYDPLCNEEDAKRFGAEWKEDFKDVDAIVIVTDHKEFKDLNLEEIAKQVRN
RVIVDGRNILDPRKAEKLGFVYLRVGRVF
>Mature_428_residues
TIAVYGLGKMGLPLAAVFADHGANVIGVDINERVVEMVNKGENHVKEEPGLDELVRRNVEEGRLRATTDGVWAAKSADVM
IILVPTLADDRGNLKLEPVYDVANKIAKGLEKGDIVITEATMPPGTTESLIPILEKSGLKLGEFGLAHAPERTMTGTAIR
DITGQYPKIVGASDERTLEAVIGLYETINRKGVIPMSSIKAAEAVKVFEGVYRDVNIALANELALWCEEHGLDALEIFNA
ANTQPYCHLHMPGAGVGGHCIPVYPWFVISLAKKTNPRLIKTAREINDSMPHHIVELTIRGLNEVGKPLKGSNVLVLGLT
FRGGVREFTKSPAIDVIKELKEWGARVFTYDPLCNEEDAKRFGAEWKEDFKDVDAIVIVTDHKEFKDLNLEEIAKQVRNR
VIVDGRNILDPRKAEKLGFVYLRVGRVF

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=460, Percent_Identity=23.0434782608696, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI296040438, Length=359, Percent_Identity=21.1699164345404, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI296040443, Length=305, Percent_Identity=21.6393442622951, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994968, Length=426, Percent_Identity=32.3943661971831, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788340, Length=413, Percent_Identity=23.2445520581114, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=459, Percent_Identity=24.8366013071895, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136908, Length=472, Percent_Identity=23.9406779661017, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47258; Mature: 47127

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAVYGLGKMGLPLAAVFADHGANVIGVDINERVVEMVNKGENHVKEEPGLDELVRRNV
CEEEEEECCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCHHHCCCCCHHHHHHCCH
EEGRLRATTDGVWAAKSADVMIILVPTLADDRGNLKLEPVYDVANKIAKGLEKGDIVITE
HCCCEEEECCCCEEECCCCEEEEEEEEECCCCCCEEECHHHHHHHHHHHCCCCCCEEEEE
ATMPPGTTESLIPILEKSGLKLGEFGLAHAPERTMTGTAIRDITGQYPKIVGASDERTLE
CCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCHHHHH
AVIGLYETINRKGVIPMSSIKAAEAVKVFEGVYRDVNIALANELALWCEEHGLDALEIFN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHHH
AANTQPYCHLHMPGAGVGGHCIPVYPWFVISLAKKTNPRLIKTAREINDSMPHHIVELTI
CCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
RGLNEVGKPLKGSNVLVLGLTFRGGVREFTKSPAIDVIKELKEWGARVFTYDPLCNEEDA
HHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHH
KRFGAEWKEDFKDVDAIVIVTDHKEFKDLNLEEIAKQVRNRVIVDGRNILDPRKAEKLGF
HHHCCHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHCCEEECCCCCCCCCHHHHHCE
VYLRVGRVF
EEEEECCCC
>Mature Secondary Structure 
TIAVYGLGKMGLPLAAVFADHGANVIGVDINERVVEMVNKGENHVKEEPGLDELVRRNV
EEEEEECCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCHHHCCCCCHHHHHHCCH
EEGRLRATTDGVWAAKSADVMIILVPTLADDRGNLKLEPVYDVANKIAKGLEKGDIVITE
HCCCEEEECCCCEEECCCCEEEEEEEEECCCCCCEEECHHHHHHHHHHHCCCCCCEEEEE
ATMPPGTTESLIPILEKSGLKLGEFGLAHAPERTMTGTAIRDITGQYPKIVGASDERTLE
CCCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCHHHHH
AVIGLYETINRKGVIPMSSIKAAEAVKVFEGVYRDVNIALANELALWCEEHGLDALEIFN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHHH
AANTQPYCHLHMPGAGVGGHCIPVYPWFVISLAKKTNPRLIKTAREINDSMPHHIVELTI
CCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHH
RGLNEVGKPLKGSNVLVLGLTFRGGVREFTKSPAIDVIKELKEWGARVFTYDPLCNEEDA
HHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHH
KRFGAEWKEDFKDVDAIVIVTDHKEFKDLNLEEIAKQVRNRVIVDGRNILDPRKAEKLGF
HHHCCHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHCCEEECCCCCCCCCHHHHHCE
VYLRVGRVF
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA