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The map label for this gene is pcaK [H]

Identifier: 189354029

GI number: 189354029

Start: 2357862

End: 2359208

Strand: Reverse

Name: pcaK [H]

Synonym: BMULJ_05282

Alternate gene names: 189354029

Gene position: 2359208-2357862 (Counterclockwise)

Preceding gene: 189354030

Following gene: 189354027

Centisome position: 95.39

GC content: 71.94

Gene sequence:

>1347_bases
ATGACGGCTTCCGCCACCCGCTCGATCCCCGCGTGGATCGACGATGCGCCGCTCGGCGCGTTCCAGATCCGTGTGCTCGC
GCTGTGCGTGCTGATCGCGCTGCTCGACGGCTTCGATACGCAGGCGATCGCGTTTACCGGCCCCGCGATTCTCGCGTCGT
TCGCGTTGCCGGCCGGCGCGCTCGCGCCGATCCTGACCGCGGGGATCGTCGGCATGACGATCGGCGCGATGACGCTCGGC
CTCGTCGGCGATCGCATCGGGCGCCGGCCCGCGATCATGATCGGGCTCGCGCTGTTCGGCGCGGCGACGCTCGCGACCGC
GTGGGCGAGCAGTCCGTCGCAGATTCTCGTCCTGCGTTTCATTGCCGGACTCGGGATGGGCGGCTGTACGCCGGTGCTGC
TCGCGCTCGCGGCCGAATACTGCCCCGCGCGGCTGCGCGGCGCCGTGATGACTGGCGTGCTGCTCGGGCTGCCCGCCGGC
GCGATGCTCGGCGGGCTGCTGGCCGCGCGGATGCTGCCGGCAATCGGCTGGCAGGGCATTTTCGTGGTGGGCGGCGGCGT
GCCGCTCGCGATGCTCGGCGCTGTCGCGCTGCTGCTGCCGGAATCGCTCTGCTATCTGGCGTCGCGCGACGATGCGCGTG
CACAGCAGCGCGTGCGGGCGACGCTGCCGAAAATCGCGACGCAGCCGCTGCCGGCCGACGCGCACTTCACGGTGCCCGAC
GAAGCAAGCGCGAAGGCGAGCGTCGGCGCCTTGTTCCGCAACGGCTACGCGCGCCGGACGCTCGGCATCTGGGCCATCTA
TCTGCTGAACTGGATCGCATGGTTCATGCTGCTGTCGTGGCTGCCGACCGTGCTGAAGGCGGCCGGCCTGACCGCGCAGC
AGGCGCCGGTCGGCACCGTGATCGTCAATGCGGTCTTCATCGTCTGCGCGATTCCGCTGTCGATCGTGCTGCCGCGCGTG
AACGTGCGCAACCTGCTGTGCGCGATGTTCGCGTTCGGTATCGCGGTGGCGCTCGCGCTCGGCCAGGCCGGCACGAACTG
GACGCTCGTGTTCGTGCTCGTCGGCGCGGCCGGCTTCGGGGTCGGCGGCCAGCAGATCGCGCTCAACTATCTGATCGTCG
GCGCGTATCCGACCGCGCTGCGCGCGACGGCAACGGGCTGGGCGATCGGAATGGGGCGTGCAGGCGCGATTGCCGGCTCG
GCGATCGGCGGCACGTTTCTCGCGTGGGGCGGTGCGCCCGGCTTCTTCACCGCGCTGGCGGTGCCGCTCGCCGGCGCCGC
GCTCGCCGCGTTCGGGCTGCGTCCCGGCCGCACGCCGGGCGCCGATCTCGCGGCGGCGAACCGCTGA

Upstream 100 bases:

>100_bases
GTGGCGGTGTTGTCGCGCTGAGTGCGCGGGCGGCGTTCGACCACGACAGACAAAAAACAACCGGGCCGTCGTCGCGCCCG
GACTCAGGAGACTTCCCTCG

Downstream 100 bases:

>100_bases
CGACGCGAACGGGCGTCGGCCCGTTCAGTCCGGCGCCGGCCCGCGCCGCGCCGTCGGTTCGTGCTCCGACGGCGTCATGT
ATTCCATGCCCTGCTCGTCG

Product: putative 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTASATRSIPAWIDDAPLGAFQIRVLALCVLIALLDGFDTQAIAFTGPAILASFALPAGALAPILTAGIVGMTIGAMTLG
LVGDRIGRRPAIMIGLALFGAATLATAWASSPSQILVLRFIAGLGMGGCTPVLLALAAEYCPARLRGAVMTGVLLGLPAG
AMLGGLLAARMLPAIGWQGIFVVGGGVPLAMLGAVALLLPESLCYLASRDDARAQQRVRATLPKIATQPLPADAHFTVPD
EASAKASVGALFRNGYARRTLGIWAIYLLNWIAWFMLLSWLPTVLKAAGLTAQQAPVGTVIVNAVFIVCAIPLSIVLPRV
NVRNLLCAMFAFGIAVALALGQAGTNWTLVFVLVGAAGFGVGGQQIALNYLIVGAYPTALRATATGWAIGMGRAGAIAGS
AIGGTFLAWGGAPGFFTALAVPLAGAALAAFGLRPGRTPGADLAAANR

Sequences:

>Translated_448_residues
MTASATRSIPAWIDDAPLGAFQIRVLALCVLIALLDGFDTQAIAFTGPAILASFALPAGALAPILTAGIVGMTIGAMTLG
LVGDRIGRRPAIMIGLALFGAATLATAWASSPSQILVLRFIAGLGMGGCTPVLLALAAEYCPARLRGAVMTGVLLGLPAG
AMLGGLLAARMLPAIGWQGIFVVGGGVPLAMLGAVALLLPESLCYLASRDDARAQQRVRATLPKIATQPLPADAHFTVPD
EASAKASVGALFRNGYARRTLGIWAIYLLNWIAWFMLLSWLPTVLKAAGLTAQQAPVGTVIVNAVFIVCAIPLSIVLPRV
NVRNLLCAMFAFGIAVALALGQAGTNWTLVFVLVGAAGFGVGGQQIALNYLIVGAYPTALRATATGWAIGMGRAGAIAGS
AIGGTFLAWGGAPGFFTALAVPLAGAALAAFGLRPGRTPGADLAAANR
>Mature_447_residues
TASATRSIPAWIDDAPLGAFQIRVLALCVLIALLDGFDTQAIAFTGPAILASFALPAGALAPILTAGIVGMTIGAMTLGL
VGDRIGRRPAIMIGLALFGAATLATAWASSPSQILVLRFIAGLGMGGCTPVLLALAAEYCPARLRGAVMTGVLLGLPAGA
MLGGLLAARMLPAIGWQGIFVVGGGVPLAMLGAVALLLPESLCYLASRDDARAQQRVRATLPKIATQPLPADAHFTVPDE
ASAKASVGALFRNGYARRTLGIWAIYLLNWIAWFMLLSWLPTVLKAAGLTAQQAPVGTVIVNAVFIVCAIPLSIVLPRVN
VRNLLCAMFAFGIAVALALGQAGTNWTLVFVLVGAAGFGVGGQQIALNYLIVGAYPTALRATATGWAIGMGRAGAIAGSA
IGGTFLAWGGAPGFFTALAVPLAGAALAAFGLRPGRTPGADLAAANR

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=413, Percent_Identity=25.4237288135593, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI213021148, Length=265, Percent_Identity=24.9056603773585, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081723, Length=421, Percent_Identity=29.9287410926366, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87082159, Length=401, Percent_Identity=24.9376558603491, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082231, Length=182, Percent_Identity=29.6703296703297, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788068, Length=457, Percent_Identity=23.4135667396061, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=22.5888324873096, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994889, Length=162, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788074, Length=239, Percent_Identity=27.1966527196653, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640198, Length=451, Percent_Identity=24.1685144124169, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640196, Length=451, Percent_Identity=24.1685144124169, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640200, Length=451, Percent_Identity=24.1685144124169, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45469; Mature: 45337

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASATRSIPAWIDDAPLGAFQIRVLALCVLIALLDGFDTQAIAFTGPAILASFALPAGA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCHH
LAPILTAGIVGMTIGAMTLGLVGDRIGRRPAIMIGLALFGAATLATAWASSPSQILVLRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAGLGMGGCTPVLLALAAEYCPARLRGAVMTGVLLGLPAGAMLGGLLAARMLPAIGWQGI
HHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
FVVGGGVPLAMLGAVALLLPESLCYLASRDDARAQQRVRATLPKIATQPLPADAHFTVPD
EEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
EASAKASVGALFRNGYARRTLGIWAIYLLNWIAWFMLLSWLPTVLKAAGLTAQQAPVGTV
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IVNAVFIVCAIPLSIVLPRVNVRNLLCAMFAFGIAVALALGQAGTNWTLVFVLVGAAGFG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHEEEHHHCCC
VGGQQIALNYLIVGAYPTALRATATGWAIGMGRAGAIAGSAIGGTFLAWGGAPGFFTALA
CCCHHEEEEEEEEECCCHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VPLAGAALAAFGLRPGRTPGADLAAANR
HHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TASATRSIPAWIDDAPLGAFQIRVLALCVLIALLDGFDTQAIAFTGPAILASFALPAGA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCHH
LAPILTAGIVGMTIGAMTLGLVGDRIGRRPAIMIGLALFGAATLATAWASSPSQILVLRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IAGLGMGGCTPVLLALAAEYCPARLRGAVMTGVLLGLPAGAMLGGLLAARMLPAIGWQGI
HHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
FVVGGGVPLAMLGAVALLLPESLCYLASRDDARAQQRVRATLPKIATQPLPADAHFTVPD
EEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
EASAKASVGALFRNGYARRTLGIWAIYLLNWIAWFMLLSWLPTVLKAAGLTAQQAPVGTV
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IVNAVFIVCAIPLSIVLPRVNVRNLLCAMFAFGIAVALALGQAGTNWTLVFVLVGAAGFG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHEEEHHHCCC
VGGQQIALNYLIVGAYPTALRATATGWAIGMGRAGAIAGSAIGGTFLAWGGAPGFFTALA
CCCHHEEEEEEEEECCCHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VPLAGAALAAFGLRPGRTPGADLAAANR
HHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]