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The map label for this gene is pcaK [H]

Identifier: 189424003

GI number: 189424003

Start: 970515

End: 971861

Strand: Reverse

Name: pcaK [H]

Synonym: Glov_0937

Alternate gene names: 189424003

Gene position: 971861-970515 (Counterclockwise)

Preceding gene: 189424004

Following gene: 189424002

Centisome position: 24.81

GC content: 57.09

Gene sequence:

>1347_bases
GTGAGCAGGTCTGTGAACGTTAATGAAGTATTCGATAATATTCCTTTTTCACCTTACCAAACAGCAGTTTGCCTACTCTG
TTTCTGTATCGTCTTTCTTGACGGCTTTGACCTGACGGTCATCGGAGTGGCACTACCCAAGATCGCCGAGCATCTGAACG
CCAAGCCGAGCGAACTGGGGTTGGCATTAAGTGCCGGACAGCTGGGGCCCATGATCGGCGCGGTACTGCTGGGCATGCTG
GCTGACCGTGTCGGACGCAAGAAGACCATGTTCTGCTCAGCCATTGTCTTTGGTTTTTTCACCTACATGACCACCCATAT
CACCAGTGTCGAAGAACTGGCAGCCTACCGTTTTCTGGCCGGCCTCGGCATGGGTGGCGCCATCCCCAACGCCCTGGCCT
TCGGCAGTGAATATGCTCCAGCCAGAATCCGCACCTCACTTTCCCTCTATATGTGGGCCGGCATGCCCTGCGGTGCCATG
ATCGCAGGATTTGCCGCTTCCTGGCTGCTGCCCCACTACGGCTGGCAATCGGTCTTCATCGTGGGGGGGATCGCGCCGGT
GGCGATTGCGCTGCTGATCCTGTTGCTGTTGCCTGATTCCCTGCACCACCTGGTCAGGACCGGAACAGCCAAATCCATTG
CCAAGGCCCGTGAAATTCTGGCACGGATTGACAGATCATCACCGCTCTCCGCAGATATCGAACTGACGGTCACCAGCCAG
ACCAAGGAAAAAGGCGGTTCCCTCAAGTCACTGTTTACCGACCACCGCCTGCTGACGACCATACTGCTCTGGATCCTGTT
CTACATGAGCTTCTATCTGCTCTGGATCCTCTTTTCCTGGGTACCCACCCTGCTCAAGAAGAGCGGTGCGTCGGTCCAGC
AGTACAGCATCGGCTTTGCCTTCATTCACCTTGGCTCTGTTGTGGCTATACTCTGCATCGGCCGCTGTATGGACAAATAC
AACAAGCTGAATGTCGTGAAATACGTCTTCCTGGCCGCCTTCTTTGCCATGCTGGCGTTCGGCTACTTCTCTTCAGGCTA
CCCCTTTGCCGTGGTCATCGTGGTTTCCGTACTGGCCGGGCTTTTTGTGAACGGCGGCAACTCCGCACTGATGGGGCTGG
CATCGGCGGTCTACCCGGCAGAGATCAGGGCCACCGGCATCGGCTGGGCCTACGGCATCGGCAAGATCGGCTCGTTCCTC
GCACCGGCCGTTGGCGGATTTTATCTGGCCCGCAACTGGAGCGTGTTTGACATCTGCGCCGTCAACGGCAGCAGCGCATT
GATCATTGCCGTCGTCGTCGTCATTCTGCAGCGGCATATGCGTTCAACCGCCCGTGGCGAGGTGTAA

Upstream 100 bases:

>100_bases
CAAGACCGTATCGAAAGATTGCCATGCAGCTTTTCTCCAGCTGAGCCTCATCAGTGCAAAGAGGCTAATGAACCGGAATA
CGATTTGAGGGAGGTCACAC

Downstream 100 bases:

>100_bases
GAACCGCTTTGCCGGTTGATTCAAAAACTGAAGCCTACATCCACACAGACAAACCAACGCACAGGGGCCGGTACTCACCG
GCCCCTGTTTTTTGGGCTGG

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSRSVNVNEVFDNIPFSPYQTAVCLLCFCIVFLDGFDLTVIGVALPKIAEHLNAKPSELGLALSAGQLGPMIGAVLLGML
ADRVGRKKTMFCSAIVFGFFTYMTTHITSVEELAAYRFLAGLGMGGAIPNALAFGSEYAPARIRTSLSLYMWAGMPCGAM
IAGFAASWLLPHYGWQSVFIVGGIAPVAIALLILLLLPDSLHHLVRTGTAKSIAKAREILARIDRSSPLSADIELTVTSQ
TKEKGGSLKSLFTDHRLLTTILLWILFYMSFYLLWILFSWVPTLLKKSGASVQQYSIGFAFIHLGSVVAILCIGRCMDKY
NKLNVVKYVFLAAFFAMLAFGYFSSGYPFAVVIVVSVLAGLFVNGGNSALMGLASAVYPAEIRATGIGWAYGIGKIGSFL
APAVGGFYLARNWSVFDICAVNGSSALIIAVVVVILQRHMRSTARGEV

Sequences:

>Translated_448_residues
MSRSVNVNEVFDNIPFSPYQTAVCLLCFCIVFLDGFDLTVIGVALPKIAEHLNAKPSELGLALSAGQLGPMIGAVLLGML
ADRVGRKKTMFCSAIVFGFFTYMTTHITSVEELAAYRFLAGLGMGGAIPNALAFGSEYAPARIRTSLSLYMWAGMPCGAM
IAGFAASWLLPHYGWQSVFIVGGIAPVAIALLILLLLPDSLHHLVRTGTAKSIAKAREILARIDRSSPLSADIELTVTSQ
TKEKGGSLKSLFTDHRLLTTILLWILFYMSFYLLWILFSWVPTLLKKSGASVQQYSIGFAFIHLGSVVAILCIGRCMDKY
NKLNVVKYVFLAAFFAMLAFGYFSSGYPFAVVIVVSVLAGLFVNGGNSALMGLASAVYPAEIRATGIGWAYGIGKIGSFL
APAVGGFYLARNWSVFDICAVNGSSALIIAVVVVILQRHMRSTARGEV
>Mature_447_residues
SRSVNVNEVFDNIPFSPYQTAVCLLCFCIVFLDGFDLTVIGVALPKIAEHLNAKPSELGLALSAGQLGPMIGAVLLGMLA
DRVGRKKTMFCSAIVFGFFTYMTTHITSVEELAAYRFLAGLGMGGAIPNALAFGSEYAPARIRTSLSLYMWAGMPCGAMI
AGFAASWLLPHYGWQSVFIVGGIAPVAIALLILLLLPDSLHHLVRTGTAKSIAKAREILARIDRSSPLSADIELTVTSQT
KEKGGSLKSLFTDHRLLTTILLWILFYMSFYLLWILFSWVPTLLKKSGASVQQYSIGFAFIHLGSVVAILCIGRCMDKYN
KLNVVKYVFLAAFFAMLAFGYFSSGYPFAVVIVVSVLAGLFVNGGNSALMGLASAVYPAEIRATGIGWAYGIGKIGSFLA
PAVGGFYLARNWSVFDICAVNGSSALIIAVVVVILQRHMRSTARGEV

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=462, Percent_Identity=21.4285714285714, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7662270, Length=190, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI213021148, Length=432, Percent_Identity=22.6851851851852, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI73695465, Length=153, Percent_Identity=28.7581699346405, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081723, Length=417, Percent_Identity=29.7362110311751, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1786229, Length=402, Percent_Identity=25.8706467661692, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082231, Length=444, Percent_Identity=21.3963963963964, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082159, Length=397, Percent_Identity=22.4181360201511, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082404, Length=387, Percent_Identity=23.2558139534884, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789207, Length=317, Percent_Identity=26.4984227129338, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788068, Length=466, Percent_Identity=22.7467811158798, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=428, Percent_Identity=20.5607476635514, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48214; Mature: 48082

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVNVNEVFDNIPFSPYQTAVCLLCFCIVFLDGFDLTVIGVALPKIAEHLNAKPSELG
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHC
LALSAGQLGPMIGAVLLGMLADRVGRKKTMFCSAIVFGFFTYMTTHITSVEELAAYRFLA
EEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGMGGAIPNALAFGSEYAPARIRTSLSLYMWAGMPCGAMIAGFAASWLLPHYGWQSVFI
HCCCCCCCCHHHHCCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
VGGIAPVAIALLILLLLPDSLHHLVRTGTAKSIAKAREILARIDRSSPLSADIELTVTSQ
ECCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
TKEKGGSLKSLFTDHRLLTTILLWILFYMSFYLLWILFSWVPTLLKKSGASVQQYSIGFA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FIHLGSVVAILCIGRCMDKYNKLNVVKYVFLAAFFAMLAFGYFSSGYPFAVVIVVSVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LFVNGGNSALMGLASAVYPAEIRATGIGWAYGIGKIGSFLAPAVGGFYLARNWSVFDICA
HHCCCCCHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEE
VNGSSALIIAVVVVILQRHMRSTARGEV
ECCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRSVNVNEVFDNIPFSPYQTAVCLLCFCIVFLDGFDLTVIGVALPKIAEHLNAKPSELG
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHC
LALSAGQLGPMIGAVLLGMLADRVGRKKTMFCSAIVFGFFTYMTTHITSVEELAAYRFLA
EEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGMGGAIPNALAFGSEYAPARIRTSLSLYMWAGMPCGAMIAGFAASWLLPHYGWQSVFI
HCCCCCCCCHHHHCCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
VGGIAPVAIALLILLLLPDSLHHLVRTGTAKSIAKAREILARIDRSSPLSADIELTVTSQ
ECCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
TKEKGGSLKSLFTDHRLLTTILLWILFYMSFYLLWILFSWVPTLLKKSGASVQQYSIGFA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FIHLGSVVAILCIGRCMDKYNKLNVVKYVFLAAFFAMLAFGYFSSGYPFAVVIVVSVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LFVNGGNSALMGLASAVYPAEIRATGIGWAYGIGKIGSFLAPAVGGFYLARNWSVFDICA
HHCCCCCHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEE
VNGSSALIIAVVVVILQRHMRSTARGEV
ECCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]