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The map label for this gene is hemD [H]

Identifier: 189423572

GI number: 189423572

Start: 476820

End: 477650

Strand: Reverse

Name: hemD [H]

Synonym: Glov_0501

Alternate gene names: 189423572

Gene position: 477650-476820 (Counterclockwise)

Preceding gene: 189423573

Following gene: 189423558

Centisome position: 12.19

GC content: 62.09

Gene sequence:

>831_bases
ATGTCTACCAGCGGGAAATTGCCCACTAGCCCCCTACGGGGCTGCCGGATTCTGGTGACCCGCGCGGCAGAGCAGGCTGC
CGGGTTCTCCCGGCAGTTACAACAGCGTGGCGCTGTGGTGGTGGAATGCCCTACCATTCAGCTGGTGCCACCTGAAGCCT
GGACCGCTGTGGATGCTGCCATCCAGGCTTTATCCGGCTTTGACTGGCTGATCCTGACCTCGGCAAACGGGGTCAGGTTT
TTCTTTGGCCGGTTACAGGAACTGGGGCTTGCCCCCGCTGGACTGCAGAGCTGTAAGGTCTGCGCGGTCGGGCCTAAGAC
CGCAGAGGCCCTGACGCAGCTGGGTATCACACCTGATCTTATCCCGGAACAGTTCACCGGAGAAGGAGTGGTGGCCGCGT
TTCACGGACATGACCTGCAGGGGCGGCGGGTACTGTTTCCCAAGGCAGATGGTGCCCGCGACCTGATTCCGCAGCAACTG
CGCAGTAGGGGGGCCGTGGTGATTGACCCGGTGCTCTACCGCAACATCATCCCGCAGGGTTTGCCTGACTCTGCCCGTCT
GGCCCTGGAACAGCACCAGCTTGATGCGGTTGTCTTCAGTTCCCCTTCAACCGTTCGCAACCTGGCACAGTTGACGGGCG
GCATCACCCGGCTGCAGGCATTGCTGGCAGATCTGGCTGTGGTCTCCATCGGGCCGGTAACAACCAGGGCCTGTCAGGAG
CTGGGGCTTAGCGTTGCCGTGGAACCGGAACAGTCAACCCTGGATGCCCTGATTCGTGCCCTTGAGCAGCATACCCTCTG
CTGCCCCTCCGCTACGCCTCCCATCACCTAA

Upstream 100 bases:

>100_bases
GTACGGGACCGCATCAGCGGATCAACAGCGGATGCGGTAAAACTGGGAACAGAACTGGCCGACCGGTTGCTGGCAGCTGG
AGGCAAGGCGATTCTGGAAG

Downstream 100 bases:

>100_bases
TTCACCAGGCGCTTCAATACCCCGATGGCAAACTCCTGTGCCCCCAGCACGGAGGCCTGGGTCACCACCATGTTTGCGTT
CTGCAGCTGCTGGGCCACCA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSTSGKLPTSPLRGCRILVTRAAEQAAGFSRQLQQRGAVVVECPTIQLVPPEAWTAVDAAIQALSGFDWLILTSANGVRF
FFGRLQELGLAPAGLQSCKVCAVGPKTAEALTQLGITPDLIPEQFTGEGVVAAFHGHDLQGRRVLFPKADGARDLIPQQL
RSRGAVVIDPVLYRNIIPQGLPDSARLALEQHQLDAVVFSSPSTVRNLAQLTGGITRLQALLADLAVVSIGPVTTRACQE
LGLSVAVEPEQSTLDALIRALEQHTLCCPSATPPIT

Sequences:

>Translated_276_residues
MSTSGKLPTSPLRGCRILVTRAAEQAAGFSRQLQQRGAVVVECPTIQLVPPEAWTAVDAAIQALSGFDWLILTSANGVRF
FFGRLQELGLAPAGLQSCKVCAVGPKTAEALTQLGITPDLIPEQFTGEGVVAAFHGHDLQGRRVLFPKADGARDLIPQQL
RSRGAVVIDPVLYRNIIPQGLPDSARLALEQHQLDAVVFSSPSTVRNLAQLTGGITRLQALLADLAVVSIGPVTTRACQE
LGLSVAVEPEQSTLDALIRALEQHTLCCPSATPPIT
>Mature_275_residues
STSGKLPTSPLRGCRILVTRAAEQAAGFSRQLQQRGAVVVECPTIQLVPPEAWTAVDAAIQALSGFDWLILTSANGVRFF
FGRLQELGLAPAGLQSCKVCAVGPKTAEALTQLGITPDLIPEQFTGEGVVAAFHGHDLQGRRVLFPKADGARDLIPQQLR
SRGAVVIDPVLYRNIIPQGLPDSARLALEQHQLDAVVFSSPSTVRNLAQLTGGITRLQALLADLAVVSIGPVTTRACQEL
GLSVAVEPEQSTLDALIRALEQHTLCCPSATPPIT

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29248; Mature: 29117

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSGKLPTSPLRGCRILVTRAAEQAAGFSRQLQQRGAVVVECPTIQLVPPEAWTAVDAA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCHHHHHHHHH
IQALSGFDWLILTSANGVRFFFGRLQELGLAPAGLQSCKVCAVGPKTAEALTQLGITPDL
HHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCC
IPEQFTGEGVVAAFHGHDLQGRRVLFPKADGARDLIPQQLRSRGAVVIDPVLYRNIIPQG
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECHHHHHHHCCCC
LPDSARLALEQHQLDAVVFSSPSTVRNLAQLTGGITRLQALLADLAVVSIGPVTTRACQE
CCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LGLSVAVEPEQSTLDALIRALEQHTLCCPSATPPIT
CCCEEEECCCHHHHHHHHHHHHHCCEECCCCCCCCC
>Mature Secondary Structure 
STSGKLPTSPLRGCRILVTRAAEQAAGFSRQLQQRGAVVVECPTIQLVPPEAWTAVDAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCHHHHHHHHH
IQALSGFDWLILTSANGVRFFFGRLQELGLAPAGLQSCKVCAVGPKTAEALTQLGITPDL
HHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCC
IPEQFTGEGVVAAFHGHDLQGRRVLFPKADGARDLIPQQLRSRGAVVIDPVLYRNIIPQG
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECHHHHHHHCCCC
LPDSARLALEQHQLDAVVFSSPSTVRNLAQLTGGITRLQALLADLAVVSIGPVTTRACQE
CCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LGLSVAVEPEQSTLDALIRALEQHTLCCPSATPPIT
CCCEEEECCCHHHHHHHHHHHHHCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]