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The map label for this gene is mmsB [H]

Identifier: 189353770

GI number: 189353770

Start: 2051577

End: 2052467

Strand: Direct

Name: mmsB [H]

Synonym: BMULJ_05017

Alternate gene names: 189353770

Gene position: 2051577-2052467 (Clockwise)

Preceding gene: 189353769

Following gene: 189353771

Centisome position: 82.95

GC content: 69.81

Gene sequence:

>891_bases
ATGTCACGAAATGTTGGAGTCATCGGCCTCGGTGCGATGGGCCTCGGCGTCGCGCGTTCGCTGCTGCGCGCGGGCTTTCG
CGTGCACGCATGCGACGTCCGTGAAGCCGTGCTGCACGCGTTCGCGGCCGAAGGCGGCATCGCCTGCGCGACGCCGGCAG
AACTCGGCGCGCAGTGCGACGTCGTCGTCACGCTCGTCGTCAATGCCGCGCAGACGGAAACGGTGCTGTTCGGCGAACAC
GGCGCGGTCGCGTCGATGAAGCCGGGCGGCGTCGTGATCGCGAGCGCGACCGTCGCGCCCGACTTCGCGGTCTCGCTCGG
CGCGCGCATCGAGGCCGCCGGCCTGCAGATGCTCGACGCGCCGGTGTCGGGCGGCGCCGCGCGCGCGGCGTCCGGCGAGA
TGACGATGATGACGTCCGGCCCCGCCGCCGCCTACGCCGCGTGCGAAGACGTGCTCGCCGCGATGGCGGGCAAGGTCTAC
CGTCTCGGCGATACGCACGGTGTCGGCTCGAAGGTCAAGATCATCAACCAGCTGCTGGCCGGCGTGCATATCGCGGCCGC
CGCCGAAGCGATGGCGCTCGGCCTGCGCGAAGGCGTCGATCCCGATGCGCTGTACGACGTGATCACGCACAGTGCCGGCA
ATTCGTGGATGTTCGAGAACCGCGTGCCGCACATCCTGAACGGCGACTACACGCCGCTGTCAGCCGTCGACATCTTCGTG
AAGGATCTCGGCCTCGTGCTCGACACCGCGCGCCGCAGCAAATTCCCGCTGCCGCTGTCGGCCGCCGCGCACCAGATGTT
CATGAGCGCGTCGAGCGCTGGCCACGGCGGCGAGGACGATTCCGCCGTGATCAAGACTTTCCCCGGCATCACGCTGCCGG
CCGCCCGCTGA

Upstream 100 bases:

>100_bases
GCACGCACATGTACAACGCGGCGCGCCGTCTCGCGGAAGCCGGCATCTGCTGACGCCGCGGCGCATTTCCGAATCCGTTC
CGAATCGATCAAGGTTGACC

Downstream 100 bases:

>100_bases
TTCGAACCACGTCTTGCCATGACCGCTTCCGCTTCCCGTCCCCTGCTCGGCTGCATCGCCGACGATTTCACCGGCGCGAC
CGATCTCGCGAACATGCTCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREAVLHAFAAEGGIACATPAELGAQCDVVVTLVVNAAQTETVLFGEH
GAVASMKPGGVVIASATVAPDFAVSLGARIEAAGLQMLDAPVSGGAARAASGEMTMMTSGPAAAYAACEDVLAAMAGKVY
RLGDTHGVGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
KDLGLVLDTARRSKFPLPLSAAAHQMFMSASSAGHGGEDDSAVIKTFPGITLPAAR

Sequences:

>Translated_296_residues
MSRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREAVLHAFAAEGGIACATPAELGAQCDVVVTLVVNAAQTETVLFGEH
GAVASMKPGGVVIASATVAPDFAVSLGARIEAAGLQMLDAPVSGGAARAASGEMTMMTSGPAAAYAACEDVLAAMAGKVY
RLGDTHGVGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
KDLGLVLDTARRSKFPLPLSAAAHQMFMSASSAGHGGEDDSAVIKTFPGITLPAAR
>Mature_295_residues
SRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREAVLHAFAAEGGIACATPAELGAQCDVVVTLVVNAAQTETVLFGEHG
AVASMKPGGVVIASATVAPDFAVSLGARIEAAGLQMLDAPVSGGAARAASGEMTMMTSGPAAAYAACEDVLAAMAGKVYR
LGDTHGVGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVK
DLGLVLDTARRSKFPLPLSAAAHQMFMSASSAGHGGEDDSAVIKTFPGITLPAAR

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=31.5972222222222, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=26.3157894736842, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1789092, Length=305, Percent_Identity=54.0983606557377, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=33.5714285714286, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=31.4487632508834, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=26.5957446808511, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=272, Percent_Identity=32.7205882352941, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=24.6478873239437, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 30045; Mature: 29914

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREAVLHAFAAEGGIACATPAELGAQCD
CCCCCCEEEECHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCEEECCHHHHCCCCE
VVVTLVVNAAQTETVLFGEHGAVASMKPGGVVIASATVAPDFAVSLGARIEAAGLQMLDA
EEEEEEECCCCCEEEEEECCCCEEECCCCCEEEEEEECCCCHHHHHCCEEECCCCEEECC
PVSGGAARAASGEMTMMTSGPAAAYAACEDVLAAMAGKVYRLGDTHGVGSKVKIINQLLA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
GVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCHHCCCCCCCHHHHHHHH
KDLGLVLDTARRSKFPLPLSAAAHQMFMSASSAGHGGEDDSAVIKTFPGITLPAAR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREAVLHAFAAEGGIACATPAELGAQCD
CCCCCEEEECHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCEEECCHHHHCCCCE
VVVTLVVNAAQTETVLFGEHGAVASMKPGGVVIASATVAPDFAVSLGARIEAAGLQMLDA
EEEEEEECCCCCEEEEEECCCCEEECCCCCEEEEEEECCCCHHHHHCCEEECCCCEEECC
PVSGGAARAASGEMTMMTSGPAAAYAACEDVLAAMAGKVYRLGDTHGVGSKVKIINQLLA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
GVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCHHCCCCCCCHHHHHHHH
KDLGLVLDTARRSKFPLPLSAAAHQMFMSASSAGHGGEDDSAVIKTFPGITLPAAR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]