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The map label for this gene is prsA [H]

Identifier: 189423768

GI number: 189423768

Start: 708771

End: 709688

Strand: Reverse

Name: prsA [H]

Synonym: Glov_0699

Alternate gene names: 189423768

Gene position: 709688-708771 (Counterclockwise)

Preceding gene: 189423769

Following gene: 189423767

Centisome position: 18.11

GC content: 53.49

Gene sequence:

>918_bases
GTGAACATCCGTACTTTGCTTAGCGTAACCGTTACCGTCATTGCCACCGCAGGCCTGGTTGCCTGCCAGGGCGGCGGTTC
CAGCAGCAGCTCAACCAGCAGCAAGGATGCCAAGGTAATTGCCACCGTCAACGGTGCGAAGATTACCAGTGAAGACTTTG
ACCGTGAAGTCAAGGCGTTGCCTGAGTATATCCGTGCCATGGCAGACACCCCGCAGGGCAAAAAAGAGATGATCGACACA
CTGGTCATGCGTGAACTGATCCTGCAGCAGGCTGCCAAAGACGGCGTTGACAAGGGCAAGGAAATTGAAGAAAAACTTGC
TGAACTCAAGAAGCGGATCATTGTCGACACCTACCTCAAGAAAAAGGTTGAAGCCGAATCCAAAATCAGCGATGACGAGT
TGAAGAAGTTTTATGAGCAGAATCTTGACAAATTCAAGGCAGGTGAGCAGATCCGCGCCAGCCACATCCTGGTCAAGAGT
GAGCAGGAAGCACAGTCAATCCTGGAGCAACTCAAGAAAGGGGCCAACTTTGAAGAGCTGGCCAAGACCAAATCTGCAGA
CTCATCTGCTGCTAAAGGGGGTGACCTGGGCTGGTTCGGCAAGGGCAACATGGTGCCGGCCTTTGAAAAGGCAGCCTTTG
GCCTGAAAGAGGGGCAACTGTCCGGTATTGTCAAGAGCGACTTCGGTTACCACATCATCAAGCTGACCGGCAAGCGTGCT
GCCGGAACCCGCCCTCTGGATGAGGTAAAAGAGCAGATCAAGGGTGCCATCATGCCCCAGAAGCAGCAACAGGTATTCAT
GAAGCTGAAAGAAGACCTGAAAAAAGGCGCCAAGATCGAGCTGACCGATGCACAACCGGCTGCCCCGGCTGCCAAGCCTG
CCGCTCCAGCTCCAGCTCCTGCAGCAGAAAAGAAATAA

Upstream 100 bases:

>100_bases
AGGATCCACCTTCAGAACAGGGCCTTGCAACCGGTTGGCAAGCTATGGTAGATTTACTAAGTTTCATCAACCCTTTCTTA
CATTCAAAGGAGTCTCAATC

Downstream 100 bases:

>100_bases
TCGCTATTAACGTGATCCAGGCCGGGCAGCCAGTTGGTTGCCCGGCCTGCTTTCGAGGCCTTCATGAATCATCTTCGCCT
GCTTTCCCTTGCCTCCCTCC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNIRTLLSVTVTVIATAGLVACQGGGSSSSSTSSKDAKVIATVNGAKITSEDFDREVKALPEYIRAMADTPQGKKEMIDT
LVMRELILQQAAKDGVDKGKEIEEKLAELKKRIIVDTYLKKKVEAESKISDDELKKFYEQNLDKFKAGEQIRASHILVKS
EQEAQSILEQLKKGANFEELAKTKSADSSAAKGGDLGWFGKGNMVPAFEKAAFGLKEGQLSGIVKSDFGYHIIKLTGKRA
AGTRPLDEVKEQIKGAIMPQKQQQVFMKLKEDLKKGAKIELTDAQPAAPAAKPAAPAPAPAAEKK

Sequences:

>Translated_305_residues
MNIRTLLSVTVTVIATAGLVACQGGGSSSSSTSSKDAKVIATVNGAKITSEDFDREVKALPEYIRAMADTPQGKKEMIDT
LVMRELILQQAAKDGVDKGKEIEEKLAELKKRIIVDTYLKKKVEAESKISDDELKKFYEQNLDKFKAGEQIRASHILVKS
EQEAQSILEQLKKGANFEELAKTKSADSSAAKGGDLGWFGKGNMVPAFEKAAFGLKEGQLSGIVKSDFGYHIIKLTGKRA
AGTRPLDEVKEQIKGAIMPQKQQQVFMKLKEDLKKGAKIELTDAQPAAPAAKPAAPAPAPAAEKK
>Mature_305_residues
MNIRTLLSVTVTVIATAGLVACQGGGSSSSSTSSKDAKVIATVNGAKITSEDFDREVKALPEYIRAMADTPQGKKEMIDT
LVMRELILQQAAKDGVDKGKEIEEKLAELKKRIIVDTYLKKKVEAESKISDDELKKFYEQNLDKFKAGEQIRASHILVKS
EQEAQSILEQLKKGANFEELAKTKSADSSAAKGGDLGWFGKGNMVPAFEKAAFGLKEGQLSGIVKSDFGYHIIKLTGKRA
AGTRPLDEVKEQIKGAIMPQKQQQVFMKLKEDLKKGAKIELTDAQPAAPAAKPAAPAPAPAAEKK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=102, Percent_Identity=38.2352941176471, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786645, Length=151, Percent_Identity=37.0860927152318, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=50.6024096385542, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786238, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=99, Percent_Identity=37.3737373737374, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=112, Percent_Identity=41.9642857142857, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17647355, Length=82, Percent_Identity=51.219512195122, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356303, Length=100, Percent_Identity=39, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32960; Mature: 32960

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRTLLSVTVTVIATAGLVACQGGGSSSSSTSSKDAKVIATVNGAKITSEDFDREVKAL
CCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
PEYIRAMADTPQGKKEMIDTLVMRELILQQAAKDGVDKGKEIEEKLAELKKRIIVDTYLK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KKVEAESKISDDELKKFYEQNLDKFKAGEQIRASHILVKSEQEAQSILEQLKKGANFEEL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHCCCCHHHH
AKTKSADSSAAKGGDLGWFGKGNMVPAFEKAAFGLKEGQLSGIVKSDFGYHIIKLTGKRA
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCC
AGTRPLDEVKEQIKGAIMPQKQQQVFMKLKEDLKKGAKIELTDAQPAAPAAKPAAPAPAP
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCC
AAEKK
CCCCC
>Mature Secondary Structure
MNIRTLLSVTVTVIATAGLVACQGGGSSSSSTSSKDAKVIATVNGAKITSEDFDREVKAL
CCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
PEYIRAMADTPQGKKEMIDTLVMRELILQQAAKDGVDKGKEIEEKLAELKKRIIVDTYLK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KKVEAESKISDDELKKFYEQNLDKFKAGEQIRASHILVKSEQEAQSILEQLKKGANFEEL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHCCCCHHHH
AKTKSADSSAAKGGDLGWFGKGNMVPAFEKAAFGLKEGQLSGIVKSDFGYHIIKLTGKRA
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCC
AGTRPLDEVKEQIKGAIMPQKQQQVFMKLKEDLKKGAKIELTDAQPAAPAAKPAAPAPAP
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCC
AAEKK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]