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The map label for this gene is hemL [H]

Identifier: 189354052

GI number: 189354052

Start: 2380934

End: 2382292

Strand: Direct

Name: hemL [H]

Synonym: BMULJ_05305

Alternate gene names: 189354052

Gene position: 2380934-2382292 (Clockwise)

Preceding gene: 189354050

Following gene: 189354057

Centisome position: 96.27

GC content: 69.17

Gene sequence:

>1359_bases
TTGTCTTCCCGCCACGGAGTCGACCTCACCCGCGCCCGCGCGCTGTTCGACCGCGAGCGTCGCGCGTTCACCGAAGCCAT
GCCGATTTCCCGCGCGCTGTCCGCGGAAGCGGCGGAGCATCTGCTTTTCGGCGTGCCGTTGCACTGGATGCAGGATTGGT
CGACACCGTTTTCGCTGTACGTGAAGGAGGCGCGCGGCGCGACGTTTACCGACGTCGACGGGCACCGCTACGTCGACTTC
TGTCTCGGCGATACGGGCGCGATGTTCGGCCATGCGCCCGAGCCGGTCGCCCGCGCGCTCGCCGAGCAGGCGACACGCGG
CTACACGACGATGCTGCCGAGCGAGGATGCCGCGTGGGTGTCGCGCGAGCTCGCACGCCGGTTCCGCCTGCCGTTCTGGC
AGTTCGCGCTGAGCGCGAGCGACGCGAACCGCTTCGTGCTGCGCTGGGCGCGCGCCGCGACGGGCCGCAACACGATCGTC
GTGTTCAACGGCTGCTATCACGGCACCGTCGACGACGTCTTCGTCGATCTCGTCGACGGCCGCGCGGTGCAGCGCGACAG
CCTGCTCGGGCAATCGTACGACCTGCTCGCGAACACGCGCGTCGTCGAATTCAACGATCTGGACGCGCTCGAAGCGGCGC
TGAAGCACGACGACGTCGCGTGCGTGATCGCGGAACCCGCGATGACGAACATCGGCATGGTGCTGCCCGAGCCCGGCTTC
TGGCGCGAGGCGCGCGCGCTCACGCGCCGCTACGGCACGCTGCTCGTCATCGACGAAACGCACACGATCAGCAGCGGCCC
CGGCGGCTACGCGGTCGCGCACGATCTCGAACCGGACGTGCTCGTGGTCGGCAAGCCGATCGCGGGCGGCGTGCCGTGCG
CGGTGTACGGATTCAGCGCCGAATTCGCCGAACGCGCAAAGCAGGCGAAGCTGAACGCGCCGCCCGGCCATTCGGGCATA
GGCACGACGCTGACGGCGAACATGCTCGCGATGCATGCGATGCGCGCGACGCTCGCCGAGGTCGCGACCGACGCCGCGTA
TGCGCACATGTTCGAACTCGCCGCGCGCCTCGCGGCAGGGCTCGAGCAGACGATCGCGAAACACGCGCTGCCGTGGTGCG
TGACGCGCATCGGCGCGCGCACCGAGTTTCAGTTTGCGCCGACACCGCCGCGCAACGGCACGCTCGCCGGCGCGCAGCTC
GACAGCGAGCTCGAGCACATCGTGCATCTCTACCTGTTGAACCGCGGCGTGCTGATCACGCCGTTCCACAACATGATGCT
CGTGTGCCCGCAGACGACGGCCGACGACGTCGACCGGCTCGTCGCCGCGTTCGACGCGTGCCTGAGCGAGCTGACCTGA

Upstream 100 bases:

>100_bases
GGCGCGCGCCGCGTCTTCTCCGCCCCCGTGATTCCGCCCCCTGTTCAGCGGCCCGCCGCGCGCGCTATCGTGTCTGCTCC
TTCACAACCAGGAGCCGCAC

Downstream 100 bases:

>100_bases
GCGCTTGAGCCGCGCGGCGACACGCGCGGCCGGTCCGTCGCCGGTCGCCGCATTGCGCGACCGCCGGACCGCCGGACCGC
CGCGCGCTCCGCTCACGCGC

Product: aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSSRHGVDLTRARALFDRERRAFTEAMPISRALSAEAAEHLLFGVPLHWMQDWSTPFSLYVKEARGATFTDVDGHRYVDF
CLGDTGAMFGHAPEPVARALAEQATRGYTTMLPSEDAAWVSRELARRFRLPFWQFALSASDANRFVLRWARAATGRNTIV
VFNGCYHGTVDDVFVDLVDGRAVQRDSLLGQSYDLLANTRVVEFNDLDALEAALKHDDVACVIAEPAMTNIGMVLPEPGF
WREARALTRRYGTLLVIDETHTISSGPGGYAVAHDLEPDVLVVGKPIAGGVPCAVYGFSAEFAERAKQAKLNAPPGHSGI
GTTLTANMLAMHAMRATLAEVATDAAYAHMFELAARLAAGLEQTIAKHALPWCVTRIGARTEFQFAPTPPRNGTLAGAQL
DSELEHIVHLYLLNRGVLITPFHNMMLVCPQTTADDVDRLVAAFDACLSELT

Sequences:

>Translated_452_residues
MSSRHGVDLTRARALFDRERRAFTEAMPISRALSAEAAEHLLFGVPLHWMQDWSTPFSLYVKEARGATFTDVDGHRYVDF
CLGDTGAMFGHAPEPVARALAEQATRGYTTMLPSEDAAWVSRELARRFRLPFWQFALSASDANRFVLRWARAATGRNTIV
VFNGCYHGTVDDVFVDLVDGRAVQRDSLLGQSYDLLANTRVVEFNDLDALEAALKHDDVACVIAEPAMTNIGMVLPEPGF
WREARALTRRYGTLLVIDETHTISSGPGGYAVAHDLEPDVLVVGKPIAGGVPCAVYGFSAEFAERAKQAKLNAPPGHSGI
GTTLTANMLAMHAMRATLAEVATDAAYAHMFELAARLAAGLEQTIAKHALPWCVTRIGARTEFQFAPTPPRNGTLAGAQL
DSELEHIVHLYLLNRGVLITPFHNMMLVCPQTTADDVDRLVAAFDACLSELT
>Mature_451_residues
SSRHGVDLTRARALFDRERRAFTEAMPISRALSAEAAEHLLFGVPLHWMQDWSTPFSLYVKEARGATFTDVDGHRYVDFC
LGDTGAMFGHAPEPVARALAEQATRGYTTMLPSEDAAWVSRELARRFRLPFWQFALSASDANRFVLRWARAATGRNTIVV
FNGCYHGTVDDVFVDLVDGRAVQRDSLLGQSYDLLANTRVVEFNDLDALEAALKHDDVACVIAEPAMTNIGMVLPEPGFW
REARALTRRYGTLLVIDETHTISSGPGGYAVAHDLEPDVLVVGKPIAGGVPCAVYGFSAEFAERAKQAKLNAPPGHSGIG
TTLTANMLAMHAMRATLAEVATDAAYAHMFELAARLAAGLEQTIAKHALPWCVTRIGARTEFQFAPTPPRNGTLAGAQLD
SELEHIVHLYLLNRGVLITPFHNMMLVCPQTTADDVDRLVAAFDACLSELT

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=299, Percent_Identity=23.7458193979933, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786349, Length=379, Percent_Identity=30.6068601583113, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI145693181, Length=239, Percent_Identity=28.4518828451883, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788044, Length=259, Percent_Identity=27.7992277992278, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789759, Length=252, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789016, Length=401, Percent_Identity=23.6907730673317, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25144271, Length=297, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144274, Length=142, Percent_Identity=32.3943661971831, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 49397; Mature: 49266

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRHGVDLTRARALFDRERRAFTEAMPISRALSAEAAEHLLFGVPLHWMQDWSTPFSLY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHEE
VKEARGATFTDVDGHRYVDFCLGDTGAMFGHAPEPVARALAEQATRGYTTMLPSEDAAWV
EECCCCCEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHH
SRELARRFRLPFWQFALSASDANRFVLRWARAATGRNTIVVFNGCYHGTVDDVFVDLVDG
HHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCC
RAVQRDSLLGQSYDLLANTRVVEFNDLDALEAALKHDDVACVIAEPAMTNIGMVLPEPGF
CCCCHHHHCCCCHHHHHCCEEEEECCHHHHHHHHCCCCEEEEEECCCHHHCCEECCCCCC
WREARALTRRYGTLLVIDETHTISSGPGGYAVAHDLEPDVLVVGKPIAGGVPCAVYGFSA
HHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEECCH
EFAERAKQAKLNAPPGHSGIGTTLTANMLAMHAMRATLAEVATDAAYAHMFELAARLAAG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQTIAKHALPWCVTRIGARTEFQFAPTPPRNGTLAGAQLDSELEHIVHLYLLNRGVLIT
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHCCCEEEE
PFHNMMLVCPQTTADDVDRLVAAFDACLSELT
ECCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSRHGVDLTRARALFDRERRAFTEAMPISRALSAEAAEHLLFGVPLHWMQDWSTPFSLY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHEE
VKEARGATFTDVDGHRYVDFCLGDTGAMFGHAPEPVARALAEQATRGYTTMLPSEDAAWV
EECCCCCEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHH
SRELARRFRLPFWQFALSASDANRFVLRWARAATGRNTIVVFNGCYHGTVDDVFVDLVDG
HHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCC
RAVQRDSLLGQSYDLLANTRVVEFNDLDALEAALKHDDVACVIAEPAMTNIGMVLPEPGF
CCCCHHHHCCCCHHHHHCCEEEEECCHHHHHHHHCCCCEEEEEECCCHHHCCEECCCCCC
WREARALTRRYGTLLVIDETHTISSGPGGYAVAHDLEPDVLVVGKPIAGGVPCAVYGFSA
HHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEECCH
EFAERAKQAKLNAPPGHSGIGTTLTANMLAMHAMRATLAEVATDAAYAHMFELAARLAAG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQTIAKHALPWCVTRIGARTEFQFAPTPPRNGTLAGAQLDSELEHIVHLYLLNRGVLIT
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHCCCEEEE
PFHNMMLVCPQTTADDVDRLVAAFDACLSELT
ECCCEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA