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The map label for this gene is emrA [H]

Identifier: 189352601

GI number: 189352601

Start: 682878

End: 683996

Strand: Reverse

Name: emrA [H]

Synonym: BMULJ_03832

Alternate gene names: 189352601

Gene position: 683996-682878 (Counterclockwise)

Preceding gene: 189352603

Following gene: 189352600

Centisome position: 27.66

GC content: 69.97

Gene sequence:

>1119_bases
ATGTCGACGCCGCAAGACCCGCCACAGAAAGCAGATCGTCAGGAAAACGGAACAACGCCGCGCAACGGCGTCTCGAAGCG
GCGCATCCTGCTCGCGATTGCCGTGCTCGCGGCAATCGGCGGCGCCGTCTGGTTCGGCCGCTGGTGGACCGTCGGCCGCT
TCATCGAAAGCACCAACGACGCCTATCTGCAGGCGGACAGCATGACCGCCGCACCGAAAGTCGCCGGCTACGTGACCGAC
GTGTACGTGCGCGACAACCAGCCGGTGAAGGCCGGCGATCCGCTCGTGCGGCTCGACGTCCGCCCGTACCGGGTCGCGCT
CGATCAGGCGAACGCGACCGTCGACGCACGCCGCGCCGACATTGCGCGCGCCCAGGCCGAGATCAGCCAGCAGCGCGCGA
ATCTCGAACAGGCGCAAGCGCAGGCGAAGGTCTCGCAGATCAACGCACGGCATGCGAGCGACGAATACGCGCGCTATGCG
CCGCTCGCGGCGACCGGTGCGGAAACGCACGAGCGCGTCGCCGAGCTGAAGAGCGCGCGCGACCAGGCGCTCGCGACGCT
CGCCGCGAACGATGCCGCGATCGCGGCCGCGCGCACGCAGATCGCATCGTTCGGCGCGCAGCTGCAGCAGGCGCGCGCGC
AGCTCGAGGCCGCGCAGGCGAGCGCCGCGCAGTCGCGGCTCGACCTCGACAACACGATCGTGCGCGCGACGCTCGACGGG
CGTGTCGGCGACCGCACGGTGCGCGTCGGCCAGTACGTGCAGCCCGGCACGCGGCTGCTCACGGTCGTGCCGGTCGATGC
GATCTATCTCGTCGCGAACTTCAAGGAAACGCAGATCGGCCGCATGCGTGTCGGCCAGCCGGTCGAACTGCATGTCGATG
CGCTGCCGGACGATACGCTGTCGGGCGTCGTCGACAGCTTCGCACCGGGCACCGGCGCGCAGTTCGCGCTGCTGCCGCCG
GAGAACGCGACCGGCAACTTCACGAAGATCGTGCAGCGCGTACCGGTGCGCATCCGCATCGCACCGAACGAGCGCGCGCG
GCACATGCTGCTGCCGGGGCTGTCGGTGACGGTCGACGTCGACACGCGCTCGGCGCGCAACGAGAACCGTCATGGCTGA

Upstream 100 bases:

>100_bases
TTCGCTCATGCCTTCCTCGTCACTCGATCGATCGACATTCTACTTGACACATTTTTATCAACTGGAATAATTCTTCCGCT
CGGAATAAATTGGATCCTAC

Downstream 100 bases:

>100_bases
GCCGACTGCCACCGTGCCGCCCGCGCCGCCGCATGAAGGCCGCGCGAGCGTGACCGACTGGATCGCCGTCGCGGCCGGCG
CGCTCGGCGCGTTGATGGCG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSTPQDPPQKADRQENGTTPRNGVSKRRILLAIAVLAAIGGAVWFGRWWTVGRFIESTNDAYLQADSMTAAPKVAGYVTD
VYVRDNQPVKAGDPLVRLDVRPYRVALDQANATVDARRADIARAQAEISQQRANLEQAQAQAKVSQINARHASDEYARYA
PLAATGAETHERVAELKSARDQALATLAANDAAIAAARTQIASFGAQLQQARAQLEAAQASAAQSRLDLDNTIVRATLDG
RVGDRTVRVGQYVQPGTRLLTVVPVDAIYLVANFKETQIGRMRVGQPVELHVDALPDDTLSGVVDSFAPGTGAQFALLPP
ENATGNFTKIVQRVPVRIRIAPNERARHMLLPGLSVTVDVDTRSARNENRHG

Sequences:

>Translated_372_residues
MSTPQDPPQKADRQENGTTPRNGVSKRRILLAIAVLAAIGGAVWFGRWWTVGRFIESTNDAYLQADSMTAAPKVAGYVTD
VYVRDNQPVKAGDPLVRLDVRPYRVALDQANATVDARRADIARAQAEISQQRANLEQAQAQAKVSQINARHASDEYARYA
PLAATGAETHERVAELKSARDQALATLAANDAAIAAARTQIASFGAQLQQARAQLEAAQASAAQSRLDLDNTIVRATLDG
RVGDRTVRVGQYVQPGTRLLTVVPVDAIYLVANFKETQIGRMRVGQPVELHVDALPDDTLSGVVDSFAPGTGAQFALLPP
ENATGNFTKIVQRVPVRIRIAPNERARHMLLPGLSVTVDVDTRSARNENRHG
>Mature_371_residues
STPQDPPQKADRQENGTTPRNGVSKRRILLAIAVLAAIGGAVWFGRWWTVGRFIESTNDAYLQADSMTAAPKVAGYVTDV
YVRDNQPVKAGDPLVRLDVRPYRVALDQANATVDARRADIARAQAEISQQRANLEQAQAQAKVSQINARHASDEYARYAP
LAATGAETHERVAELKSARDQALATLAANDAAIAAARTQIASFGAQLQQARAQLEAAQASAAQSRLDLDNTIVRATLDGR
VGDRTVRVGQYVQPGTRLLTVVPVDAIYLVANFKETQIGRMRVGQPVELHVDALPDDTLSGVVDSFAPGTGAQFALLPPE
NATGNFTKIVQRVPVRIRIAPNERARHMLLPGLSVTVDVDTRSARNENRHG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=337, Percent_Identity=34.1246290801187, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789041, Length=372, Percent_Identity=34.1397849462366, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1790519, Length=289, Percent_Identity=31.4878892733564, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081951, Length=317, Percent_Identity=24.6056782334385, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789637, Length=349, Percent_Identity=25.214899713467, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789900, Length=353, Percent_Identity=25.4957507082153, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790012, Length=254, Percent_Identity=29.1338582677165, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790024, Length=249, Percent_Identity=27.710843373494, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40203; Mature: 40071

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPQDPPQKADRQENGTTPRNGVSKRRILLAIAVLAAIGGAVWFGRWWTVGRFIESTND
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYLQADSMTAAPKVAGYVTDVYVRDNQPVKAGDPLVRLDVRPYRVALDQANATVDARRAD
CEEEECCCCCCCHHHCEEEEEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHH
IARAQAEISQQRANLEQAQAQAKVSQINARHASDEYARYAPLAATGAETHERVAELKSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHH
DQALATLAANDAAIAAARTQIASFGAQLQQARAQLEAAQASAAQSRLDLDNTIVRATLDG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
RVGDRTVRVGQYVQPGTRLLTVVPVDAIYLVANFKETQIGRMRVGQPVELHVDALPDDTL
CCCCCEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEECCCCEEEEEECCCCHHH
SGVVDSFAPGTGAQFALLPPENATGNFTKIVQRVPVRIRIAPNERARHMLLPGLSVTVDV
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCEEECCCCEEEEEE
DTRSARNENRHG
CCCCCCCCCCCC
>Mature Secondary Structure 
STPQDPPQKADRQENGTTPRNGVSKRRILLAIAVLAAIGGAVWFGRWWTVGRFIESTND
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYLQADSMTAAPKVAGYVTDVYVRDNQPVKAGDPLVRLDVRPYRVALDQANATVDARRAD
CEEEECCCCCCCHHHCEEEEEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHH
IARAQAEISQQRANLEQAQAQAKVSQINARHASDEYARYAPLAATGAETHERVAELKSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHH
DQALATLAANDAAIAAARTQIASFGAQLQQARAQLEAAQASAAQSRLDLDNTIVRATLDG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
RVGDRTVRVGQYVQPGTRLLTVVPVDAIYLVANFKETQIGRMRVGQPVELHVDALPDDTL
CCCCCEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCEECCCCEEEEEECCCCHHH
SGVVDSFAPGTGAQFALLPPENATGNFTKIVQRVPVRIRIAPNERARHMLLPGLSVTVDV
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCEEECCCCEEEEEE
DTRSARNENRHG
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]