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The map label for this gene is 189352642

Identifier: 189352642

GI number: 189352642

Start: 729816

End: 730574

Strand: Direct

Name: 189352642

Synonym: BMULJ_03873

Alternate gene names: NA

Gene position: 729816-730574 (Clockwise)

Preceding gene: 189352641

Following gene: 189352643

Centisome position: 29.51

GC content: 69.7

Gene sequence:

>759_bases
ATGCAATTCACGCAAGCGATCGTTCGCCGCCCGGCGCCCACCTGTGGCGCGGGTCTCACCACGGCCGCGCTCGGCGCGCC
CGACTACGACAAGACGCTCGCGCAGTTCGACGCGTACTGCGACGTGCTGAGCGCGCTGGGCGTTGCGGTGACCGAGCTGC
CGCCGCTGCCCGCGTTTCCCGATGCCCATTTCGTCGAGGACGTCGCGGTCGTGACGCCCGAATTCGCGGTGATCACGCGC
CCCGGTGCGCCTGCGCGGCGCGGCGAGACCGTGCACATCGAGGCAGCGCTCGCCGCGCATCGCGATCTGCTGCCGATGCG
CGCCGGCCGCCTCGACGGCGGCGACGTGATGCTCGTCGGCAAGCGCTTCTATATCGGCCTGACGAGCCGCACCGACGCGG
AAGGCATCGCCGAGTTCGAGTCGCTGGTGTCGCGCTACGGTTATTCGGTCGTGGCGATGCCGGTGGCCGCGGGCCTGCAT
CTGAAGTCGGTCGTCAACGCGCTCGGCGACGACACGCTGCTCGTCACCGAAGCGCTCGCCGCGCATCCGGCCTTCGCCGG
GTATCGACGGATCGCGATCCGCGCCGAGGACGAATATGCAGGCAACACGCTGCGCGTGAACGGGACGCTGATCACGCCGG
CCGGCTATCCGCGCGTGCACGACGCGATCGCGCCGGTCGGCCTGCCGTTGCACGTGATCGACACGAGCGAATTCCGCAAG
ATGGACGGCGGCCTCACGTGTCTGTCGCTGCGGTTCTAG

Upstream 100 bases:

>100_bases
AAATCGACGCGAATTGCGCAATTTGGCTTCCGATAATGGTCCGACACAACGCAAGCCGTGCCGCGCGACGCGATGCGCGG
CGATGACCCTGGAGAAGCCG

Downstream 100 bases:

>100_bases
CCGATTGGCGCGCAGTCGCTTCGGCCGGATAATGTGGCCCGCGGAACCGGAGCACGCGTTCCGCGCACCAGCCACGACCC
GACCGGAGCGAATGCGGATG

Product: N-dimethylarginine dimethylaminohydrolase

Products: NA

Alternate protein names: DDAH; Dimethylarginine dimethylaminohydrolase; Dimethylargininase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQFTQAIVRRPAPTCGAGLTTAALGAPDYDKTLAQFDAYCDVLSALGVAVTELPPLPAFPDAHFVEDVAVVTPEFAVITR
PGAPARRGETVHIEAALAAHRDLLPMRAGRLDGGDVMLVGKRFYIGLTSRTDAEGIAEFESLVSRYGYSVVAMPVAAGLH
LKSVVNALGDDTLLVTEALAAHPAFAGYRRIAIRAEDEYAGNTLRVNGTLITPAGYPRVHDAIAPVGLPLHVIDTSEFRK
MDGGLTCLSLRF

Sequences:

>Translated_252_residues
MQFTQAIVRRPAPTCGAGLTTAALGAPDYDKTLAQFDAYCDVLSALGVAVTELPPLPAFPDAHFVEDVAVVTPEFAVITR
PGAPARRGETVHIEAALAAHRDLLPMRAGRLDGGDVMLVGKRFYIGLTSRTDAEGIAEFESLVSRYGYSVVAMPVAAGLH
LKSVVNALGDDTLLVTEALAAHPAFAGYRRIAIRAEDEYAGNTLRVNGTLITPAGYPRVHDAIAPVGLPLHVIDTSEFRK
MDGGLTCLSLRF
>Mature_252_residues
MQFTQAIVRRPAPTCGAGLTTAALGAPDYDKTLAQFDAYCDVLSALGVAVTELPPLPAFPDAHFVEDVAVVTPEFAVITR
PGAPARRGETVHIEAALAAHRDLLPMRAGRLDGGDVMLVGKRFYIGLTSRTDAEGIAEFESLVSRYGYSVVAMPVAAGLH
LKSVVNALGDDTLLVTEALAAHPAFAGYRRIAIRAEDEYAGNTLRVNGTLITPAGYPRVHDAIAPVGLPLHVIDTSEFRK
MDGGLTCLSLRF

Specific function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

Organism=Homo sapiens, GI6912328, Length=266, Percent_Identity=34.2105263157895, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI197313763, Length=157, Percent_Identity=32.484076433121, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7524354, Length=159, Percent_Identity=32.7044025157233, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI18859791, Length=268, Percent_Identity=30.2238805970149, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 26753; Mature: 26753

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFTQAIVRRPAPTCGAGLTTAALGAPDYDKTLAQFDAYCDVLSALGVAVTELPPLPAFP
CCHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DAHFVEDVAVVTPEFAVITRPGAPARRGETVHIEAALAAHRDLLPMRAGRLDGGDVMLVG
CCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHCCHHHCCCCCCCCEEEEE
KRFYIGLTSRTDAEGIAEFESLVSRYGYSVVAMPVAAGLHLKSVVNALGDDTLLVTEALA
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHCCCHHHHHHHHH
AHPAFAGYRRIAIRAEDEYAGNTLRVNGTLITPAGYPRVHDAIAPVGLPLHVIDTSEFRK
HCCCCCCEEEEEEEECCCCCCCEEEECCEEECCCCCCHHHHHHCCCCCEEEEECCHHHHH
MDGGLTCLSLRF
CCCCEEEEEEEC
>Mature Secondary Structure
MQFTQAIVRRPAPTCGAGLTTAALGAPDYDKTLAQFDAYCDVLSALGVAVTELPPLPAFP
CCHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DAHFVEDVAVVTPEFAVITRPGAPARRGETVHIEAALAAHRDLLPMRAGRLDGGDVMLVG
CCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHCCHHHCCCCCCCCEEEEE
KRFYIGLTSRTDAEGIAEFESLVSRYGYSVVAMPVAAGLHLKSVVNALGDDTLLVTEALA
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHCCCHHHHHHHHH
AHPAFAGYRRIAIRAEDEYAGNTLRVNGTLITPAGYPRVHDAIAPVGLPLHVIDTSEFRK
HCCCCCCEEEEEEEECCCCCCCEEEECCEEECCCCCCHHHHHHCCCCCEEEEECCHHHHH
MDGGLTCLSLRF
CCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 11473257 [H]