Click here to switch to the map view.

The map label for this gene is apt

Identifier: 189424150

GI number: 189424150

Start: 1132607

End: 1133122

Strand: Reverse

Name: apt

Synonym: Glov_1084

Alternate gene names: 189424150

Gene position: 1133122-1132607 (Counterclockwise)

Preceding gene: 189424151

Following gene: 189424147

Centisome position: 28.92

GC content: 53.1

Gene sequence:

>516_bases
ATGGAAGATCTTAAACTTACCATTCGCGACATCCCTGATTTCCCCAAAAAGGGGATCATTTTCAAAGACATCACCACCCT
GTTGCAAGATGCGAAGTCCTTTACCCGGATGATTGACATGATCGCCAATCGCTACATCGGCCAAAGGATCGACAAGGTGG
TGGGTGTTGAGGCGCGGGGATTCCTGATTGGCGCAGCCTTGGCGTACCGCCTGGGTGCCGGGGTCGTACTGGTCCGTAAA
CCGGGCAAACTGCCTTCTGAAACCTTCAGCAAGACCTACGACCTGGAATATGGTACCGACACCCTTGAAATCCACAAAGA
CGCCATTAAACCGGGTGAAAAGATTCTGATAGCCGACGACCTGCTGGCAACCGGCGGCACCATGGCAGCCGTGGTGGATA
TGGTCACCAACATGCAGGGCGAGATCGTGGAGTGCTGCTTCATGACTGAACTGACCTTCCTGGACGGCCGCAAGAAACTG
CCTGAAGGAAAGGTTTACTCTCTGATGCAATTCTGA

Upstream 100 bases:

>100_bases
GGCGTTACCCGTGAAAGGATTCGCCAGATCGAGGCAAAATCACTCGAAAAACTAAAGGCCCTGGCCAAATCATCGAAATA
GAAACAAGGAGATTACTCCC

Downstream 100 bases:

>100_bases
TAAAAGAAAAACCCCTGTCCCCGTAGCTCAGCAGGATAGAGCGACTCCCTCCTAAGGAGTAGGCCGGACGTTCGAATCGT
CTCGGGGACGCCAAATATCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARGFLIGAALAYRLGAGVVLVRK
PGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADDLLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKL
PEGKVYSLMQF

Sequences:

>Translated_171_residues
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARGFLIGAALAYRLGAGVVLVRK
PGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADDLLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKL
PEGKVYSLMQF
>Mature_171_residues
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARGFLIGAALAYRLGAGVVLVRK
PGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADDLLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKL
PEGKVYSLMQF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=168, Percent_Identity=47.6190476190476, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=53.757225433526, Blast_Score=185, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=166, Percent_Identity=42.7710843373494, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=41.6184971098266, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=31.2138728323699, Blast_Score=84, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=41.6184971098266, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GEOLS (B3E683)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951327.1
- ProteinModelPortal:   B3E683
- SMR:   B3E683
- GeneID:   6368172
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1084
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18999; Mature: 18999

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARG
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FLIGAALAYRLGAGVVLVRKPGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADD
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHEECCCCCCCHHHHHHHHCCCCCEEEEECH
LLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKLPEGKVYSLMQF
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MEDLKLTIRDIPDFPKKGIIFKDITTLLQDAKSFTRMIDMIANRYIGQRIDKVVGVEARG
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FLIGAALAYRLGAGVVLVRKPGKLPSETFSKTYDLEYGTDTLEIHKDAIKPGEKILIADD
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHEECCCCCCCHHHHHHHHCCCCCEEEEECH
LLATGGTMAAVVDMVTNMQGEIVECCFMTELTFLDGRKKLPEGKVYSLMQF
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA