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The map label for this gene is shlA [H]

Identifier: 189352166

GI number: 189352166

Start: 195419

End: 197584

Strand: Reverse

Name: shlA [H]

Synonym: BMULJ_03384

Alternate gene names: 189352166

Gene position: 197584-195419 (Counterclockwise)

Preceding gene: 189352167

Following gene: 189352162

Centisome position: 7.99

GC content: 67.68

Gene sequence:

>2166_bases
ATGCAACACACTCGTCAACCCCATCTCCCTCCCGCGCAGCCATGCGCGCGTCGCGCGCTCGTCGCGGCACTCGCGTGCGC
GATGCCGCTGTTCGCCGCGCATGCGCAGAATGCGCCGCTCGTCGTCGATCCGTCGGCCGCCCATCGTCCGACGCTCGCGA
ATGGCGCGAACGGCACGCCGATCGTCAATATCGCGGCGCCCGACGGCGCGGGCCTCTCGCACAACCGCTTCACCGAGTAC
AACGTGGGTGCCGCGGGCCTCGTGCTGAACAACAGCGCACACGCGGTCGACACGCAGCTCGCAGGCCGCATCGACGGCAA
TACGCTGCTCGGCGGCAGGCCCGCGTCGGTGATCCTCAACCAGGTGACGGGCGGCAACGCGTCGATGCTGGCCGGCGCGA
CGGAAGTCGCCGGGCACGCCGCGCGCGTGATCGTCGCGAATCCGAACGGAATCGGCGTGAACGGCGGCAGCTTCATCAAC
GCGAATCACGTGTCGCTCGTCGCCGGTACCGTCGAATTCGACGAGCAGGGTGCGATCCGACAGTTCCGCACCGAGCACGG
CCGCATCGCGATCGACGGCGCGGGGCTCGATGCGCGCGACGTCGACCAGCTCGATCTCGTGTCGCGCACGCTGCAGGTCA
ATGCCGCGCTGCACGCGCGCCGCGTGACGACCGTCGCGCAGCGCGGTACCGCGAACGTCGAACAGCCGGGCAGTCATCAG
TTGTCGGGGCAAGGCGACGGCGCGATGCCCGACGTCGCGATCGACGTGTCGAAGCTCGGCAGCATGCACGCGTCGGCGAT
CACGATGCACGGTTCGTCGGCCGGTGTCGGCGTGAATCTCGCGGGCAAGGTCGATGCGGTCACCGGCGGCATCGCGATTT
CGTCGGGCGGGATCGTGAAGGTGCAGGACGGCGGCAGCCTGACGGCCGACCGTCTGTCGATCAACGGCAACCTCGACAAC
GCGGGCAGCGTGCGTGCAGGCCGCGCGCTGAGCGCGATGGGGACGCTGCACAACCGCGCTGGCGGCCGGATCGAAAGCGG
CGGCACGCTGTCGTCGATGGGCAGCGTGCGCAATGCAGGCACGCTGCATGCGGACGCTGCGATGTCGCTGATGGGTGCGC
TCAAGAACGAGCGCGGCGCGCGCATCAGCAGCTACGGACGGATCAATCAGATGGGACACGTGAGCAATGCGGGAGAACTC
GTACAGTTCGCGCCGCGGCCGACGGTGGCGCCGGTGGAGGATAAGCCGGCGTCGACGGCGCCGGCGGGTGTTGCGGGGAA
CGACGTGGGTGGGTCGGAGGGGGCGACGGCGGTTGTGGAGAAGCCTGTCGCACCGACCGCGCCGGTCATCGCGGAGAGCA
AGCCGGGTCTGCCTGAAGTCTCGACGCCTGTCACGGAAAAGCCCGTTGCGCCGACCGCACCGGTCATCGCGGAAAGCAAG
CCGGGTCTGCCTGAAGTCTCGACGCCGGCTACGGAAAAGCCTGTCGCACCGACCGCACCGGTCGTCGCAGAAAACAAACC
GACTCAACCCGACGTTCCTACGCCGGTTACGGAGAAGCCCGTCGCACCGACCGCGCCGGTCATCGCGGAAAACAAACCGA
CTCAGCCGAACGTTCCGACACCGATCATCGAGGAGCCTGTCCCACCGACCGCGCCGATCATCGCAGAAAGCAAACCGACT
CAGCCCGACGTTCAAACGCCGGTTACGGAGAAGCCCGTCACGCCGACGGCGCCGGTTATCGCGGAAAACAAACCGACTCA
GCCGAACGTTCCAACGCCGATCACCGAGAAGCCTGTCCCACCGACGGCACCGGTTATCGCAGAAAGCAAGCCGACTCAGC
CCGACGTTCCTACGCCGGTCACGGAGAAGCCCGTCGCACCGACCGCGCCGATCATCGCGGAAAACAAACCGCCTCAGCCC
GCACGGCCGACCGCACCGATCGCCGCCAAACCGTTCCCGCCGACGATCGCGGCCTTTGCGCCGATCTTCATTCCGTCGAT
CACGATTCCGTCGATCACGATCGCGCCGATTCGTCCGATCGGTTTCCCGACGTTTGCGTTTTCGCCGATCGCGCCGCCCG
CGCTGCCGACATTCGGCATGATCCCGCGACCGACGATGTTCGCGCCGATGCCGGCGTTCTCGCTCACGTTGGCATCGCGC
GTCTGA

Upstream 100 bases:

>100_bases
CATGTAAATCGTTCGCCCGTCACGGCCGCGCCGCAGCGCGGCCCGTTCCGGCGCGGCCTGCGCCGTGCCGTCGTTTTGAA
CCTTCATCATCGGGATGATC

Downstream 100 bases:

>100_bases
TCACGCGCATTCGATAGTCGGCCACCGCCGACGACGGTTGTCGACGAACGCGCCGCGCGCGACGCATGCGTCTTATCGCA
CACGCGTCGCGCGCGCTTCA

Product: large exoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MQHTRQPHLPPAQPCARRALVAALACAMPLFAAHAQNAPLVVDPSAAHRPTLANGANGTPIVNIAAPDGAGLSHNRFTEY
NVGAAGLVLNNSAHAVDTQLAGRIDGNTLLGGRPASVILNQVTGGNASMLAGATEVAGHAARVIVANPNGIGVNGGSFIN
ANHVSLVAGTVEFDEQGAIRQFRTEHGRIAIDGAGLDARDVDQLDLVSRTLQVNAALHARRVTTVAQRGTANVEQPGSHQ
LSGQGDGAMPDVAIDVSKLGSMHASAITMHGSSAGVGVNLAGKVDAVTGGIAISSGGIVKVQDGGSLTADRLSINGNLDN
AGSVRAGRALSAMGTLHNRAGGRIESGGTLSSMGSVRNAGTLHADAAMSLMGALKNERGARISSYGRINQMGHVSNAGEL
VQFAPRPTVAPVEDKPASTAPAGVAGNDVGGSEGATAVVEKPVAPTAPVIAESKPGLPEVSTPVTEKPVAPTAPVIAESK
PGLPEVSTPATEKPVAPTAPVVAENKPTQPDVPTPVTEKPVAPTAPVIAENKPTQPNVPTPIIEEPVPPTAPIIAESKPT
QPDVQTPVTEKPVTPTAPVIAENKPTQPNVPTPITEKPVPPTAPVIAESKPTQPDVPTPVTEKPVAPTAPIIAENKPPQP
ARPTAPIAAKPFPPTIAAFAPIFIPSITIPSITIAPIRPIGFPTFAFSPIAPPALPTFGMIPRPTMFAPMPAFSLTLASR
V

Sequences:

>Translated_721_residues
MQHTRQPHLPPAQPCARRALVAALACAMPLFAAHAQNAPLVVDPSAAHRPTLANGANGTPIVNIAAPDGAGLSHNRFTEY
NVGAAGLVLNNSAHAVDTQLAGRIDGNTLLGGRPASVILNQVTGGNASMLAGATEVAGHAARVIVANPNGIGVNGGSFIN
ANHVSLVAGTVEFDEQGAIRQFRTEHGRIAIDGAGLDARDVDQLDLVSRTLQVNAALHARRVTTVAQRGTANVEQPGSHQ
LSGQGDGAMPDVAIDVSKLGSMHASAITMHGSSAGVGVNLAGKVDAVTGGIAISSGGIVKVQDGGSLTADRLSINGNLDN
AGSVRAGRALSAMGTLHNRAGGRIESGGTLSSMGSVRNAGTLHADAAMSLMGALKNERGARISSYGRINQMGHVSNAGEL
VQFAPRPTVAPVEDKPASTAPAGVAGNDVGGSEGATAVVEKPVAPTAPVIAESKPGLPEVSTPVTEKPVAPTAPVIAESK
PGLPEVSTPATEKPVAPTAPVVAENKPTQPDVPTPVTEKPVAPTAPVIAENKPTQPNVPTPIIEEPVPPTAPIIAESKPT
QPDVQTPVTEKPVTPTAPVIAENKPTQPNVPTPITEKPVPPTAPVIAESKPTQPDVPTPVTEKPVAPTAPIIAENKPPQP
ARPTAPIAAKPFPPTIAAFAPIFIPSITIPSITIAPIRPIGFPTFAFSPIAPPALPTFGMIPRPTMFAPMPAFSLTLASR
V
>Mature_721_residues
MQHTRQPHLPPAQPCARRALVAALACAMPLFAAHAQNAPLVVDPSAAHRPTLANGANGTPIVNIAAPDGAGLSHNRFTEY
NVGAAGLVLNNSAHAVDTQLAGRIDGNTLLGGRPASVILNQVTGGNASMLAGATEVAGHAARVIVANPNGIGVNGGSFIN
ANHVSLVAGTVEFDEQGAIRQFRTEHGRIAIDGAGLDARDVDQLDLVSRTLQVNAALHARRVTTVAQRGTANVEQPGSHQ
LSGQGDGAMPDVAIDVSKLGSMHASAITMHGSSAGVGVNLAGKVDAVTGGIAISSGGIVKVQDGGSLTADRLSINGNLDN
AGSVRAGRALSAMGTLHNRAGGRIESGGTLSSMGSVRNAGTLHADAAMSLMGALKNERGARISSYGRINQMGHVSNAGEL
VQFAPRPTVAPVEDKPASTAPAGVAGNDVGGSEGATAVVEKPVAPTAPVIAESKPGLPEVSTPVTEKPVAPTAPVIAESK
PGLPEVSTPATEKPVAPTAPVVAENKPTQPDVPTPVTEKPVAPTAPVIAENKPTQPNVPTPIIEEPVPPTAPIIAESKPT
QPDVQTPVTEKPVTPTAPVIAENKPTQPNVPTPITEKPVPPTAPVIAESKPTQPDVPTPVTEKPVAPTAPIIAENKPPQP
ARPTAPIAAKPFPPTIAAFAPIFIPSITIPSITIAPIRPIGFPTFAFSPIAPPALPTFGMIPRPTMFAPMPAFSLTLASR
V

Specific function: Cell-bound hemolysin, which releases heme-iron from erythrocytes by interaction with the erythrocyte membrane. ShlA requires shlB function [H]

COG id: COG3210

COG function: function code U; Large exoproteins involved in heme utilization or adhesion

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI16554449, Length=344, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010069
- InterPro:   IPR008638
- InterPro:   IPR012334
- InterPro:   IPR011050
- InterPro:   IPR011102 [H]

Pfam domain/function: PF05860 Haemagg_act [H]

EC number: NA

Molecular weight: Translated: 73106; Mature: 73106

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHTRQPHLPPAQPCARRALVAALACAMPLFAAHAQNAPLVVDPSAAHRPTLANGANGTP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCE
IVNIAAPDGAGLSHNRFTEYNVGAAGLVLNNSAHAVDTQLAGRIDGNTLLGGRPASVILN
EEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHCCCCCCEEECCCCHHHHEE
QVTGGNASMLAGATEVAGHAARVIVANPNGIGVNGGSFINANHVSLVAGTVEFDEQGAIR
CCCCCCHHEECCHHHHCCCEEEEEEECCCCCCCCCCCEECCCCEEEEEEEEEECCCCHHH
QFRTEHGRIAIDGAGLDARDVDQLDLVSRTLQVNAALHARRVTTVAQRGTANVEQPGSHQ
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LSGQGDGAMPDVAIDVSKLGSMHASAITMHGSSAGVGVNLAGKVDAVTGGIAISSGGIVK
CCCCCCCCCCCEEEEHHHHCCCCEEEEEECCCCCCCCEEECCCEEEEECCEEECCCCEEE
VQDGGSLTADRLSINGNLDNAGSVRAGRALSAMGTLHNRAGGRIESGGTLSSMGSVRNAG
ECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHCCCCCCC
TLHADAAMSLMGALKNERGARISSYGRINQMGHVSNAGELVQFAPRPTVAPVEDKPASTA
CCHHHHHHHHHHHHHCCCCCEEHHCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
PAGVAGNDVGGSEGATAVVEKPVAPTAPVIAESKPGLPEVSTPVTEKPVAPTAPVIAESK
CCCCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCC
PGLPEVSTPATEKPVAPTAPVVAENKPTQPDVPTPVTEKPVAPTAPVIAENKPTQPNVPT
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PIIEEPVPPTAPIIAESKPTQPDVQTPVTEKPVTPTAPVIAENKPTQPNVPTPITEKPVP
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
PTAPVIAESKPTQPDVPTPVTEKPVAPTAPIIAENKPPQPARPTAPIAAKPFPPTIAAFA
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
PIFIPSITIPSITIAPIRPIGFPTFAFSPIAPPALPTFGMIPRPTMFAPMPAFSLTLASR
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
V
C
>Mature Secondary Structure
MQHTRQPHLPPAQPCARRALVAALACAMPLFAAHAQNAPLVVDPSAAHRPTLANGANGTP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCE
IVNIAAPDGAGLSHNRFTEYNVGAAGLVLNNSAHAVDTQLAGRIDGNTLLGGRPASVILN
EEEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHCCCCCCEEECCCCHHHHEE
QVTGGNASMLAGATEVAGHAARVIVANPNGIGVNGGSFINANHVSLVAGTVEFDEQGAIR
CCCCCCHHEECCHHHHCCCEEEEEEECCCCCCCCCCCEECCCCEEEEEEEEEECCCCHHH
QFRTEHGRIAIDGAGLDARDVDQLDLVSRTLQVNAALHARRVTTVAQRGTANVEQPGSHQ
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LSGQGDGAMPDVAIDVSKLGSMHASAITMHGSSAGVGVNLAGKVDAVTGGIAISSGGIVK
CCCCCCCCCCCEEEEHHHHCCCCEEEEEECCCCCCCCEEECCCEEEEECCEEECCCCEEE
VQDGGSLTADRLSINGNLDNAGSVRAGRALSAMGTLHNRAGGRIESGGTLSSMGSVRNAG
ECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHCCCCCCC
TLHADAAMSLMGALKNERGARISSYGRINQMGHVSNAGELVQFAPRPTVAPVEDKPASTA
CCHHHHHHHHHHHHHCCCCCEEHHCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
PAGVAGNDVGGSEGATAVVEKPVAPTAPVIAESKPGLPEVSTPVTEKPVAPTAPVIAESK
CCCCCCCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCC
PGLPEVSTPATEKPVAPTAPVVAENKPTQPDVPTPVTEKPVAPTAPVIAENKPTQPNVPT
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PIIEEPVPPTAPIIAESKPTQPDVQTPVTEKPVTPTAPVIAENKPTQPNVPTPITEKPVP
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
PTAPVIAESKPTQPDVPTPVTEKPVAPTAPIIAENKPPQPARPTAPIAAKPFPPTIAAFA
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
PIFIPSITIPSITIAPIRPIGFPTFAFSPIAPPALPTFGMIPRPTMFAPMPAFSLTLASR
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]