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The map label for this gene is prdF

Identifier: 189352828

GI number: 189352828

Start: 951490

End: 952425

Strand: Direct

Name: prdF

Synonym: BMULJ_04062

Alternate gene names: NA

Gene position: 951490-952425 (Clockwise)

Preceding gene: 189352822

Following gene: 189352829

Centisome position: 38.47

GC content: 69.98

Gene sequence:

>936_bases
ATGATGAAGCGCATCCAGATCATCGATTCGCACACGGGCGGCGAACCCACGCGGCTCGTCGTGTCCGGCTTTCCGTCGCT
CGGCAGCGGCACGATGGCCGAGCGGCGCGACGTGCTCGCGCGCGAGTACGACCGCTATCGCACCGCGTGCATTCTCGAAC
CGCGCGGCAGCGACGTGCTCGTCGGCGCGCTGCTGTGCGAGCCCGTGTCGCCCGACGCCGCGGCCGGCGTGATCTTCTTC
AACAACAGCGGTTATCTCGGCATGTGCGGGCACGGCACGATCGGCGTCGTGCGCACGCTGCATCACATGGGCCGCATCGG
GCCCGGCGTGCACCGGATCGAAACGCCGGTCGGCACCGTCGAGGCGACGCTGCACGACGATCTGTCGGTCAGCGTGCGCA
ACGTGCTCGCGTATCGCCACGCGAAGGACGTCGCGCTCGACGTGCCGGGCTACGGTCCGGTGCGCGGCGACATCGCGTGG
GGCGGCAACTGGTTCTTCCTGATCAGCGATCACGGGCAGCGCGTCGCCGGCGACAACGTCGCGGCGCTGACGGCGTACGC
GAGCGCGGTGCGCGAAGGGCTCGAACGCGCGGGCATCACGGGCGCGAACGGCGGCGAGATCGATCACATCGAACTGTTCG
CGGACGATCCCGAACACGACAGCCGCAGCTTCGTGCTGTGCCCCGGTCTCGCCTACGATCGCTCGCCGTGCGGCACCGGC
ACCAGCGCGAAGCTCGCGTGCCTCGCGGCCGACGGCAAGCTCGCGCCGGGCGCGGTGTGGCGCCAGGCGAGCGTGATCGG
CAGCGTGTTCCACGCGAGCTATGTGCAGGCCGAAGGCGGCATCGTGCCGACGATTCGCGGCAGCGCGCATCTGAGCGCCG
AAGCGACGCTGCTGATCGAGGACGACGATCCGTTCCGCTGGGGCATCGTGTCGTGA

Upstream 100 bases:

>100_bases
CGCGCTATGCCGATTTCGTCGCCGCCCTCATTGAAAACCCACAAGCGGCCGGACGCGCGACGGAGGAAGCTATGCCCCTT
TCCCCACTTTCGGACGACGC

Downstream 100 bases:

>100_bases
GCGAATCGGCAACCGACGTCGTCGTGATCGGCGCGGGCATCGTCGGCGCCGCGTGCGCGCACGAGCTCGCGCAGCGCGGG
CTGCGCGTGATCGTCGTCGA

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MMKRIQIIDSHTGGEPTRLVVSGFPSLGSGTMAERRDVLAREYDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFF
NNSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVALDVPGYGPVRGDIAW
GGNWFFLISDHGQRVAGDNVAALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTG
TSAKLACLAADGKLAPGAVWRQASVIGSVFHASYVQAEGGIVPTIRGSAHLSAEATLLIEDDDPFRWGIVS

Sequences:

>Translated_311_residues
MMKRIQIIDSHTGGEPTRLVVSGFPSLGSGTMAERRDVLAREYDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFF
NNSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVALDVPGYGPVRGDIAW
GGNWFFLISDHGQRVAGDNVAALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTG
TSAKLACLAADGKLAPGAVWRQASVIGSVFHASYVQAEGGIVPTIRGSAHLSAEATLLIEDDDPFRWGIVS
>Mature_311_residues
MMKRIQIIDSHTGGEPTRLVVSGFPSLGSGTMAERRDVLAREYDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFF
NNSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVALDVPGYGPVRGDIAW
GGNWFFLISDHGQRVAGDNVAALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTG
TSAKLACLAADGKLAPGAVWRQASVIGSVFHASYVQAEGGIVPTIRGSAHLSAEATLLIEDDDPFRWGIVS

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases [H]

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=336, Percent_Identity=30.6547619047619, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 32899; Mature: 32899

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRIQIIDSHTGGEPTRLVVSGFPSLGSGTMAERRDVLAREYDRYRTACILEPRGSDVL
CCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEE
VGALLCEPVSPDAAAGVIFFNNSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTV
EEEEEECCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCEE
EATLHDDLSVSVRNVLAYRHAKDVALDVPGYGPVRGDIAWGGNWFFLISDHGQRVAGDNV
EEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCEEEEEECCCCCEECCCCH
AALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCC
TSAKLACLAADGKLAPGAVWRQASVIGSVFHASYVQAEGGIVPTIRGSAHLSAEATLLIE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCEEECCEEEEEEE
DDDPFRWGIVS
CCCCCEEECCC
>Mature Secondary Structure
MMKRIQIIDSHTGGEPTRLVVSGFPSLGSGTMAERRDVLAREYDRYRTACILEPRGSDVL
CCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEE
VGALLCEPVSPDAAAGVIFFNNSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTV
EEEEEECCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCEE
EATLHDDLSVSVRNVLAYRHAKDVALDVPGYGPVRGDIAWGGNWFFLISDHGQRVAGDNV
EEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCEEEEEECCCCCEECCCCH
AALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCC
TSAKLACLAADGKLAPGAVWRQASVIGSVFHASYVQAEGGIVPTIRGSAHLSAEATLLIE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCEEECCEEEEEEE
DDDPFRWGIVS
CCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA