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The map label for this gene is apbA [H]

Identifier: 189353493

GI number: 189353493

Start: 1711798

End: 1712736

Strand: Reverse

Name: apbA [H]

Synonym: BMULJ_04737

Alternate gene names: 189353493

Gene position: 1712736-1711798 (Counterclockwise)

Preceding gene: 189353495

Following gene: 189353492

Centisome position: 69.25

GC content: 71.14

Gene sequence:

>939_bases
ATGCGAATTCTGGTGGTAGGGGCCGGCGCGGTCGGCGGATATTTCGGCGGCCGGCTTGCGGCGGCGGGGCGCGACGTGAC
GTTTCTCGTGCGCGACGGCCGTGCGGCCGCACTCGCGCGCGACGGGCTCGTGATCCGCAGCCCGCGCGGCGACCTGACGC
TGCGCGACGTGCAGACCGTGCGCGCGGGCGACGGCGCCGCGCCGTTCGATCTGGTGCTGCTCAGCTGCAAGGCCTACAGC
CTCGACGATGCGATCGCGTCGTTCGCGCCGTTCGTCGGTCCGTCGACGCTGATCCTGCCGATGCTCAACGGGATGCGCCA
TCTCGACGTGCTGCGCGAGCGGTTCGGCGCGGCGCGCGTGCTCGGCGGGCTGTGCGTGATCGCGGCGACGCTCGACCGCG
AGCAGCACATCATGCATCTGAACGATACGCACGGGCTGTCGTTCGGCGAGCCGGGCGGCGGCGATTCGCCGCGCATGCAG
GCGCTGGCCGACGTGCTCGGCAACGCCGGCTTCGACGCGACGCTGAGCGACGACATCGTCGCGCGAATGTGGGACAAGTG
GGTGTTCCTCGCGACGCTGGCCGCGAGCACGTCGCTGTTCCGCGGCTCGGTCGGCGACATCCTGTCGGCGCCTGACGGCC
GCCGTCTGCTCGAAACGATGCTCGACGAATGCAGCGCGATCGCGGCGCACAACGGCTATCGGCCGGAGCCGCCCGCGATC
GCGCGGATGCAGCAGATGGTGCTGACGCCGTCGCCGCTCACCGCATCGATGCTGCGCGACATCGAGAACCGCGCGCGCGT
CGAGGCCGACCACGTGATCGGCGATCTGCTTGCGCGCCGCGATCCGGACGCGGGCGATGCGCTGTCGCTACTGCGGATCG
CATACAACCATCTGAAGACCTACGAGGCGCGCGTCGCGCGCGAGCGGGCCGCCGCGTAA

Upstream 100 bases:

>100_bases
TATACATAAGGTGCGTCGCTATACTGTCGGGCGGTGGCGTCGCGCGGGCGGCCCGGGCGGGCGGTGGCGCGGCGTCGAAC
GAAGCCGAAAGGAGGCAGCG

Downstream 100 bases:

>100_bases
CGGGCGTGCCGAGGCGGCGCGGGCGGGGCGGCGGTGCCCGCGCGCGCCGTTCCGCACTGCACAAATTTGCGCAACGACGC
CGTTTACGGTCCGAAAGCGC

Product: 2-dehydropantoate 2-reductase

Products: Nicotinamide adenine dinucleotide phosphate; (R)-Pantoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRILVVGAGAVGGYFGGRLAAAGRDVTFLVRDGRAAALARDGLVIRSPRGDLTLRDVQTVRAGDGAAPFDLVLLSCKAYS
LDDAIASFAPFVGPSTLILPMLNGMRHLDVLRERFGAARVLGGLCVIAATLDREQHIMHLNDTHGLSFGEPGGGDSPRMQ
ALADVLGNAGFDATLSDDIVARMWDKWVFLATLAASTSLFRGSVGDILSAPDGRRLLETMLDECSAIAAHNGYRPEPPAI
ARMQQMVLTPSPLTASMLRDIENRARVEADHVIGDLLARRDPDAGDALSLLRIAYNHLKTYEARVARERAAA

Sequences:

>Translated_312_residues
MRILVVGAGAVGGYFGGRLAAAGRDVTFLVRDGRAAALARDGLVIRSPRGDLTLRDVQTVRAGDGAAPFDLVLLSCKAYS
LDDAIASFAPFVGPSTLILPMLNGMRHLDVLRERFGAARVLGGLCVIAATLDREQHIMHLNDTHGLSFGEPGGGDSPRMQ
ALADVLGNAGFDATLSDDIVARMWDKWVFLATLAASTSLFRGSVGDILSAPDGRRLLETMLDECSAIAAHNGYRPEPPAI
ARMQQMVLTPSPLTASMLRDIENRARVEADHVIGDLLARRDPDAGDALSLLRIAYNHLKTYEARVARERAAA
>Mature_312_residues
MRILVVGAGAVGGYFGGRLAAAGRDVTFLVRDGRAAALARDGLVIRSPRGDLTLRDVQTVRAGDGAAPFDLVLLSCKAYS
LDDAIASFAPFVGPSTLILPMLNGMRHLDVLRERFGAARVLGGLCVIAATLDREQHIMHLNDTHGLSFGEPGGGDSPRMQ
ALADVLGNAGFDATLSDDIVARMWDKWVFLATLAASTSLFRGSVGDILSAPDGRRLLETMLDECSAIAAHNGYRPEPPAI
ARMQQMVLTPSPLTASMLRDIENRARVEADHVIGDLLARRDPDAGDALSLLRIAYNHLKTYEARVARERAAA

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169 [C]

Molecular weight: Translated: 33338; Mature: 33338

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGAVGGYFGGRLAAAGRDVTFLVRDGRAAALARDGLVIRSPRGDLTLRDVQTV
CEEEEEECCCHHHHCCCCCEECCCCEEEEEECCCEEEHHHCCEEEECCCCCEEHHHHHHH
RAGDGAAPFDLVLLSCKAYSLDDAIASFAPFVGPSTLILPMLNGMRHLDVLRERFGAARV
HCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGGLCVIAATLDREQHIMHLNDTHGLSFGEPGGGDSPRMQALADVLGNAGFDATLSDDIV
HHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
ARMWDKWVFLATLAASTSLFRGSVGDILSAPDGRRLLETMLDECSAIAAHNGYRPEPPAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ARMQQMVLTPSPLTASMLRDIENRARVEADHVIGDLLARRDPDAGDALSLLRIAYNHLKT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YEARVARERAAA
HHHHHHHHHCCC
>Mature Secondary Structure
MRILVVGAGAVGGYFGGRLAAAGRDVTFLVRDGRAAALARDGLVIRSPRGDLTLRDVQTV
CEEEEEECCCHHHHCCCCCEECCCCEEEEEECCCEEEHHHCCEEEECCCCCEEHHHHHHH
RAGDGAAPFDLVLLSCKAYSLDDAIASFAPFVGPSTLILPMLNGMRHLDVLRERFGAARV
HCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LGGLCVIAATLDREQHIMHLNDTHGLSFGEPGGGDSPRMQALADVLGNAGFDATLSDDIV
HHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
ARMWDKWVFLATLAASTSLFRGSVGDILSAPDGRRLLETMLDECSAIAAHNGYRPEPPAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ARMQQMVLTPSPLTASMLRDIENRARVEADHVIGDLLARRDPDAGDALSLLRIAYNHLKT
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YEARVARERAAA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: 2-Dehydropantoate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 2-Dehydropantoate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced --> Nicotinamide adenine dinucleotide phosphate + (R)-Pantoate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]