Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 189352580

GI number: 189352580

Start: 654365

End: 655312

Strand: Direct

Name: serA [H]

Synonym: BMULJ_03811

Alternate gene names: 189352580

Gene position: 654365-655312 (Clockwise)

Preceding gene: 189352579

Following gene: 189352581

Centisome position: 26.46

GC content: 68.14

Gene sequence:

>948_bases
ATGCAGACCGCTTCGCACAAGCCCGTGGTCCTCGTGACCGCCGCCGACCTTGCACCGCAAGCGCTCGAGATGCTTGCGCA
GTTCGACGTCGTGTTCGCCGGCAAGCAGCCGACCGAAGACGACATCGTCGCGCTCTGCGTCAAGCACAAGCCGGTCGCGA
TCATCGTCCGGTACGGCAAGATCAACGCCCGCGTCATGGACGCGGCCGAAAATCTGCAGGTGATCTCGAAGCACGGCAGC
GGCATCGACGTGATCGATCAGGACGCTGCGGCCGCACGCGGCATCGCGGTGCGCGCCGCGGTCGGCGCGAATGCGGCCGC
CGTCGCCGAACACGCATGGGCGCTGATCCTCGCATGCGCGAAGTCGGTTCCGCAGCTCGATATGCGCATGCGCGAGGGCC
ATTGGGACAAGGCGACGCACAAGTCGGTCGAACTCGACGGGCGCACGCTTGGCCTCGTCGGACTCGGTGCGATCGGCCGG
CGCGTGGCCGCGATCGGCGTGGCGTTCGGCATGAAGGTGCTCGCGTTCGATCCGTTCGCAAAGGAAGCGCCCGCCGGAGT
GACGCTGGTGCCGCTCGACACGCTGTACGCGGAGTCGGATGTCGTCTCGATGCATTGCCCGCTGACGGCCGACAACCGCC
GGATGCTCAACCGCGACACGCTCGCGCGCTTCAAGCGCGGGGCGATTCTCGTCAACACGGCGCGTGGCGGTCTGATCGAC
GAAGCGGCGCTCGCCGAAGCGCTGACGAGCGGCCCGTTGCGTGCGGCCGCGCTCGACAGCTTCGACGTGGAGCCGATGAC
GTCGCCGCACCCGTTCCAGCAGCTCCCCAACGTGATCCTGTCTCCGCATATCGGCGGCGTGAGCGATGCCGCGTACGTGA
ACATGGGCAAGGGCGCGGCCGCCAACGTCCTCGCAGTGCTCGACGAACGCGCGCACAGCGCGGCCTGA

Upstream 100 bases:

>100_bases
CCGCGCGTATCGCGGCGATCCACAAGGGCGACGTCCGTCCGGGCTGGATCGAGAAGGAACTGCGCGCAGCCGGCATGCTG
GCCGAAGGCGAGGCGCTGTG

Downstream 100 bases:

>100_bases
ACCACAACATCGAGGTACGCATGTTTTATCTGACGAGCCCCGACGTGCGCGAAGCCGAAGTGTTCACGCGCATGCCGGAG
AAGTTTCGCAAGCCGGACGT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQTASHKPVVLVTAADLAPQALEMLAQFDVVFAGKQPTEDDIVALCVKHKPVAIIVRYGKINARVMDAAENLQVISKHGS
GIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACAKSVPQLDMRMREGHWDKATHKSVELDGRTLGLVGLGAIGR
RVAAIGVAFGMKVLAFDPFAKEAPAGVTLVPLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID
EAALAEALTSGPLRAAALDSFDVEPMTSPHPFQQLPNVILSPHIGGVSDAAYVNMGKGAAANVLAVLDERAHSAA

Sequences:

>Translated_315_residues
MQTASHKPVVLVTAADLAPQALEMLAQFDVVFAGKQPTEDDIVALCVKHKPVAIIVRYGKINARVMDAAENLQVISKHGS
GIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACAKSVPQLDMRMREGHWDKATHKSVELDGRTLGLVGLGAIGR
RVAAIGVAFGMKVLAFDPFAKEAPAGVTLVPLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID
EAALAEALTSGPLRAAALDSFDVEPMTSPHPFQQLPNVILSPHIGGVSDAAYVNMGKGAAANVLAVLDERAHSAA
>Mature_315_residues
MQTASHKPVVLVTAADLAPQALEMLAQFDVVFAGKQPTEDDIVALCVKHKPVAIIVRYGKINARVMDAAENLQVISKHGS
GIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACAKSVPQLDMRMREGHWDKATHKSVELDGRTLGLVGLGAIGR
RVAAIGVAFGMKVLAFDPFAKEAPAGVTLVPLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID
EAALAEALTSGPLRAAALDSFDVEPMTSPHPFQQLPNVILSPHIGGVSDAAYVNMGKGAAANVLAVLDERAHSAA

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=38.1526104417671, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=36.4, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=36.4, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=36.4, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=36.4, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=35.7976653696498, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=31.9066147859922, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=35.3413654618474, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787645, Length=203, Percent_Identity=34.9753694581281, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082289, Length=255, Percent_Identity=31.3725490196078, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788660, Length=241, Percent_Identity=28.6307053941909, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87081824, Length=235, Percent_Identity=23.8297872340426, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=34.5394736842105, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=296, Percent_Identity=29.7297297297297, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=263, Percent_Identity=31.1787072243346, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=297, Percent_Identity=29.96632996633, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=246, Percent_Identity=32.1138211382114, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=215, Percent_Identity=31.1627906976744, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=169, Percent_Identity=31.9526627218935, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=34.1216216216216, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=38.9344262295082, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=38.9344262295082, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=38.9344262295082, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=38.9344262295082, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI62472511, Length=247, Percent_Identity=39.2712550607287, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=28.0757097791798, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=26.4984227129338, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=315, Percent_Identity=30.4761904761905, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=29.6442687747036, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=29.6442687747036, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=29.6442687747036, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=29.6442687747036, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=29.6442687747036, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33019; Mature: 33019

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTASHKPVVLVTAADLAPQALEMLAQFDVVFAGKQPTEDDIVALCVKHKPVAIIVRYGK
CCCCCCCCEEEEEECCCCHHHHHHHHHHCEEEECCCCCCCCEEEEEECCCCEEEEEEECC
INARVMDAAENLQVISKHGSGIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACA
CCEEEECHHHHHHHHHCCCCCCCEECCCHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHH
KSVPQLDMRMREGHWDKATHKSVELDGRTLGLVGLGAIGRRVAAIGVAFGMKVLAFDPFA
HCCCHHHHHHHCCCCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCCH
KEAPAGVTLVPLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID
HCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCH
EAALAEALTSGPLRAAALDSFDVEPMTSPHPFQQLPNVILSPHIGGVSDAAYVNMGKGAA
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCHHHCCCCCCCCCCCCEEECCCCCH
ANVLAVLDERAHSAA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTASHKPVVLVTAADLAPQALEMLAQFDVVFAGKQPTEDDIVALCVKHKPVAIIVRYGK
CCCCCCCCEEEEEECCCCHHHHHHHHHHCEEEECCCCCCCCEEEEEECCCCEEEEEEECC
INARVMDAAENLQVISKHGSGIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACA
CCEEEECHHHHHHHHHCCCCCCCEECCCHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHH
KSVPQLDMRMREGHWDKATHKSVELDGRTLGLVGLGAIGRRVAAIGVAFGMKVLAFDPFA
HCCCHHHHHHHCCCCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCCH
KEAPAGVTLVPLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID
HCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCH
EAALAEALTSGPLRAAALDSFDVEPMTSPHPFQQLPNVILSPHIGGVSDAAYVNMGKGAA
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCHHHCCCCCCCCCCCCEEECCCCCH
ANVLAVLDERAHSAA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]