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The map label for this gene is iorA [H]

Identifier: 189353154

GI number: 189353154

Start: 1366221

End: 1366679

Strand: Direct

Name: iorA [H]

Synonym: BMULJ_04390

Alternate gene names: 189353154

Gene position: 1366221-1366679 (Clockwise)

Preceding gene: 189353152

Following gene: 189353155

Centisome position: 55.24

GC content: 69.5

Gene sequence:

>459_bases
ATGGTGACGTTGAACATCAATAACCGGCGGGCGGAAGTCGACGCCGATCCGTCGACGCCGGTGCTCTGGGTGCTGCGCGA
CAACCTCGGGCTGACGGGCACCAAGTTCGGCTGCGGGACCGGCGACTGCGGCGCATGCACCGTGCACGTCGACGGCCGGC
CGGTGCACAGCTGCACGCTGGCGCTCTCGTCAGTGGGCAGCGCGCGCATCACGACCTCCGAGCACCTGGCCGACGATGCG
GTCGGCAAGGCCGTCCTCGATGCGTGGCTCCGGCATGACGTCGCGCAATGCGGCTACTGCCAGAGCGGCCAGATGATGAG
TGCGGCCGGCCTGCTGCGGAGCAACAAGGCGCCGAGCGACGCCGACATCGACAGCGCGATGGCCGGCAATCTGTGCCGTT
GCGCCACCTACCAGCGCATCCGCGCCGCGATTCACGATGCGGCGCGGGCACTCGCCTGA

Upstream 100 bases:

>100_bases
GCTTTTTGGTTAATCTGCTTTAATCGATTTACATCACATCCGACGCATTACGATTTTCGTCTCGCGAACGATAACGACGT
GTCCAAGGGAGAATTTCACG

Downstream 100 bases:

>100_bases
GCCTGCCGGGAGATAGCGATCATGCGTATTGGCACTGCCGGGCGTCCGGCGCGTAGCGACGTCGTCGACGCCGAGGCTTC
TCCTGCAACCGGCGCCGCGG

Product: isoquinoline 1-oxidoreductase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTLALSSVGSARITTSEHLADDA
VGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSDADIDSAMAGNLCRCATYQRIRAAIHDAARALA

Sequences:

>Translated_152_residues
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTLALSSVGSARITTSEHLADDA
VGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSDADIDSAMAGNLCRCATYQRIRAAIHDAARALA
>Mature_152_residues
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTLALSSVGSARITTSEHLADDA
VGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSDADIDSAMAGNLCRCATYQRIRAAIHDAARALA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=156, Percent_Identity=36.5384615384615, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=41.1042944785276, Blast_Score=109, Evalue=8e-26,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=34, Blast_Score=86, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=154, Percent_Identity=35.7142857142857, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=32.9032258064516, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=32.258064516129, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737937, Length=147, Percent_Identity=36.734693877551, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647197, Length=162, Percent_Identity=32.7160493827161, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24647195, Length=162, Percent_Identity=32.7160493827161, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647193, Length=160, Percent_Identity=32.5, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647199, Length=130, Percent_Identity=33.8461538461538, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647201, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15928; Mature: 15928

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
CEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
ALSSVGSARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSD
HHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
ADIDSAMAGNLCRCATYQRIRAAIHDAARALA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
CEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
ALSSVGSARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSD
HHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
ADIDSAMAGNLCRCATYQRIRAAIHDAARALA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]