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The map label for this gene is hisH [H]

Identifier: 189424086

GI number: 189424086

Start: 1059367

End: 1059990

Strand: Reverse

Name: hisH [H]

Synonym: Glov_1020

Alternate gene names: 189424086

Gene position: 1059990-1059367 (Counterclockwise)

Preceding gene: 189424087

Following gene: 189424085

Centisome position: 27.06

GC content: 56.41

Gene sequence:

>624_bases
ATGATCGCAATCATTGACTACGGCATGGGCAACCTGCGCTCGGTTCAAAAAGGCTTTGAGCGGATAGGTTTTGCGGCGGA
AGTAACCGCTGATCCGGCACGCATCCTTGCAGCAGAAAAAATCGTACTGCCGGGGGTAGGCGCCTTCCGGGATTGTATCC
ACAATCTGGAGCAGGGTAGGTTTGTTGAGCCGATCCTGCAGGTGATTGCCGAAGGGCGGCCTTTTCTGGGGATCTGCCTC
GGGCTGCAGCTGCTTTTTAGCGAAAGCGAAGAGTTCGGCCTGCACAAGGGGCTGGGAGTCATCCCCGGACGGGTGGTCCG
TTTCCCGGAGGGAATGAAGGAACAGGGGGAAAAGCTGCCGGTACCTCACATGGGCTGGAATCAGATCACCCTGAAGGCAG
AGACACCGTTGTTTAACGGCATTAGCGACGGCAGTAACGTCTATTTCGTACACTCCTACTACGTCAGGCCCGATGACCCG
TCTGTCGTAGCAGCCACCTGCAGCTACGGCCTGGAATTCTGCGCCGCCATCCGCAAGGACAATGTCATGGCCACCCAGTT
TCACCCTGAAAAATCGCAGGGAATCGGCCTGCAGATGCTGAAAAACTTTGCCGAACTGCACTGA

Upstream 100 bases:

>100_bases
TCTCGCAGGACGTGATCACCTTCCTGCAGAAGTGGCTGATCGACCACATCAAGGGGCAGGACAAGAAATACGGTCCACAC
CTGACCAAGAATGGTATCAA

Downstream 100 bases:

>100_bases
TCTACCAAGAACACGAAGTATCACTAAGAAAACTACAAAAAGCAGTCAACTTGATTTTAGCTTTACGCCTTACTTGGTGT
ACCTTCGTGTCCTTCGTGGA

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MIAIIDYGMGNLRSVQKGFERIGFAAEVTADPARILAAEKIVLPGVGAFRDCIHNLEQGRFVEPILQVIAEGRPFLGICL
GLQLLFSESEEFGLHKGLGVIPGRVVRFPEGMKEQGEKLPVPHMGWNQITLKAETPLFNGISDGSNVYFVHSYYVRPDDP
SVVAATCSYGLEFCAAIRKDNVMATQFHPEKSQGIGLQMLKNFAELH

Sequences:

>Translated_207_residues
MIAIIDYGMGNLRSVQKGFERIGFAAEVTADPARILAAEKIVLPGVGAFRDCIHNLEQGRFVEPILQVIAEGRPFLGICL
GLQLLFSESEEFGLHKGLGVIPGRVVRFPEGMKEQGEKLPVPHMGWNQITLKAETPLFNGISDGSNVYFVHSYYVRPDDP
SVVAATCSYGLEFCAAIRKDNVMATQFHPEKSQGIGLQMLKNFAELH
>Mature_207_residues
MIAIIDYGMGNLRSVQKGFERIGFAAEVTADPARILAAEKIVLPGVGAFRDCIHNLEQGRFVEPILQVIAEGRPFLGICL
GLQLLFSESEEFGLHKGLGVIPGRVVRFPEGMKEQGEKLPVPHMGWNQITLKAETPLFNGISDGSNVYFVHSYYVRPDDP
SVVAATCSYGLEFCAAIRKDNVMATQFHPEKSQGIGLQMLKNFAELH

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=205, Percent_Identity=42.9268292682927, Blast_Score=148, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319725, Length=214, Percent_Identity=35.5140186915888, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22776; Mature: 22776

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIDYGMGNLRSVQKGFERIGFAAEVTADPARILAAEKIVLPGVGAFRDCIHNLEQGR
CEEEEECCCCHHHHHHHHHHHHCCEEECCCCHHHHHHHHHEECCCCHHHHHHHHHHHCCC
FVEPILQVIAEGRPFLGICLGLQLLFSESEEFGLHKGLGVIPGRVVRFPEGMKEQGEKLP
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEECCCCHHHCCCCCC
VPHMGWNQITLKAETPLFNGISDGSNVYFVHSYYVRPDDPSVVAATCSYGLEFCAAIRKD
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCC
NVMATQFHPEKSQGIGLQMLKNFAELH
CEEEEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MIAIIDYGMGNLRSVQKGFERIGFAAEVTADPARILAAEKIVLPGVGAFRDCIHNLEQGR
CEEEEECCCCHHHHHHHHHHHHCCEEECCCCHHHHHHHHHEECCCCHHHHHHHHHHHCCC
FVEPILQVIAEGRPFLGICLGLQLLFSESEEFGLHKGLGVIPGRVVRFPEGMKEQGEKLP
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEECCCCHHHCCCCCC
VPHMGWNQITLKAETPLFNGISDGSNVYFVHSYYVRPDDPSVVAATCSYGLEFCAAIRKD
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCC
NVMATQFHPEKSQGIGLQMLKNFAELH
CEEEEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA