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The map label for this gene is trpA [H]

Identifier: 189424303

GI number: 189424303

Start: 1285626

End: 1286423

Strand: Reverse

Name: trpA [H]

Synonym: Glov_1238

Alternate gene names: 189424303

Gene position: 1286423-1285626 (Counterclockwise)

Preceding gene: 189424304

Following gene: 189424302

Centisome position: 32.84

GC content: 59.9

Gene sequence:

>798_bases
ATGAAAAGCCGTATTCACAACCGCTTCACCCAATTACACAAGCAGGGCGGCAAGGCCCTGGTCACCTTTATCACCGCCGG
GGACCCCGATCTGGCCACCACAGCAGCCCTGCTGCCGCGCATGGCAGAGGCCGGTGCCGACATCATTGAACTCGGCATCC
CATTTTCCGACCCGATGGCTGACGGCCCCACCATTCAGCGTGCCTCGGAGCGGGCTCTGGCTCAGGGTGTCACCCTCGAG
GCGGTCCTTGCAATGGTCAGCCAGGTCAGAGAGCAGGTTTCGGCACCGATTGTGCTGATGGGCTACAGCAATCCGATCTA
TTCCTATGGCTGGCAGCGCTTTGCCCAGGATGCCGTGCAGGCAGGTATTGATGGTCTGCTGCTGGTTGATCTGCCACCGG
AAGAGGCTGGTGAACTGCTGCCTGCAGCCAGGGCAGCCGGACTTGAGATCATCTTCCTGCTGACCCCCACCTCGGATGCG
ACCCGGATCAAGCAGGTCAGCCGCTGTGGCAGCGGTTTTCTCTATTATGTAACGGTTACCGGTGTTACCGGTGCCCGGCA
ATCCGTCTCCACCAGCCTTGAGCATGAACTGCAGACGGTACGCAACACCATCAGGCTCCCGGTTGTGGCCGGCTTCGGTA
TTTCCACCCCGGAACAGGCGGCCCAGGTGGCAGCCGCCGCCGACGGCGTCGTGGTCGGCAGTGCCATTGTCAAACTGTTT
GAACAGTACCAGGGAGAGCCGTTGCAAACCGAAGTAACCGGATTGATCAGATCATTAAAACGTGCCATTACGCCGTAA

Upstream 100 bases:

>100_bases
CTGCCACCACCTCCCAGGCTGCGCAGGTCATGAACAGTGCCGTTACCGGACTTTCCCATCAGATAGATCAGCTTGAAAAA
GAGATGTCAGGATTCAAGAT

Downstream 100 bases:

>100_bases
GATTTTTTCCCGAGAGGATATTCCATGAGCTGGTTCAAGCGTGACAAGACAGGGATAGAAAAAAGCAGCACCAAACATGT
CAAGGTGCCGGAAGGGCTCT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKSRIHNRFTQLHKQGGKALVTFITAGDPDLATTAALLPRMAEAGADIIELGIPFSDPMADGPTIQRASERALAQGVTLE
AVLAMVSQVREQVSAPIVLMGYSNPIYSYGWQRFAQDAVQAGIDGLLLVDLPPEEAGELLPAARAAGLEIIFLLTPTSDA
TRIKQVSRCGSGFLYYVTVTGVTGARQSVSTSLEHELQTVRNTIRLPVVAGFGISTPEQAAQVAAAADGVVVGSAIVKLF
EQYQGEPLQTEVTGLIRSLKRAITP

Sequences:

>Translated_265_residues
MKSRIHNRFTQLHKQGGKALVTFITAGDPDLATTAALLPRMAEAGADIIELGIPFSDPMADGPTIQRASERALAQGVTLE
AVLAMVSQVREQVSAPIVLMGYSNPIYSYGWQRFAQDAVQAGIDGLLLVDLPPEEAGELLPAARAAGLEIIFLLTPTSDA
TRIKQVSRCGSGFLYYVTVTGVTGARQSVSTSLEHELQTVRNTIRLPVVAGFGISTPEQAAQVAAAADGVVVGSAIVKLF
EQYQGEPLQTEVTGLIRSLKRAITP
>Mature_265_residues
MKSRIHNRFTQLHKQGGKALVTFITAGDPDLATTAALLPRMAEAGADIIELGIPFSDPMADGPTIQRASERALAQGVTLE
AVLAMVSQVREQVSAPIVLMGYSNPIYSYGWQRFAQDAVQAGIDGLLLVDLPPEEAGELLPAARAAGLEIIFLLTPTSDA
TRIKQVSRCGSGFLYYVTVTGVTGARQSVSTSLEHELQTVRNTIRLPVVAGFGISTPEQAAQVAAAADGVVVGSAIVKLF
EQYQGEPLQTEVTGLIRSLKRAITP

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=246, Percent_Identity=36.9918699186992, Blast_Score=164, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321412, Length=241, Percent_Identity=46.0580912863071, Blast_Score=206, Evalue=3e-54,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28112; Mature: 28112

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRIHNRFTQLHKQGGKALVTFITAGDPDLATTAALLPRMAEAGADIIELGIPFSDPMA
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPTIQRASERALAQGVTLEAVLAMVSQVREQVSAPIVLMGYSNPIYSYGWQRFAQDAVQ
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
AGIDGLLLVDLPPEEAGELLPAARAAGLEIIFLLTPTSDATRIKQVSRCGSGFLYYVTVT
HCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEEEEE
GVTGARQSVSTSLEHELQTVRNTIRLPVVAGFGISTPEQAAQVAAAADGVVVGSAIVKLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
EQYQGEPLQTEVTGLIRSLKRAITP
HHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSRIHNRFTQLHKQGGKALVTFITAGDPDLATTAALLPRMAEAGADIIELGIPFSDPMA
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPTIQRASERALAQGVTLEAVLAMVSQVREQVSAPIVLMGYSNPIYSYGWQRFAQDAVQ
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
AGIDGLLLVDLPPEEAGELLPAARAAGLEIIFLLTPTSDATRIKQVSRCGSGFLYYVTVT
HCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEEEEE
GVTGARQSVSTSLEHELQTVRNTIRLPVVAGFGISTPEQAAQVAAAADGVVVGSAIVKLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
EQYQGEPLQTEVTGLIRSLKRAITP
HHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA