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The map label for this gene is mdtD [H]

Identifier: 189353106

GI number: 189353106

Start: 1288403

End: 1289791

Strand: Direct

Name: mdtD [H]

Synonym: BMULJ_04342

Alternate gene names: 189353106

Gene position: 1288403-1289791 (Clockwise)

Preceding gene: 189353102

Following gene: 189353108

Centisome position: 52.1

GC content: 69.04

Gene sequence:

>1389_bases
ATGTCCCGGGACGCTTCTCACACCGCGCTGCTCTGGATCGTCGCCGCTGCCTTCTTCATGCAGTCGCTCGATACGACGAT
CGTCAATACCGCCTTGCCGTCGATTGCACAGGGCCTGCATGCCTCGCCGCTCGCGATGCAGCCGGTCGTGGTCGTCTATA
CGCTGACGATGGCGATGCTCACACCCGCGTCCGGCTGGCTCGCGGACCGCTTCGGCACGCGCCGCGTGTTTTCGCTCGCG
ATTCTCGTGTTCGTGCTCGCGTCGATCGGATGCGCGGCATCGCATACGCTCGGTCAGCTCGTCGCCGCGCGCGCATTGCA
GGGTGTCGGCGGCTCGATGCTGCTGCCGATCGGCCGGCTCGCGGTGCTGCGCCGCGTGCCGGGCGAACAATACGTGTCGG
CGCTCGCGTTCGTCTCGATCGCCGCGCAGCTCGGGCCGATCGTCGGACCGACGCTCGGCGGCTGGCTCACGCAGGCGATC
TCGTGGCACTGGGTATTCATCGTCAACGTGCCGGTCGGCGCGGTCGGACTCGTCGCCGTGCAGCGCTTTCTGCCGCACGA
CCAGGCGACGCAGCCGCCGCCGTTCGACTTCATCGGCTGTGCGCTGCTGTCCGTCGCGATGGTCGCGCTGTCGCTCGCGA
TCGATCCGCCGATGGCCACGCAACGCGGTGCGTGGGCGAGCGGGCTCGCCGTGGTCGGGCTCGCCAGCGCGCTCGCCTAT
CTGCCGCATGCGCGCCGGCGCGCGCAGCCGCTGTTCCGCCTCGGGCTGTTTCGCGAGCCGAATTTCGGTGCGGGGCTGCT
CGGCAATCTGCTGTGCCGGATCGGTACGAGCGCGCTGCCGTTCATGCTGCCGCTGCTGATGCAGGTGCAGCTCGGCTATA
CGCCGTTGCAATCGGGGATGATGATGCTGCCCGCCGCGATCGCCGGCGTCGTCGCGAAGCGCTGGATCGCGCCGCTCGTC
CGGCGTTTCGGCTACGCGGCGTTTCTCGTCGTGAATACGGGCATCGTCGGCAGCGCGATCGCCGGCTTTGCGCTGGTGTC
CGCGCGGCCCGCGCCCGCGCTCGAAATCGCGCTGCTCGTCGTGTTCGGCGCCGCCAATTCGATGCAGTTCGCGGCGATGA
ACAGCGTGACGCTCAAGGGGCTGTCGCACGCCGATGCGGCGAGCGGCAACAGCCTCTTCACGATGATGCAGATGCTCGCG
ATGGGTCTCGGCGTATCGATCGGCGGCGGACTGATCAATCTGTTCGCCGCGCGCCTCGGCTCGACCGCGAGCGGCTTCAT
GCTCGCGTTCGTCTGCATGGGCGCGGTCACGTTGCTGTCGTCGCTCGTATTCCGACGCATCGATACGCCGGCCGCGCCGC
GTCCCGCGACGTCGCGGCCGGCCGCGTGA

Upstream 100 bases:

>100_bases
GCTCTGCACCTTCCCGACCGCCTCCGGAATCGGTACCATCGACCGCTTGAAAAACCGGTCGCACGCCGGACGGGCTGTGC
GCCGCACGCCGAACTTCGCC

Downstream 100 bases:

>100_bases
CACGTGCGGCGCGCCCGGCCGGCGGTCTTTAGTTCACGGGCCGTCGCTCGATGACGCGCTTGAGCACCCAGCGGATCGAC
GAGCGGTCTGCCGGCGGCTG

Product: permease of the major facilitator superfamily

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSRDASHTALLWIVAAAFFMQSLDTTIVNTALPSIAQGLHASPLAMQPVVVVYTLTMAMLTPASGWLADRFGTRRVFSLA
ILVFVLASIGCAASHTLGQLVAARALQGVGGSMLLPIGRLAVLRRVPGEQYVSALAFVSIAAQLGPIVGPTLGGWLTQAI
SWHWVFIVNVPVGAVGLVAVQRFLPHDQATQPPPFDFIGCALLSVAMVALSLAIDPPMATQRGAWASGLAVVGLASALAY
LPHARRRAQPLFRLGLFREPNFGAGLLGNLLCRIGTSALPFMLPLLMQVQLGYTPLQSGMMMLPAAIAGVVAKRWIAPLV
RRFGYAAFLVVNTGIVGSAIAGFALVSARPAPALEIALLVVFGAANSMQFAAMNSVTLKGLSHADAASGNSLFTMMQMLA
MGLGVSIGGGLINLFAARLGSTASGFMLAFVCMGAVTLLSSLVFRRIDTPAAPRPATSRPAA

Sequences:

>Translated_462_residues
MSRDASHTALLWIVAAAFFMQSLDTTIVNTALPSIAQGLHASPLAMQPVVVVYTLTMAMLTPASGWLADRFGTRRVFSLA
ILVFVLASIGCAASHTLGQLVAARALQGVGGSMLLPIGRLAVLRRVPGEQYVSALAFVSIAAQLGPIVGPTLGGWLTQAI
SWHWVFIVNVPVGAVGLVAVQRFLPHDQATQPPPFDFIGCALLSVAMVALSLAIDPPMATQRGAWASGLAVVGLASALAY
LPHARRRAQPLFRLGLFREPNFGAGLLGNLLCRIGTSALPFMLPLLMQVQLGYTPLQSGMMMLPAAIAGVVAKRWIAPLV
RRFGYAAFLVVNTGIVGSAIAGFALVSARPAPALEIALLVVFGAANSMQFAAMNSVTLKGLSHADAASGNSLFTMMQMLA
MGLGVSIGGGLINLFAARLGSTASGFMLAFVCMGAVTLLSSLVFRRIDTPAAPRPATSRPAA
>Mature_461_residues
SRDASHTALLWIVAAAFFMQSLDTTIVNTALPSIAQGLHASPLAMQPVVVVYTLTMAMLTPASGWLADRFGTRRVFSLAI
LVFVLASIGCAASHTLGQLVAARALQGVGGSMLLPIGRLAVLRRVPGEQYVSALAFVSIAAQLGPIVGPTLGGWLTQAIS
WHWVFIVNVPVGAVGLVAVQRFLPHDQATQPPPFDFIGCALLSVAMVALSLAIDPPMATQRGAWASGLAVVGLASALAYL
PHARRRAQPLFRLGLFREPNFGAGLLGNLLCRIGTSALPFMLPLLMQVQLGYTPLQSGMMMLPAAIAGVVAKRWIAPLVR
RFGYAAFLVVNTGIVGSAIAGFALVSARPAPALEIALLVVFGAANSMQFAAMNSVTLKGLSHADAASGNSLFTMMQMLAM
GLGVSIGGGLINLFAARLGSTASGFMLAFVCMGAVTLLSSLVFRRIDTPAAPRPATSRPAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=465, Percent_Identity=41.0752688172043, Blast_Score=348, Evalue=5e-97,
Organism=Escherichia coli, GI1788392, Length=464, Percent_Identity=42.4568965517241, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1789042, Length=412, Percent_Identity=29.126213592233, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788710, Length=412, Percent_Identity=27.9126213592233, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081983, Length=416, Percent_Identity=27.4038461538462, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325455, Length=158, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=160, Percent_Identity=28.75, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48107; Mature: 47976

Theoretical pI: Translated: 11.81; Mature: 11.81

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDASHTALLWIVAAAFFMQSLDTTIVNTALPSIAQGLHASPLAMQPVVVVYTLTMAML
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
TPASGWLADRFGTRRVFSLAILVFVLASIGCAASHTLGQLVAARALQGVGGSMLLPIGRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AVLRRVPGEQYVSALAFVSIAAQLGPIVGPTLGGWLTQAISWHWVFIVNVPVGAVGLVAV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEECCCHHHHHHHH
QRFLPHDQATQPPPFDFIGCALLSVAMVALSLAIDPPMATQRGAWASGLAVVGLASALAY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
LPHARRRAQPLFRLGLFREPNFGAGLLGNLLCRIGTSALPFMLPLLMQVQLGYTPLQSGM
HHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH
MMLPAAIAGVVAKRWIAPLVRRFGYAAFLVVNTGIVGSAIAGFALVSARPAPALEIALLV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHH
VFGAANSMQFAAMNSVTLKGLSHADAASGNSLFTMMQMLAMGLGVSIGGGLINLFAARLG
HHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
STASGFMLAFVCMGAVTLLSSLVFRRIDTPAAPRPATSRPAA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRDASHTALLWIVAAAFFMQSLDTTIVNTALPSIAQGLHASPLAMQPVVVVYTLTMAML
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
TPASGWLADRFGTRRVFSLAILVFVLASIGCAASHTLGQLVAARALQGVGGSMLLPIGRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AVLRRVPGEQYVSALAFVSIAAQLGPIVGPTLGGWLTQAISWHWVFIVNVPVGAVGLVAV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEECCCHHHHHHHH
QRFLPHDQATQPPPFDFIGCALLSVAMVALSLAIDPPMATQRGAWASGLAVVGLASALAY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
LPHARRRAQPLFRLGLFREPNFGAGLLGNLLCRIGTSALPFMLPLLMQVQLGYTPLQSGM
HHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH
MMLPAAIAGVVAKRWIAPLVRRFGYAAFLVVNTGIVGSAIAGFALVSARPAPALEIALLV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHH
VFGAANSMQFAAMNSVTLKGLSHADAASGNSLFTMMQMLAMGLGVSIGGGLINLFAARLG
HHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
STASGFMLAFVCMGAVTLLSSLVFRRIDTPAAPRPATSRPAA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA