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The map label for this gene is ilvD [H]

Identifier: 189352824

GI number: 189352824

Start: 944715

End: 946574

Strand: Reverse

Name: ilvD [H]

Synonym: BMULJ_04058

Alternate gene names: 189352824

Gene position: 946574-944715 (Counterclockwise)

Preceding gene: 189352825

Following gene: 189352823

Centisome position: 38.27

GC content: 66.56

Gene sequence:

>1860_bases
ATGCCCACATACCGTTCCAAAACCTCCACCGCCGGCCGCAACATGGCGGGCGCGCGCTCGCTGTGGCGCGCCACCGGCAT
GAAAGACGACGATTTCCAGAAACCGATCATCGCCGTCGTCAACTCGTTCACGCAGTTCGTGCCCGGGCACGTGCACCTGA
AGGATCTCGGCCAGCTCGTCGCGCGCGAGATCGAAGCCGCCGGCGGCGTCGCGAAGGAATTCAACACGATCGCCGTCGAC
GACGGCATCGCGATGGGCCACGACGGGATGCTCTATTCGCTGCCGAGCCGCGACATCATCGCCGACTCGGTCGAATACAT
GGTCAACGCGCACTGCGCGGACGCGATGGTCTGCATCTCGAACTGCGACAAGATCACGCCGGGCATGCTGATGGCCGCGA
TGCGCCTGAACATTCCGGTGATCTTCGTGTCGGGCGGCCCGATGGAAGCCGGCAAGACGCGCCTCGCGAACCCCGTCACG
AAGACCGTCGAACTGAAAAAGCTCGACCTCGTCGACGCGATGGTGATCGCAGCCGACCAGTCCTACTCCGATGCCGACGT
CGCCGAAGTCGAACGCTCCGCCTGCCCGACCTGCGGGTCGTGCTCGGGGATGTTCACCGCGAACTCGATGAACTGCCTGA
CCGAAGCGCTCGGCCTCTCGCTGCCGGGCAACGGCACGGTCGTCGCGACGCACGCCGATCGCGAACAGCTGTTCAAGCGC
GCCGGCCGCCGCATCGTCGAACTGACGCGCCAGTACTACGAGCAGGACGACGAACGCGTGCTGCCGCGCTCGGTCGGCTT
CAAGGCGTTCGAGAACGCGATGACGCTCGACATCGCGATGGGCGGCTCGACGAACACGATCCTGCACCTGCTCGCGGTCG
CGCAGGAAGCCGGGATCGCGTTCACGATGAAGGACATCGATCGCCTGTCGCGCGTCGTTCCGCAGCTCTGCAAGGTTGCG
CCGAACACGAACAAGTACCACATCGAAGACGTGCATCGCGCCGGCGGGATCATGGCGATCCTCGGCGAACTCGATCGCGC
CGGCAAGCTGCACACCGACGTGCCGACCGTGCACGCACCGACGCTGAAGGACGCGCTCGATCAGTGGGACATCGTCCGTA
CGCAGGACGAAGCGGTCCGCAAGTTCTATCTGGCCGGCCCGGCCGGGATTCCGACGCAGGTCGCGTTCAGCCAGGACACG
CGCTGGCCGAGCCTCGACCTCGATCGCGCCGAAGGCTGCATCCGCTCGTACGAGCACGCGTTCTCGAAGGAAGGCGGGCT
CGCGGTGCTGACCGGCAACATCGCGCTCGACGGCTGCGTGGTGAAGACGGCCGGCGTCGACGAGAGCATCCTCGTCTTCG
AAGGCACCGCGCATGTGACCGAATCGCAGGATGAGGCGGTCGAGCACATCCTGAACGACCAGGTGAAGGCCGGCGACGTC
GTGATCGTCCGCTACGAAGGCCCGAAGGGCGGCCCCGGGATGCAGGAAATGCTGTACCCGACGAGCTACATCAAGTCGAA
GGGCCTCGGCAAGGCGTGCGCGCTGCTGACAGACGGCCGCTTCTCGGGCGGCACGTCGGGTCTGTCGATCGGCCACTGCT
CGCCGGAAGCGGCGGCCGGCGGCGCGATCGGTCTCGTGCGCGACGGCGACAAGATCCGCATCGACATCCCGAACCGCACG
ATCGACGTGCTGGTGTCCGACGAGGAACTGGCGCGCCGTCGCGAGGAGCAGAACGCGAAGGGCTGGAAGCCGGCGAAGCC
GCGGCCGCGCAAGGTGTCCGCGGCGCTGAAGGCGTACGCGAAGCTTGTGATGTCGGCCGACAAGGGCGCCGTGCGCGACC
TGTCGCTGCTCGACGACTGA

Upstream 100 bases:

>100_bases
TTTGCCCAGGGCGCAGCTCAAGAGGTTGTTCGCACGGGCGCGCGAGGGGCCTCAATCCCGTGCCCCCACCCTTTTCCGCG
ATCTTTCTTCAGCAACCACA

Downstream 100 bases:

>100_bases
TGCCGGCGCGCGGGCGTCTGCCCGCGCGTCTGCGAAGCCGCTCCACGGAGCGGCTTTTTTTATGTCGTCGCCGATAGCCA
GGGAATGCCGTCGCAGCGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPTYRSKTSTAGRNMAGARSLWRATGMKDDDFQKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KTVELKKLDLVDAMVIAADQSYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELTRQYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAVAQEAGIAFTMKDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELDRAGKLHTDVPTVHAPTLKDALDQWDIVRTQDEAVRKFYLAGPAGIPTQVAFSQDT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVEHILNDQVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
IDVLVSDEELARRREEQNAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Sequences:

>Translated_619_residues
MPTYRSKTSTAGRNMAGARSLWRATGMKDDDFQKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KTVELKKLDLVDAMVIAADQSYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELTRQYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAVAQEAGIAFTMKDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELDRAGKLHTDVPTVHAPTLKDALDQWDIVRTQDEAVRKFYLAGPAGIPTQVAFSQDT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVEHILNDQVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
IDVLVSDEELARRREEQNAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
>Mature_618_residues
PTYRSKTSTAGRNMAGARSLWRATGMKDDDFQKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTK
TVELKKLDLVDAMVIAADQSYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRA
GRRIVELTRQYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAVAQEAGIAFTMKDIDRLSRVVPQLCKVAP
NTNKYHIEDVHRAGGIMAILGELDRAGKLHTDVPTVHAPTLKDALDQWDIVRTQDEAVRKFYLAGPAGIPTQVAFSQDTR
WPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVEHILNDQVKAGDVV
IVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRTI
DVLVSDEELARRREEQNAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=74.5571658615137, Blast_Score=940, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=545, Percent_Identity=30.6422018348624, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI2367371, Length=519, Percent_Identity=31.9845857418112, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786464, Length=558, Percent_Identity=31.1827956989247, Blast_Score=185, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=611, Percent_Identity=37.6432078559738, Blast_Score=355, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66560; Mature: 66429

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTYRSKTSTAGRNMAGARSLWRATGMKDDDFQKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKTVELKKLDLVDAMVIAADQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHEEHHHHHHHHEEEEEECC
SYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELTRQYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAVAQEAGIA
HHHHHHHHHHHHHCCCCCCCCCHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCE
FTMKDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELDRAGKLHTDVPTVHAP
EEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLKDALDQWDIVRTQDEAVRKFYLAGPAGIPTQVAFSQDTRWPSLDLDRAEGCIRSYEHA
HHHHHHHHHCEECCHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVEHILNDQVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTIDVLVSDEELARRREEQNAKGWKPAKPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PTYRSKTSTAGRNMAGARSLWRATGMKDDDFQKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKTVELKKLDLVDAMVIAADQ
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHEEHHHHHHHHEEEEEECC
SYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELTRQYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAVAQEAGIA
HHHHHHHHHHHHHCCCCCCCCCHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCE
FTMKDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELDRAGKLHTDVPTVHAP
EEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLKDALDQWDIVRTQDEAVRKFYLAGPAGIPTQVAFSQDTRWPSLDLDRAEGCIRSYEHA
HHHHHHHHHCEECCHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVEHILNDQVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTIDVLVSDEELARRREEQNAKGWKPAKPRPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA