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The map label for this gene is zwf [H]

Identifier: 189353920

GI number: 189353920

Start: 2234262

End: 2235737

Strand: Direct

Name: zwf [H]

Synonym: BMULJ_05172

Alternate gene names: 189353920

Gene position: 2234262-2235737 (Clockwise)

Preceding gene: 189353919

Following gene: 189353922

Centisome position: 90.34

GC content: 67.07

Gene sequence:

>1476_bases
ATGACGAATCAGCCTACTCAGACCGCAGCCGACCGGCCCGTCGACATGATCATCTTCGGCGGCGGCGGCGACCTGGCCGC
CCGCAAGCTGCTGCCCGCGCTGTACATGGCGCACCTGCACCGCAACCTTCCGCCCGACACGCGCATCATCGCGGTCGGCC
GCCGCGACTGGGGCATCGACGGCTACCGCAAGTTCATGGACGAGCAGTCGCGCCCGTTCATCGACGAGAAGGCGTTCGAC
GCCGACGCGTGGCGCCGCTTCCTCGACCTGTTCCAGTACGTGCTGATCGACGTGAACGCGCCCGACGACTATGCGCGGCT
CGCGGCCGCGTCGCGCGACGGCGCGATCCGCGTGTTCTACCTGTCGACGTCGCCGGAGCTGTTCACGACGATCTGCGACA
ACCTGTCGGCCGCGCATCTCGTCGATGCGCATTCGCGCGTCGTGCTCGAAAAGCCGCTCGGTCACGATCTCGCGTCGGCG
AAGGCGATCAACGATTCGGTCGGCAAGCATTTCGAGGAATCGCAGATCTACCGGATCGACCACTATCTGGGCAAGGAAAC
GGTGCAGAACCTGATGGTGCTGCGCTTCGGCAATCCGATCTTCGGGCCGCTGTGGCAGGCGCCGAGCATCCGCAGCGTGC
AGATCACGGTCGCGGAGACGGTCGGCGTCGGCAGCCGCGCGGGCTTCTACGACCATACGGGCGCGCTGCGCGACATGGTG
CAGAACCACCTGCTACAGCTGCTCTGCATCGTCGCGATGGAGCCGCCCGTGTCGCTCGACCCGGACGCCGTGCGCGACGA
GAAGCTGAAGGTGCTGCGCTCGCTGCGGCCGATGTCGCTGTCGGATGTCGCGCGCGACACGGTGCGCGGCCAGTACACGG
CCGGCGCCGTCGACGGCCAGCCGGTCAAGGGCTACCTCGAGGAAGAGAACGTGCCGCCGGACAGCCGCGCGGAAACCTTC
GTCGCGCTGCGCGCGTATATCAACAACTGGCGCTGGGCGAACGTGCCGTTCTTCCTGCGCACCGGCAAGCGGCTGCAGCG
GCGTCAGTCGGAAATCGTGATCGAGTTCGCCGACATGCCGTTTTCGATCATCCCGAGCGGCCCGCGCCACTACGGCAACC
GCCTCGTGATCCAGCTCCAGCCGGAGGAATCGATCCAGCTGCAAATGCTCGCGAAGGAGCCGGGCAGCGGCATGAACATG
GTGCCGGTAAGCCTGAACCTCGATCTGCAGCAGGCGATTCCCGAGCGTCGCGCGGAAGCGTACGAGCGGCTGCTGATCGA
CGTGATTCGCGGACGCCTCACGCACTTCATGCGCCGCGACGAGCTCGAAGCCGCGTGGACCTGGGTCGAGCCGATTCTCG
ACGGCTGGCAACAGCTCGGCGACCGGCCGCGGCTCTATACGGCCGGCACGTTCGGGCCTGCCGCGTCGTCGGCGCTGCTC
GCGCGCGACAACATGTCGTGGTCGGAAGAAGCGTGA

Upstream 100 bases:

>100_bases
CGTGCACTATTAGCACTTCGCCGCACCGACGCTGGACGCTTCGGCGCCCGGCCGTTTCGACGTCCGTTTCACGTTCCCCG
TTTCAGACCGCGAACCACCC

Downstream 100 bases:

>100_bases
CGCGGCACGCGGCCGAGCCGGCGCGCGACGTGCGTCGCGACCGGCGGGCCGCTACGACGGGCTCAACCATGCGGCCTTGC
GCCGCGACGGCGCGCTGCCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTNQPTQTAADRPVDMIIFGGGGDLAARKLLPALYMAHLHRNLPPDTRIIAVGRRDWGIDGYRKFMDEQSRPFIDEKAFD
ADAWRRFLDLFQYVLIDVNAPDDYARLAAASRDGAIRVFYLSTSPELFTTICDNLSAAHLVDAHSRVVLEKPLGHDLASA
KAINDSVGKHFEESQIYRIDHYLGKETVQNLMVLRFGNPIFGPLWQAPSIRSVQITVAETVGVGSRAGFYDHTGALRDMV
QNHLLQLLCIVAMEPPVSLDPDAVRDEKLKVLRSLRPMSLSDVARDTVRGQYTAGAVDGQPVKGYLEEENVPPDSRAETF
VALRAYINNWRWANVPFFLRTGKRLQRRQSEIVIEFADMPFSIIPSGPRHYGNRLVIQLQPEESIQLQMLAKEPGSGMNM
VPVSLNLDLQQAIPERRAEAYERLLIDVIRGRLTHFMRRDELEAAWTWVEPILDGWQQLGDRPRLYTAGTFGPAASSALL
ARDNMSWSEEA

Sequences:

>Translated_491_residues
MTNQPTQTAADRPVDMIIFGGGGDLAARKLLPALYMAHLHRNLPPDTRIIAVGRRDWGIDGYRKFMDEQSRPFIDEKAFD
ADAWRRFLDLFQYVLIDVNAPDDYARLAAASRDGAIRVFYLSTSPELFTTICDNLSAAHLVDAHSRVVLEKPLGHDLASA
KAINDSVGKHFEESQIYRIDHYLGKETVQNLMVLRFGNPIFGPLWQAPSIRSVQITVAETVGVGSRAGFYDHTGALRDMV
QNHLLQLLCIVAMEPPVSLDPDAVRDEKLKVLRSLRPMSLSDVARDTVRGQYTAGAVDGQPVKGYLEEENVPPDSRAETF
VALRAYINNWRWANVPFFLRTGKRLQRRQSEIVIEFADMPFSIIPSGPRHYGNRLVIQLQPEESIQLQMLAKEPGSGMNM
VPVSLNLDLQQAIPERRAEAYERLLIDVIRGRLTHFMRRDELEAAWTWVEPILDGWQQLGDRPRLYTAGTFGPAASSALL
ARDNMSWSEEA
>Mature_490_residues
TNQPTQTAADRPVDMIIFGGGGDLAARKLLPALYMAHLHRNLPPDTRIIAVGRRDWGIDGYRKFMDEQSRPFIDEKAFDA
DAWRRFLDLFQYVLIDVNAPDDYARLAAASRDGAIRVFYLSTSPELFTTICDNLSAAHLVDAHSRVVLEKPLGHDLASAK
AINDSVGKHFEESQIYRIDHYLGKETVQNLMVLRFGNPIFGPLWQAPSIRSVQITVAETVGVGSRAGFYDHTGALRDMVQ
NHLLQLLCIVAMEPPVSLDPDAVRDEKLKVLRSLRPMSLSDVARDTVRGQYTAGAVDGQPVKGYLEEENVPPDSRAETFV
ALRAYINNWRWANVPFFLRTGKRLQRRQSEIVIEFADMPFSIIPSGPRHYGNRLVIQLQPEESIQLQMLAKEPGSGMNMV
PVSLNLDLQQAIPERRAEAYERLLIDVIRGRLTHFMRRDELEAAWTWVEPILDGWQQLGDRPRLYTAGTFGPAASSALLA
RDNMSWSEEA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=477, Percent_Identity=37.3165618448637, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI109389365, Length=477, Percent_Identity=37.3165618448637, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI52145310, Length=500, Percent_Identity=29, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=47.0347648261759, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=36.9072164948454, Blast_Score=325, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=34.297520661157, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24643352, Length=497, Percent_Identity=36.0160965794769, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24643350, Length=497, Percent_Identity=36.0160965794769, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=29.8387096774194, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55319; Mature: 55188

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQPTQTAADRPVDMIIFGGGGDLAARKLLPALYMAHLHRNLPPDTRIIAVGRRDWGID
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCH
GYRKFMDEQSRPFIDEKAFDADAWRRFLDLFQYVLIDVNAPDDYARLAAASRDGAIRVFY
HHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCCEEEEE
LSTSPELFTTICDNLSAAHLVDAHSRVVLEKPLGHDLASAKAINDSVGKHFEESQIYRID
ECCCCHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEHHH
HYLGKETVQNLMVLRFGNPIFGPLWQAPSIRSVQITVAETVGVGSRAGFYDHTGALRDMV
HHHCHHHHHHHEEHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
QNHLLQLLCIVAMEPPVSLDPDAVRDEKLKVLRSLRPMSLSDVARDTVRGQYTAGAVDGQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCC
PVKGYLEEENVPPDSRAETFVALRAYINNWRWANVPFFLRTGKRLQRRQSEIVIEFADMP
CCCCHHCCCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHCCHHHHHHHHHEEEEECCCC
FSIIPSGPRHYGNRLVIQLQPEESIQLQMLAKEPGSGMNMVPVSLNLDLQQAIPERRAEA
EEECCCCCHHCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHH
YERLLIDVIRGRLTHFMRRDELEAAWTWVEPILDGWQQLGDRPRLYTAGTFGPAASSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCHHE
ARDNMSWSEEA
EECCCCCCCCC
>Mature Secondary Structure 
TNQPTQTAADRPVDMIIFGGGGDLAARKLLPALYMAHLHRNLPPDTRIIAVGRRDWGID
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCH
GYRKFMDEQSRPFIDEKAFDADAWRRFLDLFQYVLIDVNAPDDYARLAAASRDGAIRVFY
HHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCCCCCEEEEE
LSTSPELFTTICDNLSAAHLVDAHSRVVLEKPLGHDLASAKAINDSVGKHFEESQIYRID
ECCCCHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEHHH
HYLGKETVQNLMVLRFGNPIFGPLWQAPSIRSVQITVAETVGVGSRAGFYDHTGALRDMV
HHHCHHHHHHHEEHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
QNHLLQLLCIVAMEPPVSLDPDAVRDEKLKVLRSLRPMSLSDVARDTVRGQYTAGAVDGQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCC
PVKGYLEEENVPPDSRAETFVALRAYINNWRWANVPFFLRTGKRLQRRQSEIVIEFADMP
CCCCHHCCCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHCCHHHHHHHHHEEEEECCCC
FSIIPSGPRHYGNRLVIQLQPEESIQLQMLAKEPGSGMNMVPVSLNLDLQQAIPERRAEA
EEECCCCCHHCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHH
YERLLIDVIRGRLTHFMRRDELEAAWTWVEPILDGWQQLGDRPRLYTAGTFGPAASSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCHHE
ARDNMSWSEEA
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA