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The map label for this gene is hemC

Identifier: 189423573

GI number: 189423573

Start: 477622

End: 478560

Strand: Reverse

Name: hemC

Synonym: Glov_0502

Alternate gene names: 189423573

Gene position: 478560-477622 (Counterclockwise)

Preceding gene: 189423574

Following gene: 189423572

Centisome position: 12.22

GC content: 60.49

Gene sequence:

>939_bases
ATGGCACCTAAACGCCTCCGCATAGGCACCCGCGCCAGCCAGCTGGCCCTCTGGCAGGCCAACTGGACCAAATCGGAACT
GGAAGCAAGGTATCCCGGCATCCAGGTTGAACTGGTCAAGATCAAGACCATGGGAGACAAGATCCTGGATGTCCCACTGG
CACAGGTTGGTGGCAAAGGACTGTTTGTCAAAGAGATCGAAGAGGCAATGCTGCGGGGTGAGATCGACCTGGCCGTACAC
AGCATGAAGGATGTCCCGACTGAGTTCCCTGAAGGACTGGGACTGGTGGTAACCACCAAGCGTGAAGACCCCCGTGACGC
CTTTATCTCGGACAAGGTAACATTCAGCGAACTGCGCCAGGGAGCCAGAATAGGCACCAGTGCCCTGCGCAGACAGGCCC
AGCTGCTCAAGGCGCGGCCCGACCTGGAGATGGTGATTATCCGCGGCAACGTTGAGACCCGTATTCGCAAGCTGAAGGAA
GACAATCTGGATGCCGTGATCCTGGCAGCGGCCGGCCTGAACCGGCTCGGCTTCACCGACGTGGTGACCGAGCTGCTGGA
TACGGACTTCTCGATCCCGGCCATCGGCCAGGGCGCCCTGGGACTGGAGTGCCGCCTGGATGACAACGCCACCATCGAGG
CGCTGGCCTTCCTGAATCATGCCGATACCGCTGCTGCAGTGGCCGCAGAACGGGCGCTGCTCAAACGCTGTGAAGGTGGT
TGCCAGGTACCGATTGCCGCCCACGGCACGGTGAGCGGTGACACCCTGACCCTGGTCGGTTTTATCGCCTCGGTGGATGG
CAAACAGACGGTACGGGACCGCATCAGCGGATCAACAGCGGATGCGGTAAAACTGGGAACAGAACTGGCCGACCGGTTGC
TGGCAGCTGGAGGCAAGGCGATTCTGGAAGATGTCTACCAGCGGGAAATTGCCCACTAG

Upstream 100 bases:

>100_bases
GGATGCCCTGCGAGCGCTGTTTGATCTGGAACTGGGCGGCACCGACACGAATGAATCACTTGAATTGGAAGAATAACCGG
AGATAAAGGAGATTGTACAC

Downstream 100 bases:

>100_bases
CCCCCTACGGGGCTGCCGGATTCTGGTGACCCGCGCGGCAGAGCAGGCTGCCGGGTTCTCCCGGCAGTTACAACAGCGTG
GCGCTGTGGTGGTGGAATGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDLAVH
SMKDVPTEFPEGLGLVVTTKREDPRDAFISDKVTFSELRQGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKE
DNLDAVILAAAGLNRLGFTDVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGG
CQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILEDVYQREIAH

Sequences:

>Translated_312_residues
MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDLAVH
SMKDVPTEFPEGLGLVVTTKREDPRDAFISDKVTFSELRQGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKE
DNLDAVILAAAGLNRLGFTDVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGG
CQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILEDVYQREIAH
>Mature_311_residues
APKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDLAVHS
MKDVPTEFPEGLGLVVTTKREDPRDAFISDKVTFSELRQGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKED
NLDAVILAAAGLNRLGFTDVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGGC
QVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILEDVYQREIAH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=341, Percent_Identity=38.41642228739, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI66933009, Length=341, Percent_Identity=38.41642228739, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=52.8052805280528, Blast_Score=308, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=36.4485981308411, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI20130425, Length=288, Percent_Identity=36.1111111111111, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_GEOLS (B3E2H7)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001950750.1
- ProteinModelPortal:   B3E2H7
- SMR:   B3E2H7
- GeneID:   6367435
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_0502
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33656; Mature: 33525

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG
CCCCCCCCCCCHHHEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCHHHHCCHHHHCCCC
LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFISDKVTFSELRQ
EEHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCHHHHHC
GARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFTD
CHHCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
VVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGG
HHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCC
CQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKA
CEEEEEECCCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
ILEDVYQREIAH
HHHHHHHHHHCC
>Mature Secondary Structure 
APKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG
CCCCCCCCCCHHHEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCHHHHCCHHHHCCCC
LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFISDKVTFSELRQ
EEHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCHHHHHC
GARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFTD
CHHCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
VVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGG
HHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCC
CQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKA
CEEEEEECCCCCCCCEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
ILEDVYQREIAH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA