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The map label for this gene is hemN [H]

Identifier: 189424293

GI number: 189424293

Start: 1274831

End: 1275973

Strand: Reverse

Name: hemN [H]

Synonym: Glov_1228

Alternate gene names: 189424293

Gene position: 1275973-1274831 (Counterclockwise)

Preceding gene: 189424295

Following gene: 189424292

Centisome position: 32.57

GC content: 58.01

Gene sequence:

>1143_bases
ATGTTTTCCCGACTGTATATCCATATCCCCTGGTGCCTCAGCAAATGCGGCTATTGTGCCTTCAGCTCCCGACCGCTTGA
ACCGCACCAACTGGAGCAGACCTGTCATCTGCTGCTGCGGGAGATGGAACTGGCAGCCACGGTCTATCCCCTCAATCAGC
CGCTCCGTTCTCTCTACTTCGGCGGCGGCACCCCTTCCCTGCTTGACCCTGAACAGGTCAGCCGCCTGATCTCCGGTTCG
CAGGCCCTGTTTGGTCATTCCAGCACCATCGAGATCACCCTGGAGGCAAATCCCGGCACGGTCAGCCTTGACTCACTGAC
CGGCTATTACCAGGCCGGAGTATCCCGGCTTTCACTGGGAGCACAATCCTTTAATGACCAGCTGCTGCAGACCCTGGGCA
GGCGGCACACTGCAGTCGAAACCTGCAACGCGTTCCAACTGGCGCAGCAGGCCGGTTTCAGCAGCATCGGCCTTGATCTG
ATCTGCGGCCTGCCGGATCAGACCATGACTGACTGGCAGCAGGATCTGGCAGCAGCGCTGGCACTCCAGCCGGACCACCT
CTCGGTCTATGGCCTGACCATTGAGGAAGAAACTCCCTTTGCCGGACGCTACCCTGTTGGATCAGATGCGCTGCCTGATC
ATGACCTGTCTGCAGGTATGCTTGAAGAGGCTGACAGCAGGCTTACTGCTGCGGGCTATGATCATTACGAGATCGCCAAC
TTTGCCCGCCCAGGCTGTCGCTCCCAGCACAACTGCGGCTACTGGCAGCGGGACGGCTACCTGGGAATCGGCCCCGGGGC
CCACTCCTTTCTGCGCCAGGAATGGGGAATCCGCTGGGGCAATCAGAGCGTTTTTGAGACCTGGGCTGCTGCCATACATG
ACAGAAAACTTGCAGCAACGGAACAGCAGGAACTGACCCGCGAAGATGCCCTGTCAGAATATATCTTTCTGGGTCTGCGT
ATGGCTGACGGCATCAGTCTTAACGGTTTTGCAGAGGAATTTGGAGAACGGCTTGAGCACCGTTTTTCAGAAGCGATCCA
TCAGCTGCAACAGGCCGGATTACTGACCTGCAGCCAGGACCGGCTCTGCCTGACCAAACAGGGGATGCTGCTTTCAAATC
AGGTCTTCGTGCGCTTTCTCTAA

Upstream 100 bases:

>100_bases
CGCACGGCGCGGAGCGACCGAGACATACCACAGCAGGTAGACAAGGAAGCGAGCACCGCGCAACGCAGCAGACAGCCACC
GCAGTAGTTTTTTCTGCCTG

Downstream 100 bases:

>100_bases
ACTATGCTATAAGATCTTCATGATCCCCAATCTCCGCACCACATACCGGAAATGGCGACCATGAAGAGCATTCCGGCCCT
CTTCCTGTTCCTGCTGTTTT

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MFSRLYIHIPWCLSKCGYCAFSSRPLEPHQLEQTCHLLLREMELAATVYPLNQPLRSLYFGGGTPSLLDPEQVSRLISGS
QALFGHSSTIEITLEANPGTVSLDSLTGYYQAGVSRLSLGAQSFNDQLLQTLGRRHTAVETCNAFQLAQQAGFSSIGLDL
ICGLPDQTMTDWQQDLAAALALQPDHLSVYGLTIEEETPFAGRYPVGSDALPDHDLSAGMLEEADSRLTAAGYDHYEIAN
FARPGCRSQHNCGYWQRDGYLGIGPGAHSFLRQEWGIRWGNQSVFETWAAAIHDRKLAATEQQELTREDALSEYIFLGLR
MADGISLNGFAEEFGERLEHRFSEAIHQLQQAGLLTCSQDRLCLTKQGMLLSNQVFVRFL

Sequences:

>Translated_380_residues
MFSRLYIHIPWCLSKCGYCAFSSRPLEPHQLEQTCHLLLREMELAATVYPLNQPLRSLYFGGGTPSLLDPEQVSRLISGS
QALFGHSSTIEITLEANPGTVSLDSLTGYYQAGVSRLSLGAQSFNDQLLQTLGRRHTAVETCNAFQLAQQAGFSSIGLDL
ICGLPDQTMTDWQQDLAAALALQPDHLSVYGLTIEEETPFAGRYPVGSDALPDHDLSAGMLEEADSRLTAAGYDHYEIAN
FARPGCRSQHNCGYWQRDGYLGIGPGAHSFLRQEWGIRWGNQSVFETWAAAIHDRKLAATEQQELTREDALSEYIFLGLR
MADGISLNGFAEEFGERLEHRFSEAIHQLQQAGLLTCSQDRLCLTKQGMLLSNQVFVRFL
>Mature_380_residues
MFSRLYIHIPWCLSKCGYCAFSSRPLEPHQLEQTCHLLLREMELAATVYPLNQPLRSLYFGGGTPSLLDPEQVSRLISGS
QALFGHSSTIEITLEANPGTVSLDSLTGYYQAGVSRLSLGAQSFNDQLLQTLGRRHTAVETCNAFQLAQQAGFSSIGLDL
ICGLPDQTMTDWQQDLAAALALQPDHLSVYGLTIEEETPFAGRYPVGSDALPDHDLSAGMLEEADSRLTAAGYDHYEIAN
FARPGCRSQHNCGYWQRDGYLGIGPGAHSFLRQEWGIRWGNQSVFETWAAAIHDRKLAATEQQELTREDALSEYIFLGLR
MADGISLNGFAEEFGERLEHRFSEAIHQLQQAGLLTCSQDRLCLTKQGMLLSNQVFVRFL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=266, Percent_Identity=37.593984962406, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1789325, Length=389, Percent_Identity=36.2467866323907, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI87082341, Length=391, Percent_Identity=25.8312020460358, Blast_Score=121, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42172; Mature: 42172

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRLYIHIPWCLSKCGYCAFSSRPLEPHQLEQTCHLLLREMELAATVYPLNQPLRSLYF
CCCEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
GGGTPSLLDPEQVSRLISGSQALFGHSSTIEITLEANPGTVSLDSLTGYYQAGVSRLSLG
CCCCCCCCCHHHHHHHHCCCHHEECCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHH
AQSFNDQLLQTLGRRHTAVETCNAFQLAQQAGFSSIGLDLICGLPDQTMTDWQQDLAAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHHHHHH
ALQPDHLSVYGLTIEEETPFAGRYPVGSDALPDHDLSAGMLEEADSRLTAAGYDHYEIAN
HCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEECCCCCHHHHH
FARPGCRSQHNCGYWQRDGYLGIGPGAHSFLRQEWGIRWGNQSVFETWAAAIHDRKLAAT
HCCCCCCCCCCCCCEECCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EQQELTREDALSEYIFLGLRMADGISLNGFAEEFGERLEHRFSEAIHQLQQAGLLTCSQD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
RLCLTKQGMLLSNQVFVRFL
CEEEECCCCEEECCEEEEEC
>Mature Secondary Structure
MFSRLYIHIPWCLSKCGYCAFSSRPLEPHQLEQTCHLLLREMELAATVYPLNQPLRSLYF
CCCEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
GGGTPSLLDPEQVSRLISGSQALFGHSSTIEITLEANPGTVSLDSLTGYYQAGVSRLSLG
CCCCCCCCCHHHHHHHHCCCHHEECCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHH
AQSFNDQLLQTLGRRHTAVETCNAFQLAQQAGFSSIGLDLICGLPDQTMTDWQQDLAAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHHHHHH
ALQPDHLSVYGLTIEEETPFAGRYPVGSDALPDHDLSAGMLEEADSRLTAAGYDHYEIAN
HCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEECCCCCHHHHH
FARPGCRSQHNCGYWQRDGYLGIGPGAHSFLRQEWGIRWGNQSVFETWAAAIHDRKLAAT
HCCCCCCCCCCCCCEECCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EQQELTREDALSEYIFLGLRMADGISLNGFAEEFGERLEHRFSEAIHQLQQAGLLTCSQD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
RLCLTKQGMLLSNQVFVRFL
CEEEECCCCEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]