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The map label for this gene is ggt [H]

Identifier: 189352860

GI number: 189352860

Start: 990471

End: 992192

Strand: Direct

Name: ggt [H]

Synonym: BMULJ_04094

Alternate gene names: 189352860

Gene position: 990471-992192 (Clockwise)

Preceding gene: 189352856

Following gene: 189352861

Centisome position: 40.05

GC content: 64.29

Gene sequence:

>1722_bases
ATGACTACGCTGAATCGCTTCAAATCATCCGCCGTCGTGTTCGCGACGGTGGCCGGCATCGGTTTCCTGCCGAACGCACC
CGTTTATGCGAAGGGCCCGCAACCCGCGGTGCTGACGAGTTCGGCCGTCGCGGTCGCCGACAAGTACAGCGCGGATGCCG
CCGAGCAGATCTTCAAGGAAGGCGGCAACGCGATCGACGCGGCCGTCGCCATCGCATTCACGCTCGCCGTCACGTATCCG
GAAGCCGGCAACATCGGCGGCGGCGGCTTCATGACGATCTACAAGGACGGCAAGCCGTACTTCATCGACTACCGCGAACG
CGCGCCGCTCGCGGCGACGAAGGACATGTACCTCGACAAGGACGGCAACGTCATCAAGGGGATGAGCCTCTACGGTCCGC
GCGCGGTCGGCGTGCCGGGCACGGTCGCCGGCATGTGGGAGGTGCAGAAGCGCTTCGGCAAGCTGAAGTGGAAGCAGGTG
CTCGCGCCGGCGATCCACTACGCGCGCGACGGCTTCATCGTCGACGAGCAGCTCGCGCAGCGCGGCGTCGATGCATCGAA
GGAGTTCGGCGGCAAGACGAACTTCGACAAGTACTTCTCGGGGCTGAAGGCCGGTGCGAACTTCAAGCAGCCCGATCTCG
CCGCCGTGCTGACGCGCATCGCGAACCAGGGTGCGGAAGGCTTTTACAAGGGCAAGACGGCCGAGCTGATTGCCGCGTCG
ATGAAGAGCGGCGACGGCAACGGCCTGATCACGACCGAGGATCTCGCGCAATATCGCGCGGTGTGGCGCGAGCCCGTGCA
GGCCAAGTGGAACGGCTACGACGTGATCACCGCGCCGCCGCCGAGCTCGGGCGGGATCGGCCTCGTGCAGCTGCTGAAGA
TGAAGGCCGATCTGAAGCAGGATTTCGAGGGCGTGACGCTGAACTCGCCGCAATACATCCATCTCGTCGCCGAAATCGAG
AAGCGTGTGTTCGCCGATCGTGCGCAGTATCTCGGCGATCCGGATTTCTACAAGGTGCCGGTCGCGCAGCTGACCGACGA
CGCCTATATCGCGAAGCGCGCAGCCGAAGTCAACCCGAAGGAGCCGTCCGATACGAAGAGCGTGCAGCCTGGCCTCGGCA
CGACGATGCCGGAGAAGGCCGAGACGACGCATTTCTCCGTCGTCGACAAGTGGGGCAACGCGGTCTCGAACACGTACACG
ATCAACGGCTATTTCGGGTCGGGCGTGATTGCCGACGGCACGGGCATCGTGCTGAACGACGAGATGGACGACTTCTCCGC
GAAGCCGGGCGTCGCGAACATGTTCGGCGTGGTCGGCAGCGACGCGAACGCGATCGAGCCGAAGAAGCGTCCGCTGTCGT
CGATGTCGCCGACGATCCTGACGAAGGACGGCAAGGTGTCGCTCGTGATCGGCACGCCGGGCGGCTCGCGGATCTTCACG
TCGATCTTCCAGGTGATCAACAACATCTACGACTTCAAGATGCCGTTGAAGGAGGCCGTCGGCGCGATGCGCTTCCATCA
CCAGCTGCTGCCGCCGAACACGATCTTCTGGGAGCCGTACCACCCGATCGAGGGTGAGCTCGCGAAGCAGCTCGAGGCGC
GCGGCTATACGCTGAAGGGACAGGACTTCAGCGGCGACATCCAGGTGATCAAGGTCGACGGAAAGACGCCGGAAGCGGTG
GCCGATCCGCGCGGACGCGGCGTGACGCGCATCATCCGGTAA

Upstream 100 bases:

>100_bases
CCTATACTACGAAACCGGCCTATGGTCGCCGGCGCGCCAGCGGCTATAAACGGATCGGGTGCTTTTCCAGCCTGAAGGAG
ATCCATATGGGGGACATGCA

Downstream 100 bases:

>100_bases
CGCGCGTCATTCGCGCGGTCGCGCCGTCCGGCGGCCGCGCTGGCAATCGAGACGCCGGGTTCGCGCCCGGCGTTTTCCGT
TGTGGACCGGCGCATGCGGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTTLNRFKSSAVVFATVAGIGFLPNAPVYAKGPQPAVLTSSAVAVADKYSADAAEQIFKEGGNAIDAAVAIAFTLAVTYP
EAGNIGGGGFMTIYKDGKPYFIDYRERAPLAATKDMYLDKDGNVIKGMSLYGPRAVGVPGTVAGMWEVQKRFGKLKWKQV
LAPAIHYARDGFIVDEQLAQRGVDASKEFGGKTNFDKYFSGLKAGANFKQPDLAAVLTRIANQGAEGFYKGKTAELIAAS
MKSGDGNGLITTEDLAQYRAVWREPVQAKWNGYDVITAPPPSSGGIGLVQLLKMKADLKQDFEGVTLNSPQYIHLVAEIE
KRVFADRAQYLGDPDFYKVPVAQLTDDAYIAKRAAEVNPKEPSDTKSVQPGLGTTMPEKAETTHFSVVDKWGNAVSNTYT
INGYFGSGVIADGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTILTKDGKVSLVIGTPGGSRIFT
SIFQVINNIYDFKMPLKEAVGAMRFHHQLLPPNTIFWEPYHPIEGELAKQLEARGYTLKGQDFSGDIQVIKVDGKTPEAV
ADPRGRGVTRIIR

Sequences:

>Translated_573_residues
MTTLNRFKSSAVVFATVAGIGFLPNAPVYAKGPQPAVLTSSAVAVADKYSADAAEQIFKEGGNAIDAAVAIAFTLAVTYP
EAGNIGGGGFMTIYKDGKPYFIDYRERAPLAATKDMYLDKDGNVIKGMSLYGPRAVGVPGTVAGMWEVQKRFGKLKWKQV
LAPAIHYARDGFIVDEQLAQRGVDASKEFGGKTNFDKYFSGLKAGANFKQPDLAAVLTRIANQGAEGFYKGKTAELIAAS
MKSGDGNGLITTEDLAQYRAVWREPVQAKWNGYDVITAPPPSSGGIGLVQLLKMKADLKQDFEGVTLNSPQYIHLVAEIE
KRVFADRAQYLGDPDFYKVPVAQLTDDAYIAKRAAEVNPKEPSDTKSVQPGLGTTMPEKAETTHFSVVDKWGNAVSNTYT
INGYFGSGVIADGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTILTKDGKVSLVIGTPGGSRIFT
SIFQVINNIYDFKMPLKEAVGAMRFHHQLLPPNTIFWEPYHPIEGELAKQLEARGYTLKGQDFSGDIQVIKVDGKTPEAV
ADPRGRGVTRIIR
>Mature_572_residues
TTLNRFKSSAVVFATVAGIGFLPNAPVYAKGPQPAVLTSSAVAVADKYSADAAEQIFKEGGNAIDAAVAIAFTLAVTYPE
AGNIGGGGFMTIYKDGKPYFIDYRERAPLAATKDMYLDKDGNVIKGMSLYGPRAVGVPGTVAGMWEVQKRFGKLKWKQVL
APAIHYARDGFIVDEQLAQRGVDASKEFGGKTNFDKYFSGLKAGANFKQPDLAAVLTRIANQGAEGFYKGKTAELIAASM
KSGDGNGLITTEDLAQYRAVWREPVQAKWNGYDVITAPPPSSGGIGLVQLLKMKADLKQDFEGVTLNSPQYIHLVAEIEK
RVFADRAQYLGDPDFYKVPVAQLTDDAYIAKRAAEVNPKEPSDTKSVQPGLGTTMPEKAETTHFSVVDKWGNAVSNTYTI
NGYFGSGVIADGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTILTKDGKVSLVIGTPGGSRIFTS
IFQVINNIYDFKMPLKEAVGAMRFHHQLLPPNTIFWEPYHPIEGELAKQLEARGYTLKGQDFSGDIQVIKVDGKTPEAVA
DPRGRGVTRIIR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=507, Percent_Identity=33.9250493096647, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI73915090, Length=507, Percent_Identity=33.9250493096647, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI73915096, Length=507, Percent_Identity=33.9250493096647, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI73915094, Length=507, Percent_Identity=33.9250493096647, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI113429324, Length=566, Percent_Identity=31.2720848056537, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI113429326, Length=513, Percent_Identity=31.5789473684211, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI109148539, Length=581, Percent_Identity=29.2598967297762, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI153266885, Length=549, Percent_Identity=26.5938069216758, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=26.7272727272727, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI153266907, Length=547, Percent_Identity=25.4113345521024, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI30581157, Length=163, Percent_Identity=45.398773006135, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI30581155, Length=163, Percent_Identity=45.398773006135, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI218505805, Length=170, Percent_Identity=40.5882352941176, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310124095, Length=137, Percent_Identity=41.6058394160584, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789856, Length=544, Percent_Identity=45.4044117647059, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212646519, Length=504, Percent_Identity=35.7142857142857, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=504, Percent_Identity=35.7142857142857, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193208245, Length=495, Percent_Identity=32.9292929292929, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193208247, Length=495, Percent_Identity=32.9292929292929, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17506189, Length=561, Percent_Identity=32.4420677361854, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17542894, Length=548, Percent_Identity=32.4817518248175, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17564448, Length=441, Percent_Identity=25.3968253968254, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72001495, Length=228, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=544, Percent_Identity=31.4338235294118, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI18859893, Length=477, Percent_Identity=37.7358490566038, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161077496, Length=554, Percent_Identity=31.4079422382672, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI45551474, Length=527, Percent_Identity=30.9297912713473, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642670, Length=527, Percent_Identity=30.9297912713473, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642666, Length=527, Percent_Identity=30.9297912713473, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161077880, Length=527, Percent_Identity=30.9297912713473, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161077878, Length=527, Percent_Identity=30.9297912713473, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI18859741, Length=548, Percent_Identity=27.7372262773723, Blast_Score=186, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61780; Mature: 61649

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLNRFKSSAVVFATVAGIGFLPNAPVYAKGPQPAVLTSSAVAVADKYSADAAEQIFKE
CCCHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCEEECCHHHHHHHCCHHHHHHHHHC
GGNAIDAAVAIAFTLAVTYPEAGNIGGGGFMTIYKDGKPYFIDYRERAPLAATKDMYLDK
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCEEECC
DGNVIKGMSLYGPRAVGVPGTVAGMWEVQKRFGKLKWKQVLAPAIHYARDGFIVDEQLAQ
CCCEEECEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECHHHHH
RGVDASKEFGGKTNFDKYFSGLKAGANFKQPDLAAVLTRIANQGAEGFYKGKTAELIAAS
CCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MKSGDGNGLITTEDLAQYRAVWREPVQAKWNGYDVITAPPPSSGGIGLVQLLKMKADLKQ
HCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
DFEGVTLNSPQYIHLVAEIEKRVFADRAQYLGDPDFYKVPVAQLTDDAYIAKRAAEVNPK
CCCCEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCEECCHHHHCCHHHHHHHHHCCCCC
EPSDTKSVQPGLGTTMPEKAETTHFSVVDKWGNAVSNTYTINGYFGSGVIADGTGIVLND
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCEEECCCEEEECC
EMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTILTKDGKVSLVIGTPGGSRIFT
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHH
SIFQVINNIYDFKMPLKEAVGAMRFHHQLLPPNTIFWEPYHPIEGELAKQLEARGYTLKG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCEECC
QDFSGDIQVIKVDGKTPEAVADPRGRGVTRIIR
CCCCCCEEEEEECCCCCHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
TTLNRFKSSAVVFATVAGIGFLPNAPVYAKGPQPAVLTSSAVAVADKYSADAAEQIFKE
CCHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCEEECCHHHHHHHCCHHHHHHHHHC
GGNAIDAAVAIAFTLAVTYPEAGNIGGGGFMTIYKDGKPYFIDYRERAPLAATKDMYLDK
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCEEECC
DGNVIKGMSLYGPRAVGVPGTVAGMWEVQKRFGKLKWKQVLAPAIHYARDGFIVDEQLAQ
CCCEEECEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECHHHHH
RGVDASKEFGGKTNFDKYFSGLKAGANFKQPDLAAVLTRIANQGAEGFYKGKTAELIAAS
CCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MKSGDGNGLITTEDLAQYRAVWREPVQAKWNGYDVITAPPPSSGGIGLVQLLKMKADLKQ
HCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
DFEGVTLNSPQYIHLVAEIEKRVFADRAQYLGDPDFYKVPVAQLTDDAYIAKRAAEVNPK
CCCCEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCEECCHHHHCCHHHHHHHHHCCCCC
EPSDTKSVQPGLGTTMPEKAETTHFSVVDKWGNAVSNTYTINGYFGSGVIADGTGIVLND
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCEEECCCEEEECC
EMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTILTKDGKVSLVIGTPGGSRIFT
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHH
SIFQVINNIYDFKMPLKEAVGAMRFHHQLLPPNTIFWEPYHPIEGELAKQLEARGYTLKG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHCCCEECC
QDFSGDIQVIKVDGKTPEAVADPRGRGVTRIIR
CCCCCCEEEEEECCCCCHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]