| Definition | Burkholderia multivorans ATCC 17616 chromosome 2, complete genome. |
|---|---|
| Accession | NC_010805 |
| Length | 2,473,162 |
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The map label for this gene is fabG [H]
Identifier: 189352069
GI number: 189352069
Start: 88380
End: 89219
Strand: Direct
Name: fabG [H]
Synonym: BMULJ_03286
Alternate gene names: 189352069
Gene position: 88380-89219 (Clockwise)
Preceding gene: 189352068
Following gene: 189352073
Centisome position: 3.57
GC content: 71.07
Gene sequence:
>840_bases ATGGACACGCCCCACCCGCCGACGCACACCGCGATCCCGGAAACCGAATTCGAAGCCGAGGTCGACGCCGAAGTCGAAAC CGCCGTCGAGCCGCGCGCGTCGCGCGTGCATCGGCCCGTCGCGCTCGTCACGGGATCGACGTCGGGGATCGGCGCGGCGA TTGCACGGCGCCTCGCCGCGGACGGTTACGCGGTGATCCTGCATTCGCTGCGGTCCGTCGAGACGGGCCGCGCGATGGCG ACCGAACTCGGCGGGGCATACGTGCAGGCCGATCTCGCCGACGATGCCGAACGCGTGCGGCTGATCCGCGATGCGCTCGC GGTGCACGGCCGCCTCGACGTGCTCGTCAACAACGCGGGCATCAGCCGCACGATCGCGCACGACGATCTGGCGGCCGCGA CGCCCGACGTATGGCGCGAGCTGTACGAGATCAACGCGATCGCGCCGTTTCGGCTCGTCGCCGAAGCGCAGCCCGCGCTG CTCGAAGCGGCGTCGCACGGGCGTGCCGGCTGCGTCGTGAACGTCAGTTCGCACGCCGGTGTGCGGCCGAAGGGCGCATC GATTCCGTATGCGGCCGCGAAAGCGGCGCTCAATCACACGACGCGCCTGCTCGCGCGCACGCTGGCGCCGGCCATCCGCA TCAATGCGGTCGCGCCGGGCCTCGTCGATACGCCGCTGACGGCCGACTGGACCGACGCGCAGCAGCTCTGGCGCGAGCGT GCGCCGATGCGCCGCGCGGCGACGCCGGACGACGTCGCGCAGACGGTCGCGATGCTCGTCGCGTCCGACTACGTGACGGG CGAGATCATCATGCTCGACGGCGGATTGAATCTGACGTAG
Upstream 100 bases:
>100_bases CACGATGTGCGACGCGCGCGCTGCCGCGATCGCGCGCGAGATTCGCGCGGCGGCGCGCGTCGCGCTTATGATGCGGAATC GCCATCCGCAGGGTTCCGCC
Downstream 100 bases:
>100_bases CGGGGCGTCGCGGGCTGCCGGTCCGCTGATCGGGGTCGTCGCGCTGTGTGCTGCGGCCAGGATCGGGGGCTGCGTCTCGC TACGGTCGATGAGCCCCCAC
Product: 3-oxoacyl-[acyl-carrier protein] reductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: ORF6 [H]
Number of amino acids: Translated: 279; Mature: 279
Protein sequence:
>279_residues MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT
Sequences:
>Translated_279_residues MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT >Mature_279_residues MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=37.5, Blast_Score=125, Evalue=5e-29, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=35.2226720647773, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=33.0645161290323, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=32.1428571428571, Blast_Score=96, Evalue=5e-20, Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=36.9230769230769, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=32.3308270676692, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=37.8378378378378, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI59889578, Length=213, Percent_Identity=29.5774647887324, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=9e-15, Organism=Homo sapiens, GI31542939, Length=202, Percent_Identity=29.2079207920792, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI83715985, Length=249, Percent_Identity=28.5140562248996, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=30.0492610837438, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=28.6307053941909, Blast_Score=65, Evalue=8e-11, Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=28.780487804878, Blast_Score=65, Evalue=1e-10, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=34.6774193548387, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=33.8709677419355, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=31.3953488372093, Blast_Score=88, Evalue=8e-19, Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=32.5, Blast_Score=87, Evalue=2e-18, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=33.59375, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=31.496062992126, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=29.4820717131474, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=28.8617886178862, Blast_Score=78, Evalue=6e-16, Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=29.2, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=27.0491803278689, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=30, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1787820, Length=226, Percent_Identity=27.4336283185841, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1787526, Length=211, Percent_Identity=28.436018957346, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=35.8870967741936, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=34.0659340659341, Blast_Score=111, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=31.3953488372093, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=31.0606060606061, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=30.8300395256917, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=30.3703703703704, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=32.319391634981, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=28.6764705882353, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=31.9702602230483, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=32.1033210332103, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=30.6201550387597, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=30.3370786516854, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=31.3653136531365, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.1526717557252, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.0196078431373, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.4878048780488, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=29.7397769516729, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17538486, Length=272, Percent_Identity=31.6176470588235, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.4776119402985, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=29.8892988929889, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=31.3653136531365, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=28.9156626506024, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=27.6752767527675, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17568967, Length=284, Percent_Identity=22.887323943662, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=7e-16, Organism=Saccharomyces cerevisiae, GI6322226, Length=193, Percent_Identity=32.6424870466321, Blast_Score=76, Evalue=6e-15, Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=31.3492063492063, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=34.8837209302326, Blast_Score=109, Evalue=2e-24, Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=32.9457364341085, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=30.7086614173228, Blast_Score=94, Evalue=8e-20, Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=31.6205533596838, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=31.4516129032258, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=32.520325203252, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=30.1587301587302, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24640442, Length=198, Percent_Identity=32.8282828282828, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI24644337, Length=179, Percent_Identity=34.0782122905028, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI116007236, Length=208, Percent_Identity=28.3653846153846, Blast_Score=65, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 29483; Mature: 29483
Theoretical pI: Translated: 5.56; Mature: 5.56
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAA CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHC DGYAVILHSLRSVETGRAMATELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAG CCHHHHHHHHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC ISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPALLEAASHGRAGCVVNVSSHAG CCCHHCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCC VRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHH APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC >Mature Secondary Structure MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAA CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHC DGYAVILHSLRSVETGRAMATELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAG CCHHHHHHHHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC ISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPALLEAASHGRAGCVVNVSSHAG CCCHHCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCC VRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHH APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2583128; 9831526 [H]