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The map label for this gene is mutL

Identifier: 189424059

GI number: 189424059

Start: 1031120

End: 1032889

Strand: Reverse

Name: mutL

Synonym: Glov_0993

Alternate gene names: 189424059

Gene position: 1032889-1031120 (Counterclockwise)

Preceding gene: 189424060

Following gene: 189424058

Centisome position: 26.36

GC content: 62.26

Gene sequence:

>1770_bases
GTGGCACCGCACGTACGTATCCTTTCTGAATCCCTTGCCAACAAGATAGCCGCCGGAGAGGTGGTTGAACGCCCTGCCTC
GGTGGTCAAGGAGCTGATTGAAAATGCTCTGGATGCCGGTGCGACCGACATCCGGCTGGAAATCAGTGCCGGAGGACGAC
GCCTGATCAGGGTCAGCGACAACGGCCACGGCATGTCACGCGAGGACGCCTTGCTGGCATTGGAGCGTCACGCCACCAGC
AAAATCAGGTCGGACCAGGATCTTGAAACCATTCTAACCCTGGGTTTCCGGGGTGAAGCGCTGCCCTCCATCGCCTCGGT
TTCCCGCCTGCGTCTGAAGAGCCGTGAAGCCGGCAGCATAGAAGGGACCGAGATTACCGCTGAAGGCGGGACGGTTCGCT
CGGTTACAGCCTGCGGCATGGCCGTGGGCACTGACCTGACCGTGGAGCAGCTCTTCTTCAACACCCCGGCCCGCTTGAAA
TTCCTGCGCAGCGCCGAAACCGAGGCGGCCCATGTGGGGGATCTGATGGTCCGCATGGCTATCTCCCGTCCCGATGTCTC
CTTCAGTTATTATCATGACGGACGCGAGCTGCTGCGGGTTGTTCCCGGCGACCTGCGCCAGCGTCTGCTGAAGCTGGCGG
CACGGGATGCCACCCTGTTCCCGGTGGACGGAGAGACGGCGGCAGCACGCATCAGCGGCTATCTGGCGCCTCCTGCAGCA
GCCCGCTCAACCACCTCGGCCATGTTCACCTACATCAACGGCCGTTTTGTCAGGGACAAGGTCATCCAGCATGCCATCAT
GCAGGCCTTCCGCCCGATCCTTGAAAAAGGGCGTTACCCCTTGGTTGCGCTGTTTATCGAGCTGCCTGCCGGTGAGGTGG
ATGTCAATGTCCACCCCACCAAGCATGAGGTCCGCTTCCGGCGCCAGGCCCAGGTCCACGACACCATCCAGGGGGTGTTG
GAGGAGGTCTTGCGCGACTCCCCCTGGCTGCAACGCCGTGAAGCTCCACAGCGGCCCGAGCCGGCACGGCCGTATACCAC
TCCCCCGCCATCCTCACACCGGGAAGGGGTGCAGCATGCCCTTGACCGCTTCATGGCTGCAACGCCGGTTGCGCCCCCCC
GGATATACGAACAGCCTGAGCCCTATCGCCCGCCAGAACCGCCGGCCGCCTCCGAACCGACCTCCGGCTATTTTTCCGGC
CTGAGTGTCATCGGTCAGTTCCGCGCCGCCTATATCCTCTGCCAGGCAGAGGATCGCCTGGTGATCATTGACCAGCACGC
GGCCTATGAACGGGTCAGATTTGAACAACTGAAGGCCGGATTTGCAACCGGCGGCATAGAATCCCAACGGCTGCTGCTGC
CGGACACCCTGGAACTGTCCTTTAGCGAAGCTGACACGGTCCGTCGCTACCTGAACATTCTGGAACCGCTGGGCTTCGAG
CTGGAGGAGTTTGGCGGCCAGACCTGGCGGATCAATGCCGTACCCCGGATTGTGGCAGAACAGGATCATTGCCGCCTGCT
GCGCGACCTGCTGGCAGAACTGGCTGAACAGGGCAGTAATGCACACTTTGACCAGCTCAGGGATGAACTGCTGGCCCGGG
TGGCCTGCCACAGCGTGGTACGCGGCAGCCATCCTCTGGAGCGCCGTCAGATGGAGGAACTGCTGAGGGCGATGGACCGT
ACCGATTTCTCGGCACACTGTCCCCATGGCCGGCCGGTCTCCCATGAGATCACCCTGCGAGAACTGGAAAAGTTCTTCAA
CCGGCCATGA

Upstream 100 bases:

>100_bases
GGACGGTTCTGAAAAGAAATAGTCCGTACCGGACAGGCGGCTACTTTTTCCGAGCGGGGCTTCCCCGCTCTTTTTCGCTG
GTAGATGGAGTGGCATTTCT

Downstream 100 bases:

>100_bases
AGCCCCGTGTACTGGTCATTGCCGGCCCCACGGCATCGGGTAAATCAGCGTTGGCCCTTGATCTGGCTGTGGCGTTGGAC
GGAGAGATCATCTGCGCCGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MAPHVRILSESLANKIAAGEVVERPASVVKELIENALDAGATDIRLEISAGGRRLIRVSDNGHGMSREDALLALERHATS
KIRSDQDLETILTLGFRGEALPSIASVSRLRLKSREAGSIEGTEITAEGGTVRSVTACGMAVGTDLTVEQLFFNTPARLK
FLRSAETEAAHVGDLMVRMAISRPDVSFSYYHDGRELLRVVPGDLRQRLLKLAARDATLFPVDGETAAARISGYLAPPAA
ARSTTSAMFTYINGRFVRDKVIQHAIMQAFRPILEKGRYPLVALFIELPAGEVDVNVHPTKHEVRFRRQAQVHDTIQGVL
EEVLRDSPWLQRREAPQRPEPARPYTTPPPSSHREGVQHALDRFMAATPVAPPRIYEQPEPYRPPEPPAASEPTSGYFSG
LSVIGQFRAAYILCQAEDRLVIIDQHAAYERVRFEQLKAGFATGGIESQRLLLPDTLELSFSEADTVRRYLNILEPLGFE
LEEFGGQTWRINAVPRIVAEQDHCRLLRDLLAELAEQGSNAHFDQLRDELLARVACHSVVRGSHPLERRQMEELLRAMDR
TDFSAHCPHGRPVSHEITLRELEKFFNRP

Sequences:

>Translated_589_residues
MAPHVRILSESLANKIAAGEVVERPASVVKELIENALDAGATDIRLEISAGGRRLIRVSDNGHGMSREDALLALERHATS
KIRSDQDLETILTLGFRGEALPSIASVSRLRLKSREAGSIEGTEITAEGGTVRSVTACGMAVGTDLTVEQLFFNTPARLK
FLRSAETEAAHVGDLMVRMAISRPDVSFSYYHDGRELLRVVPGDLRQRLLKLAARDATLFPVDGETAAARISGYLAPPAA
ARSTTSAMFTYINGRFVRDKVIQHAIMQAFRPILEKGRYPLVALFIELPAGEVDVNVHPTKHEVRFRRQAQVHDTIQGVL
EEVLRDSPWLQRREAPQRPEPARPYTTPPPSSHREGVQHALDRFMAATPVAPPRIYEQPEPYRPPEPPAASEPTSGYFSG
LSVIGQFRAAYILCQAEDRLVIIDQHAAYERVRFEQLKAGFATGGIESQRLLLPDTLELSFSEADTVRRYLNILEPLGFE
LEEFGGQTWRINAVPRIVAEQDHCRLLRDLLAELAEQGSNAHFDQLRDELLARVACHSVVRGSHPLERRQMEELLRAMDR
TDFSAHCPHGRPVSHEITLRELEKFFNRP
>Mature_588_residues
APHVRILSESLANKIAAGEVVERPASVVKELIENALDAGATDIRLEISAGGRRLIRVSDNGHGMSREDALLALERHATSK
IRSDQDLETILTLGFRGEALPSIASVSRLRLKSREAGSIEGTEITAEGGTVRSVTACGMAVGTDLTVEQLFFNTPARLKF
LRSAETEAAHVGDLMVRMAISRPDVSFSYYHDGRELLRVVPGDLRQRLLKLAARDATLFPVDGETAAARISGYLAPPAAA
RSTTSAMFTYINGRFVRDKVIQHAIMQAFRPILEKGRYPLVALFIELPAGEVDVNVHPTKHEVRFRRQAQVHDTIQGVLE
EVLRDSPWLQRREAPQRPEPARPYTTPPPSSHREGVQHALDRFMAATPVAPPRIYEQPEPYRPPEPPAASEPTSGYFSGL
SVIGQFRAAYILCQAEDRLVIIDQHAAYERVRFEQLKAGFATGGIESQRLLLPDTLELSFSEADTVRRYLNILEPLGFEL
EEFGGQTWRINAVPRIVAEQDHCRLLRDLLAELAEQGSNAHFDQLRDELLARVACHSVVRGSHPLERRQMEELLRAMDRT
DFSAHCPHGRPVSHEITLRELEKFFNRP

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=33.7349397590361, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=32.0121951219512, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=32.0121951219512, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI189458896, Length=323, Percent_Identity=31.2693498452012, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505913, Length=338, Percent_Identity=28.1065088757396, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128478, Length=338, Percent_Identity=28.1065088757396, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI263191589, Length=238, Percent_Identity=27.3109243697479, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=26.8939393939394, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=26.8939393939394, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790612, Length=561, Percent_Identity=37.0766488413547, Blast_Score=280, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71991825, Length=353, Percent_Identity=33.7110481586402, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=340, Percent_Identity=26.4705882352941, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=33.0383480825959, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=371, Percent_Identity=25.6064690026954, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=177, Percent_Identity=28.8135593220339, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136968, Length=333, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136970, Length=178, Percent_Identity=30.8988764044944, Blast_Score=97, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_GEOLS (B3E5Z2)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951236.1
- ProteinModelPortal:   B3E5Z2
- GeneID:   6367308
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_0993
- HOGENOM:   HBG520262
- OMA:   KIFFAPP
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 65682; Mature: 65550

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPHVRILSESLANKIAAGEVVERPASVVKELIENALDAGATDIRLEISAGGRRLIRVSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECC
NGHGMSREDALLALERHATSKIRSDQDLETILTLGFRGEALPSIASVSRLRLKSREAGSI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
EGTEITAEGGTVRSVTACGMAVGTDLTVEQLFFNTPARLKFLRSAETEAAHVGDLMVRMA
CCCEEEECCCCEEHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHH
ISRPDVSFSYYHDGRELLRVVPGDLRQRLLKLAARDATLFPVDGETAAARISGYLAPPAA
HCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCHH
ARSTTSAMFTYINGRFVRDKVIQHAIMQAFRPILEKGRYPLVALFIELPAGEVDVNVHPT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
KHEVRFRRQAQVHDTIQGVLEEVLRDSPWLQRREAPQRPEPARPYTTPPPSSHREGVQHA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LDRFMAATPVAPPRIYEQPEPYRPPEPPAASEPTSGYFSGLSVIGQFRAAYILCQAEDRL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCE
VIIDQHAAYERVRFEQLKAGFATGGIESQRLLLPDTLELSFSEADTVRRYLNILEPLGFE
EEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEEFGGQTWRINAVPRIVAEQDHCRLLRDLLAELAEQGSNAHFDQLRDELLARVACHSVV
HHHHCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RGSHPLERRQMEELLRAMDRTDFSAHCPHGRPVSHEITLRELEKFFNRP
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
APHVRILSESLANKIAAGEVVERPASVVKELIENALDAGATDIRLEISAGGRRLIRVSD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECC
NGHGMSREDALLALERHATSKIRSDQDLETILTLGFRGEALPSIASVSRLRLKSREAGSI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
EGTEITAEGGTVRSVTACGMAVGTDLTVEQLFFNTPARLKFLRSAETEAAHVGDLMVRMA
CCCEEEECCCCEEHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHH
ISRPDVSFSYYHDGRELLRVVPGDLRQRLLKLAARDATLFPVDGETAAARISGYLAPPAA
HCCCCCEEEEECCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCHH
ARSTTSAMFTYINGRFVRDKVIQHAIMQAFRPILEKGRYPLVALFIELPAGEVDVNVHPT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
KHEVRFRRQAQVHDTIQGVLEEVLRDSPWLQRREAPQRPEPARPYTTPPPSSHREGVQHA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LDRFMAATPVAPPRIYEQPEPYRPPEPPAASEPTSGYFSGLSVIGQFRAAYILCQAEDRL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCE
VIIDQHAAYERVRFEQLKAGFATGGIESQRLLLPDTLELSFSEADTVRRYLNILEPLGFE
EEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEEFGGQTWRINAVPRIVAEQDHCRLLRDLLAELAEQGSNAHFDQLRDELLARVACHSVV
HHHHCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RGSHPLERRQMEELLRAMDRTDFSAHCPHGRPVSHEITLRELEKFFNRP
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA