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The map label for this gene is dxs [H]

Identifier: 189352477

GI number: 189352477

Start: 526731

End: 528635

Strand: Direct

Name: dxs [H]

Synonym: BMULJ_03696

Alternate gene names: 189352477

Gene position: 526731-528635 (Clockwise)

Preceding gene: 189352476

Following gene: 189352478

Centisome position: 21.3

GC content: 66.56

Gene sequence:

>1905_bases
ATGTACGACTTGCTGAAAACCATCGACGACCCGGCGGACCTGCGCCGCCTCGATCGTCGCCAACTGCAACCGCTCGCGGA
TGAACTGCGTGCGTTCGTGCTCGACAGCGTGTCGAAGACGGGCGGCCATTTGTCGTCCAACCTCGGGACGGTCGAGCTGA
CGATCGCGCTGCACTACGTGTTCAACACGCCGAACGATCGCATCGTCTGGGACGTGGGGCACCAGACCTACCCGCACAAG
ATCCTGACCGGCCGCCGCGACGAAATGCCGACGCTGCGCCAGCTCGGCGGCATCTCGGGCTTCCCGCGCCGCTCCGAATC
CGAATACGACACCTTCGGCACCGCGCATTCGAGCACGTCGATCTCGGCCGCGCTCGGCATGGCGATCGGCAGCCAGCTCA
ACGGCGACGACCGTTTCTCGATCGCGGTGATCGGCGACGGCGCGATGACGGCCGGCATGGCGTTCGAGGCGATGAACAAC
GCCGGCGTGTCCGAGGACGCGAAACTGCTCGTGATCCTGAACGACAACGACATGTCGATTTCGCCGCCGGTCGGCGCGCT
GAACCGCCATCTCGCGCGTCTGATGTCGGGTCGCTTCTACGCGGCCGCGCGTGCGGGCGTCGAGCGCGTGCTGAGCGTCG
CGCCGCCCGTGCTCGAACTCGCGCGCAAGCTCGAGGAGCATGCGAAGGGCATGGTCGTGCCGGCCACGCTGTTCGAGGAA
TTCGGCTTCAACTACATCGGCCCGATCGACGGTCACGATCTCGATTCGCTGATCCCGACGCTGCAGAACATCCGCGAGCT
GCGCGGCCCGCAGTTCCTGCACGTCGTCACGAAGAAGGGGCAGGGCTACAAGCTCGCCGAAGCCGATCCGGTGCTCTATC
ACGGCCCCGGCAAGTTCAATCCGGCCGAAGGCATCAAACCGTCCGCGACGCCCGCGAAGAAGACGTACACGCAGGTGTTC
GGCGAGTGGCTGTGCGACGAGGCCGAGCGCGATTCGCGCGTCGTCGGCATCACGCCCGCGATGCGCGAAGGCTCGGGCAT
GGTCGAGTTCGAGAAGCGCTTCAAGGATCGCTACTACGACGTCGGCATCGCCGAACAGCACGCGGTGACGTTCGCCGGCG
GCCTCGCGACCGAAGGCCTGAAGCCCGTCGTCGCGATCTATTCGACGTTCCTGCAACGCGCGTACGACCAGCTGATCCAC
GACGTCGCGCTGCAGAACCTGCCGGTCGTGTTCGCGATCGACCGCGCGGGCCTCGTCGGCGCCGACGGTGCGACGCATGC
GGGCGCGTACGATCTCGCGTTCATGCGCTGCATTCCGAACATGACGATCATGGCGGCATCGGACGAGAACGAATGCCGTC
AGATGCTGCACACGGCGCTGCAACAGCCGAACCCGACCGCGGTGCGCTATCCGCGCGGCGCGGGCACCGGCGTCGCGACG
GTGAAGGAATTCACCGAGCTGCCGATCGGCAAGGGCGAGGTGCGCCGCCGCACGTCGCAGCCGGAAGGCAAGCGCATCGC
GATCCTCGCGTTCGGCACGATGGTCGCGCCGTCGCTCGCAGCGGCCGAAGAGCTCGATGCAACCGTCGCGAACATGCGTT
TCGTGAAGCCGCTCGACGCGGCGCTCGTGCGCGAGCTCGCGGAGACGCACGACTTCCTCGTCACCGCCGAAGAAGGCTGT
GTGATGGGCGGGGCAGGCTCGGCCTGCGTCGAAGCCCTGATGGAGAGTGGGGTTATCCGACCCGTACTACAATTGGGCCT
CCCTGACCAGTTCATCGATCACGGCGACCCCGCGAAGCTGCTGTCGCTCTGCGGCCTCGACGGCGTGGGCATCGCGAAAT
CGATTCGCGAACGCTTCCTGAACCCGGCAACCGGCGTTGCCGGTCAGGCAAAGCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
GTGAACCGGGTCAGCTGACGCGAAAGCCCGCCGCCGCGCACACGCTACGGGTGCGTGCAACAGAATGCGGGCGCGTTTGA
TTTCCTACAATGGAACGACG

Downstream 100 bases:

>100_bases
GCCGGCGCCGCCTGAGGGCGGCATCGGCGCGACTGGCGCAACCGGTCTTCATTGATGCGGAAAAACATGGGCCTGCGGGC
CCATGTTGCTTTTCCGGCTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHK
ILTGRRDEMPTLRQLGGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSATPAKKTYTQVF
GEWLCDEAERDSRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKEFTELPIGKGEVRRRTSQPEGKRIAILAFGTMVAPSLAAAEELDATVANMRFVKPLDAALVRELAETHDFLVTAEEGC
VMGGAGSACVEALMESGVIRPVLQLGLPDQFIDHGDPAKLLSLCGLDGVGIAKSIRERFLNPATGVAGQAKRVA

Sequences:

>Translated_634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHK
ILTGRRDEMPTLRQLGGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSATPAKKTYTQVF
GEWLCDEAERDSRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKEFTELPIGKGEVRRRTSQPEGKRIAILAFGTMVAPSLAAAEELDATVANMRFVKPLDAALVRELAETHDFLVTAEEGC
VMGGAGSACVEALMESGVIRPVLQLGLPDQFIDHGDPAKLLSLCGLDGVGIAKSIRERFLNPATGVAGQAKRVA
>Mature_634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHK
ILTGRRDEMPTLRQLGGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSATPAKKTYTQVF
GEWLCDEAERDSRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKEFTELPIGKGEVRRRTSQPEGKRIAILAFGTMVAPSLAAAEELDATVANMRFVKPLDAALVRELAETHDFLVTAEEGC
VMGGAGSACVEALMESGVIRPVLQLGLPDQFIDHGDPAKLLSLCGLDGVGIAKSIRERFLNPATGVAGQAKRVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=638, Percent_Identity=23.6677115987461, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI4507521, Length=638, Percent_Identity=23.6677115987461, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI225637463, Length=302, Percent_Identity=26.8211920529801, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637459, Length=302, Percent_Identity=26.8211920529801, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI225637461, Length=302, Percent_Identity=26.8211920529801, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI156564403, Length=280, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1786622, Length=617, Percent_Identity=57.8606158833063, Blast_Score=743, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538422, Length=298, Percent_Identity=24.8322147651007, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=310, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666278, Length=645, Percent_Identity=24.4961240310078, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551847, Length=668, Percent_Identity=23.8023952095808, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45550715, Length=668, Percent_Identity=23.8023952095808, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24645119, Length=556, Percent_Identity=24.2805755395683, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358145, Length=277, Percent_Identity=29.9638989169675, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650940, Length=277, Percent_Identity=29.9638989169675, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68449; Mature: 68449

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPNDRIVWDVGHQTYPHKILTGRRDEMPTLRQLGGISGFPRRSESEYDTFGTAHSSTS
EECCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHCCCCCCCCH
ISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSI
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHHH
FGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFN
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCEEEECCCCCC
PAEGIKPSATPAKKTYTQVFGEWLCDEAERDSRVVGITPAMREGSGMVEFEKRFKDRYYD
CCCCCCCCCCCHHHHHHHHHHHHHHCHHCCCCEEEECCCCHHCCCCCHHHHHHHHHHHCC
VGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVG
CCCCCHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHH
VKEFTELPIGKGEVRRRTSQPEGKRIAILAFGTMVAPSLAAAEELDATVANMRFVKPLDA
HHHHHHCCCCCHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ALVRELAETHDFLVTAEEGCVMGGAGSACVEALMESGVIRPVLQLGLPDQFIDHGDPAKL
HHHHHHHHHHCEEEECCCCEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCHHHH
LSLCGLDGVGIAKSIRERFLNPATGVAGQAKRVA
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCC
>Mature Secondary Structure
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPNDRIVWDVGHQTYPHKILTGRRDEMPTLRQLGGISGFPRRSESEYDTFGTAHSSTS
EECCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHCCCCCCCCH
ISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSI
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHHH
FGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFN
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCEEEECCCCCC
PAEGIKPSATPAKKTYTQVFGEWLCDEAERDSRVVGITPAMREGSGMVEFEKRFKDRYYD
CCCCCCCCCCCHHHHHHHHHHHHHHCHHCCCCEEEECCCCHHCCCCCHHHHHHHHHHHCC
VGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVG
CCCCCHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHH
VKEFTELPIGKGEVRRRTSQPEGKRIAILAFGTMVAPSLAAAEELDATVANMRFVKPLDA
HHHHHHCCCCCHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ALVRELAETHDFLVTAEEGCVMGGAGSACVEALMESGVIRPVLQLGLPDQFIDHGDPAKL
HHHHHHHHHHCEEEECCCCEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCHHHH
LSLCGLDGVGIAKSIRERFLNPATGVAGQAKRVA
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA