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The map label for this gene is mmgB [H]

Identifier: 189353510

GI number: 189353510

Start: 1732477

End: 1733484

Strand: Direct

Name: mmgB [H]

Synonym: BMULJ_04754

Alternate gene names: 189353510

Gene position: 1732477-1733484 (Clockwise)

Preceding gene: 189353509

Following gene: 189353511

Centisome position: 70.05

GC content: 69.94

Gene sequence:

>1008_bases
ATGCCGCCCGTCGATCGTCGCGAAGCCGGCTCGCGCCATCCACGCGCCGGACAGCCGTCCGCTATCGGGCGCGCCGGCAT
CGTCGGCGCGGGTAGCATCGGCGTCGCCTTCGCGCTGGTGTTCGCGCGCGCAGGCTGGCGCGTGCGGCTGTTCGATCCCG
ATCCGGCGCGACGCGCGGCGGCGCCGGCCGAAATCGCGGCGCGCCTGGCCGACCTCGCGCACTTCGCATTGCTCGACGAA
AGCGCGGACTACATCGCGGCGCGCATCGAACTCGTCGAATCGATCGAAGCCGCCGCAGCCGATGCCGATCTCGTACAGGA
ATGCGCGCCCGAGCGCGTCGAACTCAAGCGCGCGCTGTTCGCGCAGCTCGACCGCGCCGCCCCTGCGCACGCGATTCTCG
CGAGCGCATCGTCGTTTCTCTGCGCGTCGGCGTTCGTCGACGAAACCGTTACGGGCCGCGCGCGCTGCCTCGTCGCGCAT
CCGGGCAATCCGCCGTACCTGATACCCGTGATCGAGATCGTGCCCGCCCCCTTTACGGCCGAGCACACCACCGCACGCGC
GATTGTGCTCTACGAAGCAGCGGGACTGAAGCCCGTTCGCGTGAAGAAGGAAATCGCCGGCTTCATCTTCAACCGACTGC
AAGGTGCGGTGTTGCGCGAAGCGTATTGCCTCGTGCGCGACGGCGTCGCGTCGGTCGACGATATCGATACGGTCATGCGC
GACGGGCTCGCGCCGCGCTGGTCGGTGACCGGCCCGTTCGAGACGGTCGACCTGAACACGCGCGGCGGCATCGCGTCGCA
TGCGCAAAAGATGGGGCCGTCCTACGAACGCTTGGGCGCCGAGCGCGGCCAGTCCGACCCTTGGACGCCCGAACTCGTCG
CCCACGTGACGGCCGCGCGGCGTGCGGCGTTGCCACTCGATCAATGGGACGCGCGCGTCGCATGGCGCGACCGTCGGCTC
ATGCAGCTCGCGCGGCATCGCAGGCTCGCCGCACCCGACGACGACTGA

Upstream 100 bases:

>100_bases
ACGCCGCGTCGTATCTGCTCGACGCGCGCAGCGGCTTCATCACCGGGCAGGTACTGTATGTATGCGGCGGCATGACCGTC
GGCGTCGCGGGTATCTGACG

Downstream 100 bases:

>100_bases
TCGCCCGGACGCCACCGGGGAATCGCAGAACAATCACGACACAACGGAGACAAAACCATGCAGAGATTGACCGCCTTCTT
CACCGAGCTGATGCGCCGGT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPPVDRREAGSRHPRAGQPSAIGRAGIVGAGSIGVAFALVFARAGWRVRLFDPDPARRAAAPAEIAARLADLAHFALLDE
SADYIAARIELVESIEAAAADADLVQECAPERVELKRALFAQLDRAAPAHAILASASSFLCASAFVDETVTGRARCLVAH
PGNPPYLIPVIEIVPAPFTAEHTTARAIVLYEAAGLKPVRVKKEIAGFIFNRLQGAVLREAYCLVRDGVASVDDIDTVMR
DGLAPRWSVTGPFETVDLNTRGGIASHAQKMGPSYERLGAERGQSDPWTPELVAHVTAARRAALPLDQWDARVAWRDRRL
MQLARHRRLAAPDDD

Sequences:

>Translated_335_residues
MPPVDRREAGSRHPRAGQPSAIGRAGIVGAGSIGVAFALVFARAGWRVRLFDPDPARRAAAPAEIAARLADLAHFALLDE
SADYIAARIELVESIEAAAADADLVQECAPERVELKRALFAQLDRAAPAHAILASASSFLCASAFVDETVTGRARCLVAH
PGNPPYLIPVIEIVPAPFTAEHTTARAIVLYEAAGLKPVRVKKEIAGFIFNRLQGAVLREAYCLVRDGVASVDDIDTVMR
DGLAPRWSVTGPFETVDLNTRGGIASHAQKMGPSYERLGAERGQSDPWTPELVAHVTAARRAALPLDQWDARVAWRDRRL
MQLARHRRLAAPDDD
>Mature_334_residues
PPVDRREAGSRHPRAGQPSAIGRAGIVGAGSIGVAFALVFARAGWRVRLFDPDPARRAAAPAEIAARLADLAHFALLDES
ADYIAARIELVESIEAAAADADLVQECAPERVELKRALFAQLDRAAPAHAILASASSFLCASAFVDETVTGRARCLVAHP
GNPPYLIPVIEIVPAPFTAEHTTARAIVLYEAAGLKPVRVKKEIAGFIFNRLQGAVLREAYCLVRDGVASVDDIDTVMRD
GLAPRWSVTGPFETVDLNTRGGIASHAQKMGPSYERLGAERGQSDPWTPELVAHVTAARRAALPLDQWDARVAWRDRRLM
QLARHRRLAAPDDD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=334, Percent_Identity=36.5269461077844, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI296179429, Length=279, Percent_Identity=30.4659498207885, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI296179427, Length=254, Percent_Identity=30.7086614173228, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1787661, Length=234, Percent_Identity=32.9059829059829, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533614, Length=203, Percent_Identity=38.9162561576355, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI193203623, Length=182, Percent_Identity=40.6593406593407, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=242, Percent_Identity=31.404958677686, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17549919, Length=247, Percent_Identity=30.3643724696356, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17563036, Length=259, Percent_Identity=26.2548262548263, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45549573, Length=303, Percent_Identity=36.3036303630363, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129993, Length=310, Percent_Identity=37.4193548387097, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36132; Mature: 36000

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVDRREAGSRHPRAGQPSAIGRAGIVGAGSIGVAFALVFARAGWRVRLFDPDPARRAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHC
APAEIAARLADLAHFALLDESADYIAARIELVESIEAAAADADLVQECAPERVELKRALF
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHH
AQLDRAAPAHAILASASSFLCASAFVDETVTGRARCLVAHPGNPPYLIPVIEIVPAPFTA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCCCCCC
EHTTARAIVLYEAAGLKPVRVKKEIAGFIFNRLQGAVLREAYCLVRDGVASVDDIDTVMR
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DGLAPRWSVTGPFETVDLNTRGGIASHAQKMGPSYERLGAERGQSDPWTPELVAHVTAAR
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
RAALPLDQWDARVAWRDRRLMQLARHRRLAAPDDD
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PPVDRREAGSRHPRAGQPSAIGRAGIVGAGSIGVAFALVFARAGWRVRLFDPDPARRAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHC
APAEIAARLADLAHFALLDESADYIAARIELVESIEAAAADADLVQECAPERVELKRALF
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHH
AQLDRAAPAHAILASASSFLCASAFVDETVTGRARCLVAHPGNPPYLIPVIEIVPAPFTA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCCCCCC
EHTTARAIVLYEAAGLKPVRVKKEIAGFIFNRLQGAVLREAYCLVRDGVASVDDIDTVMR
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DGLAPRWSVTGPFETVDLNTRGGIASHAQKMGPSYERLGAERGQSDPWTPELVAHVTAAR
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
RAALPLDQWDARVAWRDRRLMQLARHRRLAAPDDD
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]