Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 189423959

GI number: 189423959

Start: 923130

End: 924350

Strand: Reverse

Name: moeA [H]

Synonym: Glov_0893

Alternate gene names: 189423959

Gene position: 924350-923130 (Counterclockwise)

Preceding gene: 189423964

Following gene: 189423958

Centisome position: 23.59

GC content: 58.72

Gene sequence:

>1221_bases
ATGATCAGCATCAATGCTGCACAAGAGATTGTCCTTAAGCATACGACACAGATCGATAGTGAGTCCGTTCCCCTCCTGGA
GGCGATCGGCAGAATCATCGCCGTTGATATGCGGGCCCCCCATGATCTCCCGCTGTCAAACAACTCTGCCATGGATGGGT
ATGCGCTGGCCCTGCGGCCGGGGCAGGAACAGTGGAACGTTGTGGATTTTATTCCTGCCGGGTTACTGCGCACAGCACCG
GTCTGCCAGGGCGACACAGTCAAGATCATGACCGGCGCCCCGGTCCCGGCAGGATGTGACACGGTGGTACCGATTGAGGA
CATTACGGAAGATGGCGGTGTGATCCGCCTGAATCGCTCAATCAAGCGCGGTTCCAATATCCGCAAGCAGGGCGAGGATA
TACTGAAGGGGAATCTGCTGATCAAGTCCGGCCATCCTGTCCGGCCTCAGGAGATCGGCCTTTTAGCATCATTCGGCTGG
TCAACCCTGCCGGTCTACCGCAAGCCGCGTATCGCCATTCTTGCCACGGGAGATGAACTGCTGGAGATCGGTTCGATCCC
CAGTCCGGGCAAGATCATCAACAGCAACAGCTACAGTCTGGCAGCCCAATTGATACAGGCCGGTGGAGAACCGGTGCTGA
TCGGCATTGCGGCAGACACCAGGAAGGCGACCAGAGACAAGATTGTTGAGGGGTTGCAGGCGGATGGCCTGATCATCTCA
GGCGGCGCATCCGTGGGGGACCGCGACTTCGTCAGGGAAACGATCCTGGAACTGCAAGGCGAACTGCAGTTCAGCAAGGT
GAATATGAAGCCCGGCAAACCGGCGACCTTTGCCACAATCGGCAGTAAGCCGGTCTTCGCGCTCCCCGGCAATCCAGTCG
CGGCCATGGTCTGTTTTGAGATGTTCGTTCGCCCGGCCATTCTCAAGATGCTGGGGTATTCGCAGCTGATGCGGCCCACG
GTCAAGGCCGTGCTGTCCGGACAGGTCTTGAACAGCGGCGAACGTCCCCACCTGGTCAGCGTCCGGGTCGCCCCGGAAGG
GGACAGCTACAAGGCCTCCACCATCACCAACCAGAGCTCTGCCAACCTGGCATCACTGACAGCCGGCAACGGCTTGTTGA
GGCTGGAACCGCACTCGTTACTCTTGGCTGACAGCGTCGTTGAAATTACCTTGCTGGACCCGGACCTGGGCACGGGGGAT
ATTCATTATGGCACTCTATGA

Upstream 100 bases:

>100_bases
CACGCGTTACCCTCCGGATCACAGGTTCACCAGACCCCCGGAATCCGGAGCTGCACAGCCGACAAGACCAGTCATCCTGA
ACTATTTGTGAGGCTTCGTC

Downstream 100 bases:

>100_bases
TCCGTTTGGAAGGTCAATCAATTACCTGCGTCTTTCAGTAACCGACCGCTGCAATCTGCGCTGCATCTACTGCATGCCCG
CCGCAGGGGTACATGCCATA

Product: molybdenum cofactor synthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MISINAAQEIVLKHTTQIDSESVPLLEAIGRIIAVDMRAPHDLPLSNNSAMDGYALALRPGQEQWNVVDFIPAGLLRTAP
VCQGDTVKIMTGAPVPAGCDTVVPIEDITEDGGVIRLNRSIKRGSNIRKQGEDILKGNLLIKSGHPVRPQEIGLLASFGW
STLPVYRKPRIAILATGDELLEIGSIPSPGKIINSNSYSLAAQLIQAGGEPVLIGIAADTRKATRDKIVEGLQADGLIIS
GGASVGDRDFVRETILELQGELQFSKVNMKPGKPATFATIGSKPVFALPGNPVAAMVCFEMFVRPAILKMLGYSQLMRPT
VKAVLSGQVLNSGERPHLVSVRVAPEGDSYKASTITNQSSANLASLTAGNGLLRLEPHSLLLADSVVEITLLDPDLGTGD
IHYGTL

Sequences:

>Translated_406_residues
MISINAAQEIVLKHTTQIDSESVPLLEAIGRIIAVDMRAPHDLPLSNNSAMDGYALALRPGQEQWNVVDFIPAGLLRTAP
VCQGDTVKIMTGAPVPAGCDTVVPIEDITEDGGVIRLNRSIKRGSNIRKQGEDILKGNLLIKSGHPVRPQEIGLLASFGW
STLPVYRKPRIAILATGDELLEIGSIPSPGKIINSNSYSLAAQLIQAGGEPVLIGIAADTRKATRDKIVEGLQADGLIIS
GGASVGDRDFVRETILELQGELQFSKVNMKPGKPATFATIGSKPVFALPGNPVAAMVCFEMFVRPAILKMLGYSQLMRPT
VKAVLSGQVLNSGERPHLVSVRVAPEGDSYKASTITNQSSANLASLTAGNGLLRLEPHSLLLADSVVEITLLDPDLGTGD
IHYGTL
>Mature_406_residues
MISINAAQEIVLKHTTQIDSESVPLLEAIGRIIAVDMRAPHDLPLSNNSAMDGYALALRPGQEQWNVVDFIPAGLLRTAP
VCQGDTVKIMTGAPVPAGCDTVVPIEDITEDGGVIRLNRSIKRGSNIRKQGEDILKGNLLIKSGHPVRPQEIGLLASFGW
STLPVYRKPRIAILATGDELLEIGSIPSPGKIINSNSYSLAAQLIQAGGEPVLIGIAADTRKATRDKIVEGLQADGLIIS
GGASVGDRDFVRETILELQGELQFSKVNMKPGKPATFATIGSKPVFALPGNPVAAMVCFEMFVRPAILKMLGYSQLMRPT
VKAVLSGQVLNSGERPHLVSVRVAPEGDSYKASTITNQSSANLASLTAGNGLLRLEPHSLLLADSVVEITLLDPDLGTGD
IHYGTL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=34.6835443037975, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=34.6835443037975, Blast_Score=191, Evalue=7e-49,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=34.2931937172775, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=372, Percent_Identity=30.6451612903226, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=314, Percent_Identity=26.7515923566879, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17136978, Length=355, Percent_Identity=32.112676056338, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24638841, Length=355, Percent_Identity=32.112676056338, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43077; Mature: 43077

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISINAAQEIVLKHTTQIDSESVPLLEAIGRIIAVDMRAPHDLPLSNNSAMDGYALALRP
CEECCCHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECC
GQEQWNVVDFIPAGLLRTAPVCQGDTVKIMTGAPVPAGCDTVVPIEDITEDGGVIRLNRS
CCCCCCEEECCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCEEEEECC
IKRGSNIRKQGEDILKGNLLIKSGHPVRPQEIGLLASFGWSTLPVYRKPRIAILATGDEL
HHCCCCHHHHCHHHHCCCEEEECCCCCCHHHHCEEEECCCCCCCCCCCCCEEEEECCHHH
LEIGSIPSPGKIINSNSYSLAAQLIQAGGEPVLIGIAADTRKATRDKIVEGLQADGLIIS
HHHCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEE
GGASVGDRDFVRETILELQGELQFSKVNMKPGKPATFATIGSKPVFALPGNPVAAMVCFE
CCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHH
MFVRPAILKMLGYSQLMRPTVKAVLSGQVLNSGERPHLVSVRVAPEGDSYKASTITNQSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCC
ANLASLTAGNGLLRLEPHSLLLADSVVEITLLDPDLGTGDIHYGTL
CCEEEEECCCCEEEECCCCEEEECCEEEEEEECCCCCCCCEECCCC
>Mature Secondary Structure
MISINAAQEIVLKHTTQIDSESVPLLEAIGRIIAVDMRAPHDLPLSNNSAMDGYALALRP
CEECCCHHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEECC
GQEQWNVVDFIPAGLLRTAPVCQGDTVKIMTGAPVPAGCDTVVPIEDITEDGGVIRLNRS
CCCCCCEEECCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCEEEEECC
IKRGSNIRKQGEDILKGNLLIKSGHPVRPQEIGLLASFGWSTLPVYRKPRIAILATGDEL
HHCCCCHHHHCHHHHCCCEEEECCCCCCHHHHCEEEECCCCCCCCCCCCCEEEEECCHHH
LEIGSIPSPGKIINSNSYSLAAQLIQAGGEPVLIGIAADTRKATRDKIVEGLQADGLIIS
HHHCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEE
GGASVGDRDFVRETILELQGELQFSKVNMKPGKPATFATIGSKPVFALPGNPVAAMVCFE
CCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHH
MFVRPAILKMLGYSQLMRPTVKAVLSGQVLNSGERPHLVSVRVAPEGDSYKASTITNQSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCC
ANLASLTAGNGLLRLEPHSLLLADSVVEITLLDPDLGTGDIHYGTL
CCEEEEECCCCEEEECCCCEEEECCEEEEEEECCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]