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The map label for this gene is moaA [H]

Identifier: 189423958

GI number: 189423958

Start: 922163

End: 923143

Strand: Reverse

Name: moaA [H]

Synonym: Glov_0892

Alternate gene names: 189423958

Gene position: 923143-922163 (Counterclockwise)

Preceding gene: 189423959

Following gene: 189423957

Centisome position: 23.56

GC content: 56.57

Gene sequence:

>981_bases
ATGGCACTCTATGATCCGTTTGGAAGGTCAATCAATTACCTGCGTCTTTCAGTAACCGACCGCTGCAATCTGCGCTGCAT
CTACTGCATGCCCGCCGCAGGGGTACATGCCATAAAGCATGCGGATGTACTGAGTTTTGAAGAGCTGCTCACGGTCTCCC
GGGCTGCCGTTGCTATTGGCGTTGAAAAGATCAGGGTTACCGGCGGCGAACCGCTGGTACGCAAAGGGATCATCCCCTTT
CTGGCAGAGCTGGCCACCACCCCCGGTCTGAAACGTCTGGTACTGACGACAAACGGCATCCTGTTGCCGGAGATGGCGGC
AGAACTGCGCTGTGCCGGTGTTGAAAGCCTGAATATCAGTCTCGATTCACTGCAGCCGGACACCTTTGACAGCATCACCC
GCGGCGGAAACATCCTGAAGGTTTTTGAAGGGATCAAGGCAGCAGAAGAGGCCGGATTCAAGCGGATCAAGATCAATATG
GTGGTGATACGCGGCGTCAATGACCATGAAGTGGCAGACTTTGCCGCTCTGACGCTCAAAAGGCCCTACCACGTCAGATT
CATCGAATATATGCCGACCCTGCGGGATGACTCCTGGAAGGCACGTACCATTTCCGGCAGTGAAATCCTCGGCAAGCTGG
CCCTGCGCTACTCCCTGCAAGCGGAGAGCAAGGCAGCCATGGACGGACCGGCCAGCTATTACCGGATTGCAGGAGCGGCC
GGCAGAGTCGGCGTCATCACACCGGTATCATGCCACTTCTGCAATGAATGCAACCGGATCAGGGTTACCTCAACCGGGAT
TGCCAAAAGCTGCCTGTTTGCAACCGAGACCCACGACCTGAAGCCCTACATCCATGCCGGAGACGATCAGGCACTCAGAG
ATGCGCTGCGCTACGTGGTCACCACCAAACCTGAACACCACGCAATCGAGGAGCGGGCCCAGAGAAACATGACGATGCCG
ATGTCACAGGTGGGTGGCTAA

Upstream 100 bases:

>100_bases
AACGGCTTGTTGAGGCTGGAACCGCACTCGTTACTCTTGGCTGACAGCGTCGTTGAAATTACCTTGCTGGACCCGGACCT
GGGCACGGGGGATATTCATT

Downstream 100 bases:

>100_bases
GGCTCCGGACACACTCATGGAGTCAACGGCGGTACGACCGGATTTGAGATACAAGCGGGGAACTCTGACATGCATCTGAA
ACTGACCCCAAAGGCGCACA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MALYDPFGRSINYLRLSVTDRCNLRCIYCMPAAGVHAIKHADVLSFEELLTVSRAAVAIGVEKIRVTGGEPLVRKGIIPF
LAELATTPGLKRLVLTTNGILLPEMAAELRCAGVESLNISLDSLQPDTFDSITRGGNILKVFEGIKAAEEAGFKRIKINM
VVIRGVNDHEVADFAALTLKRPYHVRFIEYMPTLRDDSWKARTISGSEILGKLALRYSLQAESKAAMDGPASYYRIAGAA
GRVGVITPVSCHFCNECNRIRVTSTGIAKSCLFATETHDLKPYIHAGDDQALRDALRYVVTTKPEHHAIEERAQRNMTMP
MSQVGG

Sequences:

