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The map label for this gene is gutB [H]

Identifier: 189352000

GI number: 189352000

Start: 19946

End: 21067

Strand: Reverse

Name: gutB [H]

Synonym: BMULJ_03217

Alternate gene names: 189352000

Gene position: 21067-19946 (Counterclockwise)

Preceding gene: 189352001

Following gene: 189351999

Centisome position: 0.85

GC content: 70.59

Gene sequence:

>1122_bases
ATGCGCGCACTTCAATGGCATGGCCCGCGCGACGTCCGTCTCGTCGACATCGACACGCCGCGCGTCGGGCCGGGCGAGGT
ACGCATCGCCGTCGCGTATTGCGGCATCTGCGGCAGCGATCTGCACGAATACGCGGACGGCCCGCACGCGATTCCGGTCG
ACGCACCGCATCCGCTGTCCGGGCGCACCGCACCGCTGACGCTCGGTCACGAGTTCTGCGGCACCGTCGTCGAAGTCGGC
GCGGGCGTGACGACGTTGCGCGCCGGCGACCGTGTCGCGGTCGAGCCCGAGTATCGCTGCCAGCGCTGCGCGTACTGCCG
GGCCGGCTCGTACAACCTCTGCGTATCGATGGGCTTTGCCGGGCTCATGGGCGACGGCGGAATGGCCGACTTCGCGGTCG
TGCCGGCCTATATGCTGCATCGCCTGCCCGAGGGCGTCACGCTCGAACAGGCGGCAGTGCTCGAGCCCGCCGCCGTCGCG
CTGCATGCACTGCGGCGCGGCGAGCTGCGGCTCGGCAATACCTGCGCGGTGTTCGGCCTCGGACCGATCGGACTGCTGCT
GATCATGCTCGCGAAGCTGCAAGGGGCGACCACGATCGTCGCCGTCGACGTGTCGCCGCAGCGCCTCGCGGCCGCGAAGC
GCTTCGGCGCGACGCGCGCGTTCGACGCCCGCTCGCTCGATGCGGCCGCGCTGCGCGACGCGATTCGCGCGGAAACCGGC
GGCCTCGGCGTCGACGTCGCGTTCGAGGCGGCCGGGCTGCCCGCGACGTTCGAAGCCGCGATGCACGCCTTGCGCAAAGG
CGGACGCGTCGTGATGGTCGGCCTGATGCCGCACGCGGGCTTCGATGCGTTTCGCGCCGTCAACGACGAGCTGACCTTCA
CGGCGAGCGTCGGCTACCGGCACGCGTACGACGATCTGCTGCGCATCGTCGCGTCCGGCGTACTCGATCCGGCGTCGATC
GTCACGCGCACCGTCGCGCTTGAGCACGCGATCGCCGACGGCTTCGACGCGCTGCTCGCCGACCGCACGCAGATCAAGGT
TCTCGTTTCACCGGCGCTCGGCGCGAGCCGCCGCACCTATGCCTCGGGGAGCATCGAACATGAGCCAAGCGCAGACGTTT
GA

Upstream 100 bases:

>100_bases
ATCGGCCTCGTCGAAACTGCGCCCGCGGTATTGCGCAGGCGCGCGCTCGCGAGCGCCGCCGCGCGCCGTTTCGATACGCA
AAACCTCGGAGGACGCTGAC

Downstream 100 bases:

>100_bases
GCGCAAGACCGTCGTCGTGACGGGCGGTACATCGGGAATCGGCGCACATACCGCACTGCGTTTCGCAAAAGCGGGCGCGT
CGGTCGTCAGCATCGGGCTG

Product: L-iditol 2-dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRALQWHGPRDVRLVDIDTPRVGPGEVRIAVAYCGICGSDLHEYADGPHAIPVDAPHPLSGRTAPLTLGHEFCGTVVEVG
AGVTTLRAGDRVAVEPEYRCQRCAYCRAGSYNLCVSMGFAGLMGDGGMADFAVVPAYMLHRLPEGVTLEQAAVLEPAAVA
LHALRRGELRLGNTCAVFGLGPIGLLLIMLAKLQGATTIVAVDVSPQRLAAAKRFGATRAFDARSLDAAALRDAIRAETG
GLGVDVAFEAAGLPATFEAAMHALRKGGRVVMVGLMPHAGFDAFRAVNDELTFTASVGYRHAYDDLLRIVASGVLDPASI
VTRTVALEHAIADGFDALLADRTQIKVLVSPALGASRRTYASGSIEHEPSADV

Sequences:

>Translated_373_residues
MRALQWHGPRDVRLVDIDTPRVGPGEVRIAVAYCGICGSDLHEYADGPHAIPVDAPHPLSGRTAPLTLGHEFCGTVVEVG
AGVTTLRAGDRVAVEPEYRCQRCAYCRAGSYNLCVSMGFAGLMGDGGMADFAVVPAYMLHRLPEGVTLEQAAVLEPAAVA
LHALRRGELRLGNTCAVFGLGPIGLLLIMLAKLQGATTIVAVDVSPQRLAAAKRFGATRAFDARSLDAAALRDAIRAETG
GLGVDVAFEAAGLPATFEAAMHALRKGGRVVMVGLMPHAGFDAFRAVNDELTFTASVGYRHAYDDLLRIVASGVLDPASI
VTRTVALEHAIADGFDALLADRTQIKVLVSPALGASRRTYASGSIEHEPSADV
>Mature_373_residues
MRALQWHGPRDVRLVDIDTPRVGPGEVRIAVAYCGICGSDLHEYADGPHAIPVDAPHPLSGRTAPLTLGHEFCGTVVEVG
AGVTTLRAGDRVAVEPEYRCQRCAYCRAGSYNLCVSMGFAGLMGDGGMADFAVVPAYMLHRLPEGVTLEQAAVLEPAAVA
LHALRRGELRLGNTCAVFGLGPIGLLLIMLAKLQGATTIVAVDVSPQRLAAAKRFGATRAFDARSLDAAALRDAIRAETG
GLGVDVAFEAAGLPATFEAAMHALRKGGRVVMVGLMPHAGFDAFRAVNDELTFTASVGYRHAYDDLLRIVASGVLDPASI
VTRTVALEHAIADGFDALLADRTQIKVLVSPALGASRRTYASGSIEHEPSADV

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=33.9339339339339, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4501929, Length=384, Percent_Identity=28.125, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI71565154, Length=296, Percent_Identity=30.0675675675676, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4501933, Length=382, Percent_Identity=27.7486910994764, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI34577061, Length=379, Percent_Identity=25.8575197889182, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI71565152, Length=385, Percent_Identity=24.1558441558442, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=384, Percent_Identity=25, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71743840, Length=384, Percent_Identity=25, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4501939, Length=303, Percent_Identity=27.0627062706271, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI156523966, Length=303, Percent_Identity=27.0627062706271, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22538446, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI22538444, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788073, Length=316, Percent_Identity=33.2278481012658, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=28.2485875706215, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=29.1907514450867, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788407, Length=267, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=29.4444444444444, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=31.0344827586207, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI226510992, Length=279, Percent_Identity=32.9749103942652, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786825, Length=408, Percent_Identity=29.656862745098, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87081918, Length=297, Percent_Identity=34.006734006734, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87082125, Length=271, Percent_Identity=34.6863468634686, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=27.3458445040214, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787572, Length=227, Percent_Identity=27.3127753303965, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786518, Length=288, Percent_Identity=28.4722222222222, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=329, Percent_Identity=32.8267477203647, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=328, Percent_Identity=31.7073170731707, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI25146526, Length=290, Percent_Identity=30.3448275862069, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=301, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=232, Percent_Identity=31.4655172413793, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=27.3015873015873, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=315, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=321, Percent_Identity=29.595015576324, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=377, Percent_Identity=32.6259946949602, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319258, Length=378, Percent_Identity=32.2751322751323, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319955, Length=323, Percent_Identity=34.984520123839, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322619, Length=323, Percent_Identity=34.6749226006192, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=32.1428571428571, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320033, Length=296, Percent_Identity=27.7027027027027, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=28.7066246056782, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=27.4447949526814, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=309, Percent_Identity=26.8608414239482, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=325, Percent_Identity=27.3846153846154, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=319, Percent_Identity=35.1097178683386, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17737897, Length=319, Percent_Identity=34.7962382445141, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17737895, Length=298, Percent_Identity=28.5234899328859, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI221457811, Length=333, Percent_Identity=25.2252252252252, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45550770, Length=333, Percent_Identity=25.2252252252252, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45551930, Length=333, Percent_Identity=25.2252252252252, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 39170; Mature: 39170

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALQWHGPRDVRLVDIDTPRVGPGEVRIAVAYCGICGSDLHEYADGPHAIPVDAPHPLS
CCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCC
GRTAPLTLGHEFCGTVVEVGAGVTTLRAGDRVAVEPEYRCQRCAYCRAGSYNLCVSMGFA
CCCCEEEECHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCCEEEECCCH
GLMGDGGMADFAVVPAYMLHRLPEGVTLEQAAVLEPAAVALHALRRGELRLGNTCAVFGL
HCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCCEEECCEEEEEEC
GPIGLLLIMLAKLQGATTIVAVDVSPQRLAAAKRFGATRAFDARSLDAAALRDAIRAETG
CHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
GLGVDVAFEAAGLPATFEAAMHALRKGGRVVMVGLMPHAGFDAFRAVNDELTFTASVGYR
CCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCEEEEEECCCH
HAYDDLLRIVASGVLDPASIVTRTVALEHAIADGFDALLADRTQIKVLVSPALGASRRTY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCCCEE
ASGSIEHEPSADV
CCCCCCCCCCCCC
>Mature Secondary Structure
MRALQWHGPRDVRLVDIDTPRVGPGEVRIAVAYCGICGSDLHEYADGPHAIPVDAPHPLS
CCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCC
GRTAPLTLGHEFCGTVVEVGAGVTTLRAGDRVAVEPEYRCQRCAYCRAGSYNLCVSMGFA
CCCCEEEECHHHHHHHHHHCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCCEEEECCCH
GLMGDGGMADFAVVPAYMLHRLPEGVTLEQAAVLEPAAVALHALRRGELRLGNTCAVFGL
HCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCCEEECCEEEEEEC
GPIGLLLIMLAKLQGATTIVAVDVSPQRLAAAKRFGATRAFDARSLDAAALRDAIRAETG
CHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
GLGVDVAFEAAGLPATFEAAMHALRKGGRVVMVGLMPHAGFDAFRAVNDELTFTASVGYR
CCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCEEEEEECCCH
HAYDDLLRIVASGVLDPASIVTRTVALEHAIADGFDALLADRTQIKVLVSPALGASRRTY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCCCEE
ASGSIEHEPSADV
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]