Click here to switch to the map view.

The map label for this gene is iclR [H]

Identifier: 189352757

GI number: 189352757

Start: 868971

End: 869723

Strand: Reverse

Name: iclR [H]

Synonym: BMULJ_03989

Alternate gene names: 189352757

Gene position: 869723-868971 (Counterclockwise)

Preceding gene: 189352760

Following gene: 189352749

Centisome position: 35.17

GC content: 73.31

Gene sequence:

>753_bases
ATGCTTCCCGCCGATACGCCCACGCTGCGCGCGTTCGCGCTGCTCGAACATCTGGTCCAGGCGGGCGATGCCGTGTCGCT
CGCCGATCTCGCGCGCGAGGTCGACGTGCCGAAGGCGTCGCTGCACCGGATGCTCGCGTCGCTCGAAGCGGGCGGCCTCG
TGATCCGCGAGCCGGGCCGCAAGAACGCCTACGCGGTCGGCCCGCGGCTCGCGCGGCTCGGGGCGCGCGTGATGCTCAAT
GCCGGCGCGCGGCGGCTGCGCCATGCGATCCTCGCGCGGCTCGTCGCCGATCTCGGCGAAACCTGCAACCTGACGATGCT
GCACGATACCGACGTCGTCTATCTGGACCGCGTCGAGGCCGACTGGCCGCTGCGGCTCGACCTGAAGCCCGGCTCGCGCG
TGCCCGCGCACTGCAGCGCGAGCGGCAAGCTGCTGCTCGCGCTGCTGCCGCGCGACGAGCGCAACGCGCTGCTGCGCGCG
ATGCCGTTGCCGCGCCATACGCCCAACACGATCGCCGATCCGGCGCTGCTCGAGGCCGAGCTCGACCGCATCGCGCATCG
CGGGCTCGCGATCGACAACGAGGAGTTCGTCCCCGGCATCGTCTGCATCGCCGCGCCGATCGTCGATGCGCAAGGCGCGT
GCGTCGCCGCCGTCGCCGTGCATGCGCCCGTGTCGCGTGCGCCGCTGTCGCGGCTGCTCGACAGCGCGCCGCGCGTGCAG
GAGGCCGCGCGGGCGCTCGCCGAGACGTTCTAG

Upstream 100 bases:

>100_bases
GAAATGCGGGCCGCTTTGCGCGGCACGCCGGCCCGCGCGCCGCGTGTGCGGGGCCGTTCGGTACAATGGCCGCAGTCCAT
TTTCCGGAACGATGCTGCCG

Downstream 100 bases:

>100_bases
CACCGCGCCGCGCATCATGATGCGCGCTGGTAGTAGATGTTCTGCGGATGGCGCGCATCCGCGAAAAAGAACCAGCGCTC
CGCGACAAGTCCCGCATACT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MLPADTPTLRAFALLEHLVQAGDAVSLADLAREVDVPKASLHRMLASLEAGGLVIREPGRKNAYAVGPRLARLGARVMLN
AGARRLRHAILARLVADLGETCNLTMLHDTDVVYLDRVEADWPLRLDLKPGSRVPAHCSASGKLLLALLPRDERNALLRA
MPLPRHTPNTIADPALLEAELDRIAHRGLAIDNEEFVPGIVCIAAPIVDAQGACVAAVAVHAPVSRAPLSRLLDSAPRVQ
EAARALAETF

Sequences:

>Translated_250_residues
MLPADTPTLRAFALLEHLVQAGDAVSLADLAREVDVPKASLHRMLASLEAGGLVIREPGRKNAYAVGPRLARLGARVMLN
AGARRLRHAILARLVADLGETCNLTMLHDTDVVYLDRVEADWPLRLDLKPGSRVPAHCSASGKLLLALLPRDERNALLRA
MPLPRHTPNTIADPALLEAELDRIAHRGLAIDNEEFVPGIVCIAAPIVDAQGACVAAVAVHAPVSRAPLSRLLDSAPRVQ
EAARALAETF
>Mature_250_residues
MLPADTPTLRAFALLEHLVQAGDAVSLADLAREVDVPKASLHRMLASLEAGGLVIREPGRKNAYAVGPRLARLGARVMLN
AGARRLRHAILARLVADLGETCNLTMLHDTDVVYLDRVEADWPLRLDLKPGSRVPAHCSASGKLLLALLPRDERNALLRA
MPLPRHTPNTIADPALLEAELDRIAHRGLAIDNEEFVPGIVCIAAPIVDAQGACVAAVAVHAPVSRAPLSRLLDSAPRVQ
EAARALAETF

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=237, Percent_Identity=29.1139240506329, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788131, Length=245, Percent_Identity=29.3877551020408, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786715, Length=238, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=26.8292682926829, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790752, Length=220, Percent_Identity=28.1818181818182, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1789999, Length=232, Percent_Identity=28.448275862069, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788581, Length=211, Percent_Identity=25.1184834123223, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 26769; Mature: 26769

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED ; PS00356 HTH_LACI_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPADTPTLRAFALLEHLVQAGDAVSLADLAREVDVPKASLHRMLASLEAGGLVIREPGR
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCC
KNAYAVGPRLARLGARVMLNAGARRLRHAILARLVADLGETCNLTMLHDTDVVYLDRVEA
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECC
DWPLRLDLKPGSRVPAHCSASGKLLLALLPRDERNALLRAMPLPRHTPNTIADPALLEAE
CCCEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LDRIAHRGLAIDNEEFVPGIVCIAAPIVDAQGACVAAVAVHAPVSRAPLSRLLDSAPRVQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHH
EAARALAETF
HHHHHHHHCC
>Mature Secondary Structure
MLPADTPTLRAFALLEHLVQAGDAVSLADLAREVDVPKASLHRMLASLEAGGLVIREPGR
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCC
KNAYAVGPRLARLGARVMLNAGARRLRHAILARLVADLGETCNLTMLHDTDVVYLDRVEA
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECC
DWPLRLDLKPGSRVPAHCSASGKLLLALLPRDERNALLRAMPLPRHTPNTIADPALLEAE
CCCEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LDRIAHRGLAIDNEEFVPGIVCIAAPIVDAQGACVAAVAVHAPVSRAPLSRLLDSAPRVQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHH
EAARALAETF
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]