>Translated_326_residues
MALYDPFGRSINYLRLSVTDRCNLRCIYCMPAAGVHAIKHADVLSFEELLTVSRAAVAIGVEKIRVTGGEPLVRKGIIPF
LAELATTPGLKRLVLTTNGILLPEMAAELRCAGVESLNISLDSLQPDTFDSITRGGNILKVFEGIKAAEEAGFKRIKINM
VVIRGVNDHEVADFAALTLKRPYHVRFIEYMPTLRDDSWKARTISGSEILGKLALRYSLQAESKAAMDGPASYYRIAGAA
GRVGVITPVSCHFCNECNRIRVTSTGIAKSCLFATETHDLKPYIHAGDDQALRDALRYVVTTKPEHHAIEERAQRNMTMP
MSQVGG
>Mature_325_residues
ALYDPFGRSINYLRLSVTDRCNLRCIYCMPAAGVHAIKHADVLSFEELLTVSRAAVAIGVEKIRVTGGEPLVRKGIIPFL
AELATTPGLKRLVLTTNGILLPEMAAELRCAGVESLNISLDSLQPDTFDSITRGGNILKVFEGIKAAEEAGFKRIKINMV
VIRGVNDHEVADFAALTLKRPYHVRFIEYMPTLRDDSWKARTISGSEILGKLALRYSLQAESKAAMDGPASYYRIAGAAG
RVGVITPVSCHFCNECNRIRVTSTGIAKSCLFATETHDLKPYIHAGDDQALRDALRYVVTTKPEHHAIEERAQRNMTMPM
SQVGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=326, Percent_Identity=40.1840490797546, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI22027536, Length=326, Percent_Identity=40.1840490797546, Blast_Score=241, Evalue=7e-64,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=34.9544072948328, Blast_Score=194, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=327, Percent_Identity=37.3088685015291, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17561210, Length=332, Percent_Identity=35.5421686746988, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566331, Length=310, Percent_Identity=38.0645161290323, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI28574488, Length=329, Percent_Identity=39.5136778115502, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574490, Length=311, Percent_Identity=40.5144694533762, Blast_Score=219, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35776; Mature: 35645

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYDPFGRSINYLRLSVTDRCNLRCIYCMPAAGVHAIKHADVLSFEELLTVSRAAVAIG
CCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHEE
VEKIRVTGGEPLVRKGIIPFLAELATTPGLKRLVLTTNGILLPEMAAELRCAGVESLNIS
EEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCEECHHHHHHHHHCCCCEEEEE
LDSLQPDTFDSITRGGNILKVFEGIKAAEEAGFKRIKINMVVIRGVNDHEVADFAALTLK
EECCCCCCHHHHHCCCCEEEHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHCC
RPYHVRFIEYMPTLRDDSWKARTISGSEILGKLALRYSLQAESKAAMDGPASYYRIAGAA
CCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCC
GRVGVITPVSCHFCNECNRIRVTSTGIAKSCLFATETHDLKPYIHAGDDQALRDALRYVV
CCEEEECCCCHHHCCCCCEEEEEECCCHHHHEEECCCCCCCCEEECCCCHHHHHHHHHHH
TTKPEHHAIEERAQRNMTMPMSQVGG
CCCCCHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
ALYDPFGRSINYLRLSVTDRCNLRCIYCMPAAGVHAIKHADVLSFEELLTVSRAAVAIG
CCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHEE
VEKIRVTGGEPLVRKGIIPFLAELATTPGLKRLVLTTNGILLPEMAAELRCAGVESLNIS
EEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCEECHHHHHHHHHCCCCEEEEE
LDSLQPDTFDSITRGGNILKVFEGIKAAEEAGFKRIKINMVVIRGVNDHEVADFAALTLK
EECCCCCCHHHHHCCCCEEEHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHCC
RPYHVRFIEYMPTLRDDSWKARTISGSEILGKLALRYSLQAESKAAMDGPASYYRIAGAA
CCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEECCC
GRVGVITPVSCHFCNECNRIRVTSTGIAKSCLFATETHDLKPYIHAGDDQALRDALRYVV
CCEEEECCCCHHHCCCCCEEEEEECCCHHHHEEECCCCCCCCEEECCCCHHHHHHHHHHH
TTKPEHHAIEERAQRNMTMPMSQVGG
CCCCCHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA