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The map label for this gene is tdcB [H]

Identifier: 189423551

GI number: 189423551

Start: 455552

End: 456772

Strand: Reverse

Name: tdcB [H]

Synonym: Glov_0480

Alternate gene names: 189423551

Gene position: 456772-455552 (Counterclockwise)

Preceding gene: 189423552

Following gene: 189423550

Centisome position: 11.66

GC content: 59.62

Gene sequence:

>1221_bases
ATGGAATCAATAACTCTCAACTATGAGCTGGTGCTGGAAGCCCAGGATCGTCTGCGCAAACGGGTTCGCCATACAGAGCT
GATCAGCTCCAATCACTTCAGCCGCCAACTGGGCTATCCCCTGCTGCTCAAGTGCGAAAACCTGCAGACCACCGGGGCCT
TCAAACTGCGCGGCGCCATGAACTTTATGACTGCCCGCGACCGTTCCGGGCTGGCTCAGGGGGTCACGGCGGCCTCGGCC
GGCAACCATGCCCAGGGGGTGGCCTATGCTGCCGACCTGTTGGGGGTACCGGCCAAGATCTTCATGCCGGAAAGCACGCC
GCCCCAGAAGGTACAGGCCACCCGCGACCTGGGGGCTGAAGTGGTGCTGACCGGTGCCAACTTTGATGAATCCTTTGCAG
CGGCCCAGGCAGACAGTAACCAGCATGGCACCGTATTCATCCATCCCTTTGATGACCCGCTGGTGATGGCTGGTCAGGGT
ACCATCGGCCTGGAGATACTGAAAGACCTGCCGGATGTTGCCAACCTGCTGGTGCCGATTGGTGGTGGCGGCCTGCTGGC
CGGCATTGCAACGGCCATCAAGGAGCATAACCCGCAAGTACGGATCATCGGTGTTGAATCTGCGGCAGCCCCCTGTATGT
TCCGGGCCGTGCATGATAACGCTATTGCTGAAGTTCCGCTGGGCACCACCATTGCCGACGGTATTGCGGTCAAAAAAGCC
GGTCAGATTACCACGCCGATCATCCAAAACCTGGTGGATGACCTGGTGCTGGTGGAAGAGGAAGAGATTGCCCTGGCAAT
TGTGGCATTGCTGGAAAAAAGCAAGCTTTTGGTGGAAGGGGCCGGGGCCGTGCCCCTGGCTGCCCTGCTGAATGGCCGTG
CAAAGGGAATCCGTGGTAAGACCGTCTGCCTGCTTTCCGGTGGCAACATTGATGTCCGCACCCTGGCGCTGGTGGTGGAA
CGTGGTCTGCTGGCTGCAGGCCGCTATCTGAAACTGCGGATTGAGATGCAGGACACCCCCGGCGCCCTGGCCCATCTGGC
CACAGATCTGGCAGAGGCCAAAGCCAATATTCACGATATCACCCATGATCGCCGCACCAAGGGGTTGGTGATGGGCACCA
CTGCCGTACAGCTGCTACTGGAGACCCGTGGCCAGGAACATGCCCACGAGGTACTCGGCCTGCTTGCAAAACGCGGCTAT
TCTGTCACAACGGAGCAGTAA

Upstream 100 bases:

>100_bases
AGAAGGCAAGGGTGATGACCAGAAGGCAATCGTCTGGTTTGCCGGTTGCGGCCCGAAAAAACTGCTGCTGAGATTTGCCG
GACTGGAGCGGGCGTAGACC

Downstream 100 bases:

>100_bases
CCATTATGCGGATTCTTGTTACCGGCGCAGCCGGATTCATCGGTTTTCACCTCTGCCGGCGCCTGCTGGCACGGGGCGAT
GCGGTCCTGGGGCTGGACAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MESITLNYELVLEAQDRLRKRVRHTELISSNHFSRQLGYPLLLKCENLQTTGAFKLRGAMNFMTARDRSGLAQGVTAASA
GNHAQGVAYAADLLGVPAKIFMPESTPPQKVQATRDLGAEVVLTGANFDESFAAAQADSNQHGTVFIHPFDDPLVMAGQG
TIGLEILKDLPDVANLLVPIGGGGLLAGIATAIKEHNPQVRIIGVESAAAPCMFRAVHDNAIAEVPLGTTIADGIAVKKA
GQITTPIIQNLVDDLVLVEEEEIALAIVALLEKSKLLVEGAGAVPLAALLNGRAKGIRGKTVCLLSGGNIDVRTLALVVE
RGLLAAGRYLKLRIEMQDTPGALAHLATDLAEAKANIHDITHDRRTKGLVMGTTAVQLLLETRGQEHAHEVLGLLAKRGY
SVTTEQ

Sequences:

>Translated_406_residues
MESITLNYELVLEAQDRLRKRVRHTELISSNHFSRQLGYPLLLKCENLQTTGAFKLRGAMNFMTARDRSGLAQGVTAASA
GNHAQGVAYAADLLGVPAKIFMPESTPPQKVQATRDLGAEVVLTGANFDESFAAAQADSNQHGTVFIHPFDDPLVMAGQG
TIGLEILKDLPDVANLLVPIGGGGLLAGIATAIKEHNPQVRIIGVESAAAPCMFRAVHDNAIAEVPLGTTIADGIAVKKA
GQITTPIIQNLVDDLVLVEEEEIALAIVALLEKSKLLVEGAGAVPLAALLNGRAKGIRGKTVCLLSGGNIDVRTLALVVE
RGLLAAGRYLKLRIEMQDTPGALAHLATDLAEAKANIHDITHDRRTKGLVMGTTAVQLLLETRGQEHAHEVLGLLAKRGY
SVTTEQ
>Mature_406_residues
MESITLNYELVLEAQDRLRKRVRHTELISSNHFSRQLGYPLLLKCENLQTTGAFKLRGAMNFMTARDRSGLAQGVTAASA
GNHAQGVAYAADLLGVPAKIFMPESTPPQKVQATRDLGAEVVLTGANFDESFAAAQADSNQHGTVFIHPFDDPLVMAGQG
TIGLEILKDLPDVANLLVPIGGGGLLAGIATAIKEHNPQVRIIGVESAAAPCMFRAVHDNAIAEVPLGTTIADGIAVKKA
GQITTPIIQNLVDDLVLVEEEEIALAIVALLEKSKLLVEGAGAVPLAALLNGRAKGIRGKTVCLLSGGNIDVRTLALVVE
RGLLAAGRYLKLRIEMQDTPGALAHLATDLAEAKANIHDITHDRRTKGLVMGTTAVQLLLETRGQEHAHEVLGLLAKRGY
SVTTEQ

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=35.3312302839117, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI19923959, Length=303, Percent_Identity=32.3432343234323, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI33469958, Length=270, Percent_Identity=31.1111111111111, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI295821202, Length=202, Percent_Identity=31.6831683168317, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI295821200, Length=202, Percent_Identity=31.6831683168317, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4557415, Length=202, Percent_Identity=31.6831683168317, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=310, Percent_Identity=46.1290322580645, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790207, Length=382, Percent_Identity=36.6492146596859, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1789235, Length=225, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=395, Percent_Identity=40.253164556962, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17537387, Length=377, Percent_Identity=35.5437665782493, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=307, Percent_Identity=28.9902280130293, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=322, Percent_Identity=38.1987577639752, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=35.7594936708861, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=188, Percent_Identity=29.7872340425532, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=365, Percent_Identity=40.2739726027397, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24645328, Length=301, Percent_Identity=40.531561461794, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43037; Mature: 43037

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESITLNYELVLEAQDRLRKRVRHTELISSNHFSRQLGYPLLLKCENLQTTGAFKLRGAM
CCEEEEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCEEEEECHH
NFMTARDRSGLAQGVTAASAGNHAQGVAYAADLLGVPAKIFMPESTPPQKVQATRDLGAE
HHHHHCCCCCHHHCCHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCE
VVLTGANFDESFAAAQADSNQHGTVFIHPFDDPLVMAGQGTIGLEILKDLPDVANLLVPI
EEEECCCCCHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCHHHHHHEEEC
GGGGLLAGIATAIKEHNPQVRIIGVESAAAPCMFRAVHDNAIAEVPLGTTIADGIAVKKA
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHCCCEEECCCCCHHHCCEEEECC
GQITTPIIQNLVDDLVLVEEEEIALAIVALLEKSKLLVEGAGAVPLAALLNGRAKGIRGK
CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCCC
TVCLLSGGNIDVRTLALVVERGLLAAGRYLKLRIEMQDTPGALAHLATDLAEAKANIHDI
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
THDRRTKGLVMGTTAVQLLLETRGQEHAHEVLGLLAKRGYSVTTEQ
CCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MESITLNYELVLEAQDRLRKRVRHTELISSNHFSRQLGYPLLLKCENLQTTGAFKLRGAM
CCEEEEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCEEEEECHH
NFMTARDRSGLAQGVTAASAGNHAQGVAYAADLLGVPAKIFMPESTPPQKVQATRDLGAE
HHHHHCCCCCHHHCCHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCE
VVLTGANFDESFAAAQADSNQHGTVFIHPFDDPLVMAGQGTIGLEILKDLPDVANLLVPI
EEEECCCCCHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCHHHHHHEEEC
GGGGLLAGIATAIKEHNPQVRIIGVESAAAPCMFRAVHDNAIAEVPLGTTIADGIAVKKA
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHCCCEEECCCCCHHHCCEEEECC
GQITTPIIQNLVDDLVLVEEEEIALAIVALLEKSKLLVEGAGAVPLAALLNGRAKGIRGK
CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCCC
TVCLLSGGNIDVRTLALVVERGLLAAGRYLKLRIEMQDTPGALAHLATDLAEAKANIHDI
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
THDRRTKGLVMGTTAVQLLLETRGQEHAHEVLGLLAKRGYSVTTEQ
CCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA