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The map label for this gene is lysP [H]

Identifier: 189353819

GI number: 189353819

Start: 2119293

End: 2120873

Strand: Direct

Name: lysP [H]

Synonym: BMULJ_05066

Alternate gene names: 189353819

Gene position: 2119293-2120873 (Clockwise)

Preceding gene: 189353817

Following gene: 189353820

Centisome position: 85.69

GC content: 66.54

Gene sequence:

>1581_bases
ATGCACTCAGATGCCCGCCCCGATTCGTCCCGTCCGCCCGGTTCGCGCGCCGCGAAGCCGGCCCTCCATCGCCGCCTGCA
GGCGCGCCATCTGCGGATGATCGCGATCGGCGGCTCGATCGGCACGGGCCTGTTCGTCGCATCCGGCGCGTCGATCTCGC
AGGCCGGCCCCGGCGGCGCGATGTTCGCGTACATGGTGATCGGGCTGATGGTGTACTTCCTGATGACGAGCCTCGGCGAA
ATGGCCGCATTCATGCCGGTGTCGGGCTCGTTCGCGACCTACGGCGCGAAGTTCGTCGACGAAGGCTTCGGCTTCGCGCT
CGGCTGGAACTACTGGTACAGCTGGGCCGTCACGCTCGCGGTCGAACTGGTCGCCGCGCAGCTCGTGATGCACTACTGGT
TTCCGCACGTACCGGGCGTCTGGTGGAGCGCGCTCTTTCTGACGCTGATCTTCGCGCTCAACGCGCTGTCGGTGCGCGGC
TTCGGCGAGGCCGAATACTGGTTCGCGCTGGTCAAGGTGCTGACCGTGATCGCGTTTCTCGGCGTCGGCCTGCTGATGAT
CTTCGGCATCATGAAGGGCGGCCCGAGCGCGGGCCTCGCGAACTTCACGATCGGCGACGCGCCGTTCGTCGGCGGCCTGC
CGGCGATGCTCGGCGTCGCGATGATCGCCGGCTTCTCGTTCCAGGGCACCGAAATGATCGGTGTCGCGGCCGGCGAATCG
GAAAACCCGCGCACGACGATCCCGCGGGCGGTCAGCCAGATCTTCTGGCGCATCCTGCTGTTCTACGTACTCGCGATCTT
CGTGATCGGCGTGCTGATTCCGTACACCGACCCGAGCCTGCTGAAGACCGACGTGACCGACATCGGCGTGAGCCCGTTCA
CGCTCGTGTTCCGTCACGCGGGCCTTGCGTTTGCGGCCGGCGTGATGAACGCCGTGATCCTGACGGCGGTGCTGTCGGCC
GGTAATTCCGGCATGTATGCATCGACGCGCATGCTGTACAACCTCGCCACCGAAGGCCGCGCGCCGAAGCTGTTCGCGAA
GCTGTCGCCGGGCGGCGTGCCGCGCAATGCGCTCTACGCGACGACGGCCGTCGGCGCGCTCTGTTTCCTGACCTCGCTGT
ATGGCGACAAGACCGTCTACATGTGGCTGCTCAACACGTCGGGCATGGCAGGCTTCATCACGTGGCTCGGGATTGCCGTC
AGCCACTACCGCTTCCGCAAGGGACTGCTGAAGCAGGGTTACCGTCTCGATCAGCTGCCGTACCGGTCGAAGTGGTTCCC
GTTCGGCCCGATCTTCGCGTTCGTGCTGTGCGCGATCGTCGCGCTCGGGCAGGACTACCAGGCGTTCTTCGCGGCGCGGA
TCGACTGGGTCGCCGTTGCCGCGACCTATATCGGGCTGCCGTTCTTCTTCGCGATCTGGATCGGCTACGCGCTGGTGCGC
AAATGCCGGCTCGTCCGCTACGAGGACATGGACATCGCCCCGTGGATCGAGCGCAACGCAACGCCGGAGCCGGCCACCGA
CACCTCGGCCGGCTACGCCGCCTACGTCGCACGGCCTGCGAACCCGACGTCCGGCGCATAA

Upstream 100 bases:

>100_bases
ACGGCGAACGAAGGCGACGCGCGCCGCCGCGCGATCCGCGCGGACACACGGCCGCGTCGCATCGACAACAAAATTCCGGA
GACAGCGCCCAGCGCCCGCC

Downstream 100 bases:

>100_bases
GCGCGCCGCCGCCGCGCCGCGCCGCGCGCCGAGCCAGCGCGCGACCGGCGCCACCCGAACACCATTCGACGCGGCGCGCG
CGTTCAGGCAAGATCGACGC

Product: AAT family amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MHSDARPDSSRPPGSRAAKPALHRRLQARHLRMIAIGGSIGTGLFVASGASISQAGPGGAMFAYMVIGLMVYFLMTSLGE
MAAFMPVSGSFATYGAKFVDEGFGFALGWNYWYSWAVTLAVELVAAQLVMHYWFPHVPGVWWSALFLTLIFALNALSVRG
FGEAEYWFALVKVLTVIAFLGVGLLMIFGIMKGGPSAGLANFTIGDAPFVGGLPAMLGVAMIAGFSFQGTEMIGVAAGES
ENPRTTIPRAVSQIFWRILLFYVLAIFVIGVLIPYTDPSLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSA
GNSGMYASTRMLYNLATEGRAPKLFAKLSPGGVPRNALYATTAVGALCFLTSLYGDKTVYMWLLNTSGMAGFITWLGIAV
SHYRFRKGLLKQGYRLDQLPYRSKWFPFGPIFAFVLCAIVALGQDYQAFFAARIDWVAVAATYIGLPFFFAIWIGYALVR
KCRLVRYEDMDIAPWIERNATPEPATDTSAGYAAYVARPANPTSGA

Sequences:

>Translated_526_residues
MHSDARPDSSRPPGSRAAKPALHRRLQARHLRMIAIGGSIGTGLFVASGASISQAGPGGAMFAYMVIGLMVYFLMTSLGE
MAAFMPVSGSFATYGAKFVDEGFGFALGWNYWYSWAVTLAVELVAAQLVMHYWFPHVPGVWWSALFLTLIFALNALSVRG
FGEAEYWFALVKVLTVIAFLGVGLLMIFGIMKGGPSAGLANFTIGDAPFVGGLPAMLGVAMIAGFSFQGTEMIGVAAGES
ENPRTTIPRAVSQIFWRILLFYVLAIFVIGVLIPYTDPSLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSA
GNSGMYASTRMLYNLATEGRAPKLFAKLSPGGVPRNALYATTAVGALCFLTSLYGDKTVYMWLLNTSGMAGFITWLGIAV
SHYRFRKGLLKQGYRLDQLPYRSKWFPFGPIFAFVLCAIVALGQDYQAFFAARIDWVAVAATYIGLPFFFAIWIGYALVR
KCRLVRYEDMDIAPWIERNATPEPATDTSAGYAAYVARPANPTSGA
>Mature_526_residues
MHSDARPDSSRPPGSRAAKPALHRRLQARHLRMIAIGGSIGTGLFVASGASISQAGPGGAMFAYMVIGLMVYFLMTSLGE
MAAFMPVSGSFATYGAKFVDEGFGFALGWNYWYSWAVTLAVELVAAQLVMHYWFPHVPGVWWSALFLTLIFALNALSVRG
FGEAEYWFALVKVLTVIAFLGVGLLMIFGIMKGGPSAGLANFTIGDAPFVGGLPAMLGVAMIAGFSFQGTEMIGVAAGES
ENPRTTIPRAVSQIFWRILLFYVLAIFVIGVLIPYTDPSLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSA
GNSGMYASTRMLYNLATEGRAPKLFAKLSPGGVPRNALYATTAVGALCFLTSLYGDKTVYMWLLNTSGMAGFITWLGIAV
SHYRFRKGLLKQGYRLDQLPYRSKWFPFGPIFAFVLCAIVALGQDYQAFFAARIDWVAVAATYIGLPFFFAIWIGYALVR
KCRLVRYEDMDIAPWIERNATPEPATDTSAGYAAYVARPANPTSGA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=472, Percent_Identity=72.2457627118644, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=476, Percent_Identity=40.546218487395, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1786789, Length=424, Percent_Identity=36.7924528301887, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI48994972, Length=454, Percent_Identity=37.2246696035242, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1786302, Length=392, Percent_Identity=36.734693877551, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=34.9489795918367, Blast_Score=239, Evalue=5e-64,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=35.7142857142857, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1790653, Length=398, Percent_Identity=35.678391959799, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1786602, Length=394, Percent_Identity=35.7868020304569, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081869, Length=409, Percent_Identity=23.2273838630807, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=484, Percent_Identity=37.1900826446281, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6324061, Length=504, Percent_Identity=36.3095238095238, Blast_Score=337, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6324059, Length=525, Percent_Identity=34.8571428571429, Blast_Score=312, Evalue=8e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=510, Percent_Identity=32.7450980392157, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6322892, Length=506, Percent_Identity=34.9802371541502, Blast_Score=292, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6321629, Length=482, Percent_Identity=32.3651452282158, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6324553, Length=442, Percent_Identity=35.7466063348416, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=31.4, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322967, Length=475, Percent_Identity=33.0526315789474, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319824, Length=502, Percent_Identity=28.8844621513944, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6320717, Length=483, Percent_Identity=28.5714285714286, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6324981, Length=453, Percent_Identity=33.3333333333333, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6320251, Length=493, Percent_Identity=27.9918864097363, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6319542, Length=480, Percent_Identity=27.7083333333333, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6321053, Length=483, Percent_Identity=31.055900621118, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=504, Percent_Identity=28.5714285714286, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6319608, Length=503, Percent_Identity=27.4353876739563, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=554, Percent_Identity=26.8953068592058, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56836; Mature: 56836

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSDARPDSSRPPGSRAAKPALHRRLQARHLRMIAIGGSIGTGLFVASGASISQAGPGGA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCCCHH
MFAYMVIGLMVYFLMTSLGEMAAFMPVSGSFATYGAKFVDEGFGFALGWNYWYSWAVTLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
VELVAAQLVMHYWFPHVPGVWWSALFLTLIFALNALSVRGFGEAEYWFALVKVLTVIAFL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GVGLLMIFGIMKGGPSAGLANFTIGDAPFVGGLPAMLGVAMIAGFSFQGTEMIGVAAGES
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
ENPRTTIPRAVSQIFWRILLFYVLAIFVIGVLIPYTDPSLLKTDVTDIGVSPFTLVFRHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHCCCCHHHHHHHHH
GLAFAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPKLFAKLSPGGVPRNALYA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TTAVGALCFLTSLYGDKTVYMWLLNTSGMAGFITWLGIAVSHYRFRKGLLKQGYRLDQLP
HHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YRSKWFPFGPIFAFVLCAIVALGQDYQAFFAARIDWVAVAATYIGLPFFFAIWIGYALVR
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCRLVRYEDMDIAPWIERNATPEPATDTSAGYAAYVARPANPTSGA
HHHHHEECCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MHSDARPDSSRPPGSRAAKPALHRRLQARHLRMIAIGGSIGTGLFVASGASISQAGPGGA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCCCHH
MFAYMVIGLMVYFLMTSLGEMAAFMPVSGSFATYGAKFVDEGFGFALGWNYWYSWAVTLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
VELVAAQLVMHYWFPHVPGVWWSALFLTLIFALNALSVRGFGEAEYWFALVKVLTVIAFL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GVGLLMIFGIMKGGPSAGLANFTIGDAPFVGGLPAMLGVAMIAGFSFQGTEMIGVAAGES
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
ENPRTTIPRAVSQIFWRILLFYVLAIFVIGVLIPYTDPSLLKTDVTDIGVSPFTLVFRHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHCCCCHHHHHHHHH
GLAFAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPKLFAKLSPGGVPRNALYA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TTAVGALCFLTSLYGDKTVYMWLLNTSGMAGFITWLGIAVSHYRFRKGLLKQGYRLDQLP
HHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YRSKWFPFGPIFAFVLCAIVALGQDYQAFFAARIDWVAVAATYIGLPFFFAIWIGYALVR
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCRLVRYEDMDIAPWIERNATPEPATDTSAGYAAYVARPANPTSGA
HHHHHEECCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]