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The map label for this gene is purE [H]

Identifier: 18976799

GI number: 18976799

Start: 434901

End: 435413

Strand: Direct

Name: purE [H]

Synonym: PF0427

Alternate gene names: 18976799

Gene position: 434901-435413 (Clockwise)

Preceding gene: 18976798

Following gene: 18976800

Centisome position: 22.79

GC content: 41.13

Gene sequence:

>513_bases
ATGCCTAAAGTTGGAATCATAATGGGTAGTGATTCAGATTTGCCCGTAATGAAGGAAGCAGCTAAAGTTCTGGAAGAGTT
TGGAGTAGATTATGAAATAACAATAGTCTCGGCACACAGAACACCAGAGAGAATGTACGAGTATGCAAAAACTGCCAGAG
AGAGGGGAATTGAAGTTATTATTGCAGGTGCTGGAGGTGCAGCCCATCTTCCTGGAATGACGGCCTCGATAACAACTCTT
CCTGTAATAGGAGTTCCAGTTAAAAGTAGGGCCTTGAATGGACTAGATTCTCTGCTTTCCATAGTTCAAATGCCAGCAGG
TGTTCCTGTTGCTACTGTAGCCATAAACAATGCTAAGAATGCTGCTTTACTTGCTCTCAGAATTCTTTCTATAAAGTATC
CAGAGATTGCCGAAAAACTAGAAAAGTACAAAGAAGAGATGAGAAAAACAGTTGAGGAAAAAGCTAAAAAGCTCGAAGAG
GTTGGTTGGAAAGAATATCTGGGAGAGGAATGA

Upstream 100 bases:

>100_bases
CCTCTAAGAAAGATGGGTCATGTAACCGTCGTAAATAGAAATTTGGAAAAGGCCTTAGAGATTGCCCACAAAGTTAAGAA
GGTAATAAAGGTGGTTGGAG

Downstream 100 bases:

>100_bases
TTTAGTCCTTTTTTAAATATTTTTAGGAGATTTGACAACTTAGATTTGGGAATTTATATAAAGCCTCTTTCAATAGGTTG
TAGTATGATAGAAATCAGAA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MPKVGIIMGSDSDLPVMKEAAKVLEEFGVDYEITIVSAHRTPERMYEYAKTARERGIEVIIAGAGGAAHLPGMTASITTL
PVIGVPVKSRALNGLDSLLSIVQMPAGVPVATVAINNAKNAALLALRILSIKYPEIAEKLEKYKEEMRKTVEEKAKKLEE
VGWKEYLGEE

Sequences:

>Translated_170_residues
MPKVGIIMGSDSDLPVMKEAAKVLEEFGVDYEITIVSAHRTPERMYEYAKTARERGIEVIIAGAGGAAHLPGMTASITTL
PVIGVPVKSRALNGLDSLLSIVQMPAGVPVATVAINNAKNAALLALRILSIKYPEIAEKLEKYKEEMRKTVEEKAKKLEE
VGWKEYLGEE
>Mature_169_residues
PKVGIIMGSDSDLPVMKEAAKVLEEFGVDYEITIVSAHRTPERMYEYAKTARERGIEVIIAGAGGAAHLPGMTASITTLP
VIGVPVKSRALNGLDSLLSIVQMPAGVPVATVAINNAKNAALLALRILSIKYPEIAEKLEKYKEEMRKTVEEKAKKLEEV
GWKEYLGEE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=56.7567567567568, Blast_Score=137, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=166, Percent_Identity=63.855421686747, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18478; Mature: 18347

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVGIIMGSDSDLPVMKEAAKVLEEFGVDYEITIVSAHRTPERMYEYAKTARERGIEVI
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMTASITTLPVIGVPVKSRALNGLDSLLSIVQMPAGVPVATVAINNAKN
EECCCCCCCCCCCCCHHHHCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
AALLALRILSIKYPEIAEKLEKYKEEMRKTVEEKAKKLEEVGWKEYLGEE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
PKVGIIMGSDSDLPVMKEAAKVLEEFGVDYEITIVSAHRTPERMYEYAKTARERGIEVI
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMTASITTLPVIGVPVKSRALNGLDSLLSIVQMPAGVPVATVAINNAKN
EECCCCCCCCCCCCCHHHHCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
AALLALRILSIKYPEIAEKLEKYKEEMRKTVEEKAKKLEEVGWKEYLGEE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]