Click here to switch to the map view.

The map label for this gene is appC [H]

Identifier: 18976731

GI number: 18976731

Start: 373064

End: 373978

Strand: Direct

Name: appC [H]

Synonym: PF0359

Alternate gene names: 18976731

Gene position: 373064-373978 (Clockwise)

Preceding gene: 18976730

Following gene: 18976732

Centisome position: 19.55

GC content: 41.09

Gene sequence:

>915_bases
ATGAAAACAATAAAGCTCGCATTCAAAAATAACAAATTTAAATTTGGATTTGGAATATTAGTAGCTTTTATAATCTTTGG
GCTAATTGGCCCGCTTTTTACTCCCTTTGCAAATGATGGATTGTATTATGAACAAGTAGGTAGAATCAAGATTGCATCAT
ACTCAACCAAAACTCTTCCTCCAATGACCAGGGAAAACATAACCACGTACACAGGAAAAAGCATCGAAGTCCTACACATC
CTCGGAACAGACAAGGAAGGAAAAGACCTCTACACCCAGCTTGTCTATGGCCTCAGAACATCTCTGTGGATAGCGTTTTT
GGCCGCAATAATAGGAACTCTAATGGGAATAACAATAGGGTTTGTCTCAGGCTACAAGGGAGGAATAGTAGACGAAATCT
TAATGATGCTTGTCAACATAATGCTGGTAATCCCCTCAATAGTACTTTTAATCCTAGTGGCTGCTTATCTTGAGGCCAGA
AGTCCTGAGATTCAAGCTATTATAATAGGATTAACAAACTGGCCATGGGTTGCCAGGTCAGTTAGAGCACAAACGCTCTC
GCTAAAGAATAGGGAGTTTGTCTACCTCTCTAAGATAATGGGGCTTGAAGACCTTAGGATAATAATAGAAGACATTCTTC
CAAACATGATATCTTACATCTTCATGGCCGGAATTCTCCAAGTTAGTGGGGCAGTCTTAGCTTCAGCAACTCTAGATTTC
ATAGGACTAGGACCAACTACTATGGTTTCCCTGGGGGTAATCCTTCAGAAAGCAATTATGCACAATGCCCTTCAGTTCGG
CTGGTGGTGGTGGTTCATTCCACCAGGATTGTTTATAACTCTCATAATCACAGCGTTGTTCTTTGTGAATCTCGGTCTTG
AGGAGGTTTTTAATCCGAGGTTGAGGAGGGAGTGA

Upstream 100 bases:

>100_bases
AATGATCGTAATCTCAGTTCTCGTCGCCAACTTCCTGATAGATATCGCCTATGCCTTCATTGATCCACGTGTTAGGGCTA
GCTATACGGAGGGATGATAA

Downstream 100 bases:

>100_bases
TTGTGCTTGAGGTGAGGAATCTCAGGATTTATTATTCAACTCCAGTTGGTTTTGTAAAAGCAGTTGATGGAGTAAGTTTC
GAAGTCAAGAAGGGGGAAGT

Product: oligopeptide ABC transport system permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKTIKLAFKNNKFKFGFGILVAFIIFGLIGPLFTPFANDGLYYEQVGRIKIASYSTKTLPPMTRENITTYTGKSIEVLHI
LGTDKEGKDLYTQLVYGLRTSLWIAFLAAIIGTLMGITIGFVSGYKGGIVDEILMMLVNIMLVIPSIVLLILVAAYLEAR
SPEIQAIIIGLTNWPWVARSVRAQTLSLKNREFVYLSKIMGLEDLRIIIEDILPNMISYIFMAGILQVSGAVLASATLDF
IGLGPTTMVSLGVILQKAIMHNALQFGWWWWFIPPGLFITLIITALFFVNLGLEEVFNPRLRRE

Sequences:

>Translated_304_residues
MKTIKLAFKNNKFKFGFGILVAFIIFGLIGPLFTPFANDGLYYEQVGRIKIASYSTKTLPPMTRENITTYTGKSIEVLHI
LGTDKEGKDLYTQLVYGLRTSLWIAFLAAIIGTLMGITIGFVSGYKGGIVDEILMMLVNIMLVIPSIVLLILVAAYLEAR
SPEIQAIIIGLTNWPWVARSVRAQTLSLKNREFVYLSKIMGLEDLRIIIEDILPNMISYIFMAGILQVSGAVLASATLDF
IGLGPTTMVSLGVILQKAIMHNALQFGWWWWFIPPGLFITLIITALFFVNLGLEEVFNPRLRRE
>Mature_304_residues
MKTIKLAFKNNKFKFGFGILVAFIIFGLIGPLFTPFANDGLYYEQVGRIKIASYSTKTLPPMTRENITTYTGKSIEVLHI
LGTDKEGKDLYTQLVYGLRTSLWIAFLAAIIGTLMGITIGFVSGYKGGIVDEILMMLVNIMLVIPSIVLLILVAAYLEAR
SPEIQAIIIGLTNWPWVARSVRAQTLSLKNREFVYLSKIMGLEDLRIIIEDILPNMISYIFMAGILQVSGAVLASATLDF
IGLGPTTMVSLGVILQKAIMHNALQFGWWWWFIPPGLFITLIITALFFVNLGLEEVFNPRLRRE

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=231, Percent_Identity=34.1991341991342, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787054, Length=259, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787498, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787760, Length=226, Percent_Identity=28.7610619469027, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789889, Length=235, Percent_Identity=28.5106382978723, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788505, Length=259, Percent_Identity=27.7992277992278, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787549, Length=171, Percent_Identity=26.9005847953216, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33977; Mature: 33977

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIKLAFKNNKFKFGFGILVAFIIFGLIGPLFTPFANDGLYYEQVGRIKIASYSTKTLP
CCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCCCCC
PMTRENITTYTGKSIEVLHILGTDKEGKDLYTQLVYGLRTSLWIAFLAAIIGTLMGITIG
CCCCCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVSGYKGGIVDEILMMLVNIMLVIPSIVLLILVAAYLEARSPEIQAIIIGLTNWPWVARS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
VRAQTLSLKNREFVYLSKIMGLEDLRIIIEDILPNMISYIFMAGILQVSGAVLASATLDF
HHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLGPTTMVSLGVILQKAIMHNALQFGWWWWFIPPGLFITLIITALFFVNLGLEEVFNPR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCCHHHHCCCH
LRRE
HCCC
>Mature Secondary Structure
MKTIKLAFKNNKFKFGFGILVAFIIFGLIGPLFTPFANDGLYYEQVGRIKIASYSTKTLP
CCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCCCCC
PMTRENITTYTGKSIEVLHILGTDKEGKDLYTQLVYGLRTSLWIAFLAAIIGTLMGITIG
CCCCCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVSGYKGGIVDEILMMLVNIMLVIPSIVLLILVAAYLEARSPEIQAIIIGLTNWPWVARS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
VRAQTLSLKNREFVYLSKIMGLEDLRIIIEDILPNMISYIFMAGILQVSGAVLASATLDF
HHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLGPTTMVSLGVILQKAIMHNALQFGWWWWFIPPGLFITLIITALFFVNLGLEEVFNPR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCCHHHHCCCH
LRRE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]